Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

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Nanomaterial based PVA nanocomposite hydrogels for biomedical sensing: Advances toward designing the ideal flexible/wearable nanoprobes

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 305, P. 102705 - 102705

Published: May 18, 2022

Language: Английский

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Intelligent biosensing strategies for rapid detection in food safety: A review

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 202, P. 114003 - 114003

Published: Jan. 17, 2022

Language: Английский

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MXene-based aptasensors: Advances, challenges, and prospects

Progress in Materials Science, Journal Year: 2022, Volume and Issue: 129, P. 100967 - 100967

Published: May 21, 2022

Language: Английский

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Aptasensors versus immunosensors—Which will prevail?

Engineering in Life Sciences, Journal Year: 2022, Volume and Issue: 22(3-4), P. 319 - 333

Published: Jan. 13, 2022

Since the invention of first biosensors 70 years ago, they have turned into valuable and versatile tools for various applications, ranging from disease diagnosis to environmental monitoring. Traditionally, antibodies been employed as capture probes in most biosensors, owing their innate ability bind target with high affinity specificity, are still considered gold standard. Yet, resulting immunosensors often suffer considerable limitations, which mainly ascribed antibody size, conjugation chemistry, stability, costs. Over past decade, aptamers emerged promising alternative presenting some advantages over existing constraints immunosensors, well new biosensing concepts. Herein, we review employment platforms, addressing main aspects biosensor design mechanism. We also aim compare both probe classes theoretical experimental perspectives. highlight that such comparisons not straightforward, these two families should be necessarily perceived competing but rather complementary. We, thus, elaborate on combined use hybrid schemes benefiting each biorecognition element.

Language: Английский

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Aptamer–Protein Interactions: From Regulation to Biomolecular Detection

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(22), P. 12471 - 12506

Published: Nov. 6, 2023

Serving as the basis of cell life, interactions between nucleic acids and proteins play essential roles in fundamental cellular processes. Aptamers are unique single-stranded oligonucleotides generated by vitro evolution methods, possessing ability to interact with specifically. Altering structure aptamers will largely modulate their further affect related behaviors. Recently, in-depth research aptamer–protein interactions, analytical assays based on have been widely developed become a powerful tool for biomolecular detection. There some insightful reviews applied protein detection, while few systematic discussions from perspective regulating interactions. Herein, we comprehensively introduce methods elaborate detection techniques analyzing Additionally, this review provides broad summary regulation detecting biomolecules. Finally, present our perspectives regarding opportunities challenges biological analysis, aiming provide guidance disease mechanism drug discovery.

Language: Английский

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Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 187 - 187

Published: Jan. 15, 2024

In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize

Language: Английский

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Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2427 - 2443

Published: Feb. 1, 2025

The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity affinity target biomolecules, have emerged as promising tools precise diagnostics targeted therapies. Their selective binding capabilities provide valuable insights into molecular mechanisms underlying conditions. When integrated nanosystems, aptamers enhance delivery, bioavailability, stability agents, addressing challenges solubility degradation. This integration enables more drug advanced imaging techniques, improved interventions, ultimately improving management diseases. Recent advancements in aptamer selection methodologies, coupled their unique three-dimensional structures, significantly expanded application potential health. By combining novel approaches to disease diagnosis treatment are emerging, enhanced efficacy, safety, precision. review explores recent progress development aptamer-based nanosystems

Language: Английский

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Advances in Biomimetic Nanoparticles for Targeted Cancer Therapy and Diagnosis

Molecules, Journal Year: 2021, Volume and Issue: 26(16), P. 5052 - 5052

Published: Aug. 20, 2021

Biomimetic nanoparticles have recently emerged as a novel drug delivery platform to improve biocompatibility and specificity at the desired disease site, especially tumour microenvironment. Conventional often encounter rapid clearance by immune system poor drug-targeting effects. The development of nanotechnology provides an opportunity integrate different types biomaterials onto surface nanoparticles, which enables them mimic natural biological features functions cells. This mimicry strategy favours escape biomimetic from reduces potential toxic side Despite in this field, not much has progressed clinical stage. Thus, there is urgent need develop biomimetic-based nanomedicine produce highly specific effective system, for malignant tumours, can be used purposes. Here, recent developments various are discussed, along with their applications cancer imaging treatments.

Language: Английский

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Surface Engineering of Nanomaterials with Polymers, Biomolecules, and Small Ligands for Nanomedicine

Materials, Journal Year: 2022, Volume and Issue: 15(9), P. 3251 - 3251

Published: April 30, 2022

Nanomedicine is a speedily growing area of medical research that focused on developing nanomaterials for the prevention, diagnosis, and treatment diseases. Nanomaterials with unique physicochemical properties have recently attracted lot attention since they offer potential in biomedical research. Novel generations engineered nanostructures, also known as designed functionalized nanomaterials, opened up new possibilities applications approaches such biological imaging, biomolecular sensing, devices, drug delivery, therapy. Polymers, natural biomolecules, or synthetic ligands can interact physically chemically to functionalize them targeted uses. This paper reviews current nanotechnology, focus nanomaterial functionalization applications. Firstly, brief overview different types strategies their surface offered. Secondly, are reviewed. Then, cytotoxicity cost-effectiveness discussed. Finally, use diverse fields examined detail, including cancer treatment, tissue engineering, drug/gene implants.

Language: Английский

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