Machine Learning‐Assisted Property Prediction of Solid‐State Electrolyte

Advanced Energy Materials, Journal Year: 2024, Volume and Issue: 14(20)

Published: Feb. 14, 2024

Abstract Machine learning (ML) exhibits substantial potential for predicting the properties of solid‐state electrolytes (SSEs). By integrating experimental or/and simulation data within ML frameworks, discovery and development advanced SSEs can be accelerated, ultimately facilitating their application in high‐end energy storage systems. This review commences with an introduction to background SSEs, including explicit definition, comprehensive classification, intrinsic physical/chemical properties, underlying mechanisms governing conductivity, challenges, future developments. An in‐depth explanation methodology is also elucidated. Subsequently, key factors that influence performance are summarized, thermal expansion, modulus, diffusivity, ionic reaction energy, migration barrier, band gap, activation energy. Finally, it offered perspectives on design prerequisites upcoming generations focusing real‐time property prediction, multi‐property optimization, multiscale modeling, transfer learning, automation high‐throughput experimentation, synergistic optimization full battery, all which crucial accelerating progress SSEs. aims guide novel SSE materials practical realization efficient reliable technologies.

Language: Английский

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Synergistic Interaction between Metal Single‐Atoms and Defective WO_3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Language: Английский

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Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO_2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Language: Английский

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CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007

Published: April 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Language: Английский

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Encapsulation engineering of porous crystalline frameworks for delayed luminescence and circularly polarized luminescence

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(13), P. 6694 - 6734

Published: Jan. 1, 2024

Delayed luminescence (DF), including phosphorescence and thermally activated delayed fluorescence (TADF), circularly polarized (CPL) exhibit common broad application prospects in optoelectronic displays, biological imaging, encryption. Thus, the combination of is attracting increasing attention. The encapsulation guest emitters various host matrices to form host-guest systems has been demonstrated be an appealing strategy further enhance and/or modulate their luminescence. Compared with conventional liquid crystals, polymers, supramolecular matrices, porous crystalline frameworks (PCFs) metal-organic (MOFs), covalent-organic (COFs), zeolites hydrogen-bonded organic (HOFs) can not only overcome shortcomings such as flexibility disorder but also achieve ordered guests long-term stability chiral structures, providing new promising platforms for development DF CPL. In this review, we provide a comprehensive critical summary recent progress photochemistry

Language: Английский

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Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

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Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

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Recent advances in metal-based nanomaterials for malignant bone tumor therapy

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117427 - 117427

Published: Feb. 20, 2025

Language: Английский

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AIE donor-dependent photosensitizer for enhance photodynamic antibacterial interface

Surfaces and Interfaces, Journal Year: 2023, Volume and Issue: 39, P. 102996 - 102996

Published: May 27, 2023

Language: Английский

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Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 14, 2024

Abstract This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D‐material integrated hydrogels, with a focus on their performance bone‐related applications. Various synthesis methods types 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, MXene are discussed, along strategies for incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical high surface area, strong near‐infrared (NIR) photon absorption controlled release capabilities, making them suitable range regeneration therapeutic In cancer therapy, 2D‐material‐based show promise photothermal photodynamic therapies, drug delivery (chemotherapy). The properties these materials enable selective tumor ablation upon NIR irradiation, while drug‐loading capacity facilitates targeted chemotherapeutic agents. Additionally, 2D‐materials ‐infused potent antibacterial activity, effective against multidrug‐resistant infections disruption biofilm generated implant surface. Moreover, synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, immunotherapy to enhance outcomes. bio‐imaging, serve versatile contrast agents imaging probes, enabling real‐time monitoring during imaging. Furthermore, bone regeneration, most incorporated promote osteogenesis tissue offering potential solutions defects repair. Overall, integration presents promising platform developing multifunctional theragenerative biomaterials.

Language: Английский

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