Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms DOI Creative Commons
Qian Li, Xizheng Wu, Shengdong Mu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(20)

Published: May 2, 2023

Engineering advanced therapeutic and diagnostic nano-bio-platforms (NBPFs) have emerged as rapidly-developed pathways against a wide range of challenges in antitumor, antipathogen, tissue regeneration, bioimaging, biosensing applications. Emerged 2D materials attracted extensive scientific interest fundamental building blocks or nanostructures among material scientists, chemists, biologists, doctors due to their advantageous physicochemical biological properties. This timely review provides comprehensive summary creating NBPFs via emerging (2D-NBPFs) with unique insights into the corresponding molecularly restructured microenvironments biofunctionalities. First, it is focused on an up-to-date overview synthetic strategies for designing 2D-NBPFs cross-comparison advantages disadvantages. After that, recent key achievements are summarized tuning biofunctionalities programmed microenvironments, including physiological stability, biocompatibility, bio-adhesiveness, specific binding pathogens, broad-spectrum pathogen inhibitors, stimuli-responsive systems, enzyme-mimetics. Moreover, representative applications also discussed detailed disclosure critical design principles parameters. Finally, current future research directions discussed. Overall, this will provide cutting-edge multidisciplinary guidance accelerating developments therapeutic/diagnostic 2D-NBPFs.

Language: Английский

Synergistic Interaction between Metal Single‐Atoms and Defective WO3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy DOI Creative Commons
Zhan Zhou, Tao Wang, Tingting Hu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Language: Английский

Citations

44
Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy DOI Creative Commons
Jiankang Zhang, Yu Yang,

Fengmin Qin

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Language: Английский

Citations

43
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications DOI
Hui Huang,

Yi Zheng,

Meiqi Chang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

Citations

32
A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains DOI
Wen Qin, Qiaoling Yang, Chunyan Zhu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

Citations

28
Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications DOI Creative Commons
Lei Li, Irem Soyhan, Eliza M. Warszawik

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 19, 2024

Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.

Language: Английский

Citations

27
Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy DOI Creative Commons

Xumeng Wu,

Ziqi Zhou, Kai Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

Citations

26
Lysosomal Rupture‐Mediated “Broken Window Effect” to Amplify Cuproptosis and Pyroptosis for High‐Efficiency Cancer Immunotherapy DOI
Guo‐Qing Zhu,

Man Wang,

Luying Qiao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 23, 2024

Abstract Autophagy, a lysosome‐involved degradation pathway, as self‐protective cellular process, always weakens the efficiency of tumor therapies. Herein, for first time, biodegradable copper (Cu) ions doped layered double hydroxide (Cu‐LDH) nanoparticles are reported cancer immunotherapy via lysosomal rupture‐mediated “Broken Window Effect”. Only injection Cu‐LDH single therapeutic agent achieves various organelles destruction after rupture, well abnormal aggregation Cu in cells cuproptosis and pyroptosis. More importantly, autophagy inhibition caused by rupture improves overload‐mediated pyroptosis blocking lysosome‐mediated bulk leading to good anti‐tumor immune responses ultimately high‐efficiency growth inhibition. This Effect” provides new paradigm enhanced therapy.

Language: Английский

Citations

23
Oxygen‐Vacancy‐Engineered W18O49−x Nanobrush with a Suitable Band Structure for Highly Efficient Sonodynamic Therapy DOI
Pan Zheng,

Yijiati Ami'erjiang,

Bin Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(9)

Published: Jan. 12, 2024

With the rapid development of external minimally invasive or noninvasive therapeutic modalities, ultrasound-based sonodynamic therapy (SDT) is a new alternative for treating deep tumors. However, inadequate sonosensitizer efficiency and poor biosecurity limit clinical applications. In this study, we prepared an oxygen-vacancy-engineered W

Language: Английский

Citations

20
2D MOFs nanosheets derived from 2D LDHs as a multifunctional sensitizer for sono-photodynamic therapy-mediated tumor treatment DOI
Tingting Hu, Tao Wang, Yu-Sheng Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159771 - 159771

Published: Jan. 1, 2025

Language: Английский

Citations

2
Defect Engineering in Biomedical Sciences DOI Open Access
Meng Yuan, Mehraneh Kermanian, Tarun Agarwal

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: June 4, 2023

Abstract With the promotion of nanochemistry research, large numbers nanomaterials have been applied in vivo to produce desirable cytotoxic substances response endogenous or exogenous stimuli for achieving disease‐specific therapy. However, performance is a critical issue that difficult improve and optimize under biological conditions. Defect‐engineered nanoparticles become most researched hot materials biomedical applications recently due their excellent physicochemical properties, such as optical properties redox reaction capabilities. Importantly, can be easily adjusted by regulating type concentration defects without requiring other complex designs. Therefore, this tutorial review focuses on defect engineering briefly discusses classification, introduction strategies, characterization techniques. Several representative defective are especially discussed order reveal relationship between properties. A series disease treatment strategies based engineered summarized. By summarizing design application nanomaterials, simple but effective methodology provided researchers therapeutic effects nanomaterial‐based platforms from science perspective.

Language: Английский

Citations

39