Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(10)
Published: Dec. 12, 2023
Metal-based
drugs
currently
dominate
the
field
of
chemotherapeutic
agents;
however,
achieving
controlled
activation
metal
prodrugs
remains
a
substantial
challenge.
Here,
we
propose
universal
strategy
for
radiation-triggered
via
nanosurface
energy
transfer
(NSET).
The
core-shell
nanoplatform
(Ru-GNC)
is
composed
gold
nanoclusters
(GNC)
and
ruthenium
(Ru)-containing
organic-inorganic
hybrid
coatings.
Upon
X-ray
irradiation,
Ru
(II)
complexes
were
released
in
manner
through
unique
NSET
process
involving
photoelectron
from
radiation-excited
Ru-GNCs
to
Ru-containing
layer.
In
contrast
traditional
prodrugs,
such
an
NSET-based
system
ensures
that
reactive
species
tumor
microenvironment
are
present
sufficient
quantity
not
easily
quenched.
Additionally,
ultrasmall
preferably
target
mitochondria
profoundly
disrupt
respiratory
chain
upon
leading
radiosensitization
by
generating
abundant
oxygen
species.
Consequently,
Ru-GNC-directed
radiochemotherapy
induces
immunogenic
cell
death,
resulting
significant
therapeutic
outcomes
when
combined
with
programmed
death-ligand
1
(PD-L1)
checkpoint
blockade.
This
represents
breakthrough
designing
nanoplatforms
metal-prodrug-mediated
cancer
treatment
efficient
controllable
manner.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(11), P. 7262 - 7378
Published: May 2, 2024
Ligand-protected
metal
clusters
possess
hybrid
properties
that
seamlessly
combine
an
inorganic
core
with
organic
ligand
shell,
imparting
them
exceptional
chemical
flexibility
and
unlocking
remarkable
application
potential
in
diverse
fields.
Leveraging
to
expand
the
library
of
available
materials
stimulate
development
new
functionalities
is
becoming
increasingly
pressing
requirement.
This
Review
focuses
on
origin
from
structural
analysis,
including
intra-cluster
bonding,
inter-cluster
interactions,
cluster-environments
metal-to-ligand
ratios,
thermodynamic
effects.
In
introduction,
we
briefly
outline
explain
differences
commonalities
M(I)/M(I/0)
coinage
clusters.
Additionally,
distinguish
bonding
characteristics
atoms
core,
which
give
rise
their
distinct
flexibility.
Section
2
delves
into
categories,
theories
related
following
sections
3
7,
primarily
elucidate
mechanisms
trigger
flexibility,
dynamic
processes
transformation,
resultant
alterations
structure,
ensuing
modifications
physical–chemical
properties.
8
presents
notable
applications
have
emerged
utilizing
assemblies.
Finally,
section
9,
discuss
future
challenges
opportunities
within
this
area.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(31)
Published: June 10, 2022
Abstract
Alloying
is
an
efficient
chemistry
to
tailor
the
properties
of
metal
clusters.
As
a
class
promising
radiosensitizers,
most
previously
reported
clusters
exhibit
unitary
function
and
cannot
overcome
radioresistance
hypoxic
tumors.
Here,
atomically
precise
alloy
Pt
2
M
4
(M
=
Au,
Ag,
Cu)
are
synthesized
with
bright
luminescence
adequate
biocompatibility,
their
composition‐dependent
enzyme
mimicking
activity
radiosensitizing
effect
explored.
Specifically,
only
Au
cluster
displays
catalase‐like
activity,
while
others
do
not
have
clusterzyme
properties,
its
highest
among
all
tested.
By
taking
advantage
sustainable
production
O
via
decomposition
endogenous
H
,
modulates
tumor
hypoxia
as
well
increases
efficacy
radiotherapy.
This
work
thus
advances
alloying
strategy
produce
multifunctional
therapeutic
agents
for
improving
therapy.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(14), P. 12021 - 12029
Published: March 30, 2022
Radiotherapy
is
one
of
the
most
widely
used
clinical
treatments
for
tumors,
but
it
faces
limitations,
such
as
poor
X-ray
retention
at
tumor
site.
The
use
radiosensitizers
containing
high
Z
elements
an
effective
way
to
enhance
absorption.
Here,
we
demonstrate
a
simple
one-step
method
synthesis
UiO-66-NH2(Hf)
metal-organic
framework
nanoparticles
in
radiotherapy.
had
diameter
less
than
100
nm
and
were
stable
physiological
environment.
induced
apoptosis
by
enhancing
absorption,
confirmed
vitro
vivo
experiments.
These
characteristics
make
promising
radiosensitizer
esophageal
cancer
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(51)
Published: Oct. 17, 2022
Fabricating
chiral
inorganic
materials
and
revealing
their
unique
quantum
confinement‐determined
optical
responses
are
crucial
tasks
in
the
multidisciplinary
fields
of
chemistry,
physics,
biology.
The
field
mesostructured
started
from
synthesis
individual
nanocrystals
evolved
to
include
assembly
metals,
semiconductors,
ceramics,
salts
endowed
with
various
structures
ranging
atomic
micron
scales.
This
tutorial
review
highlights
recent
research
on
materials,
especially
novel
expression
chirality
response,
it
may
inspire
us
new
strategies
for
design
opportunities
beyond
traditional
applications
chirality.
Fabrication
methods
classified
according
type,
scale,
symmetry‐breaking
mechanism.
Special
attention
is
given
highlight
systems
original
discoveries,
exceptional
phenomena,
or
mechanisms
response
left‐
right‐handedness.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(17)
Published: Feb. 13, 2023
Abstract
Glucocorticoid
(GC)‐induced
osteoporosis
(GIO)
is
a
concurrent
disease
commonly
appeared
in
chronic
inflammatory
and
autoimmune
patients.
Stereoselective
recognition
between
chiral
drugs
homochiral
biological
molecules
could
directly
affect
their
distribution,
adhesion
transport.
Herein,
trace
element
selenium
(Se)
with
bone
formation‐regulating
activity,
employed
to
construct
cysteine‐decorated
nanoparticles
(Cys@SeNPs)
attenuate
GIO.
Interestingly,
comparing
the
racemic
(DL‐Cys@SeNPs)
D‐Cys@SeNPs,
L‐Cys@SeNPs
displays
higher
uptake
osteoblast
cells
lessen
reactive
oxygen
species
overproduction
block
dexamethasone
(Dex)‐induced
osteoblasts
apoptosis.
Intracellular
be
predominantly
transformed
selenocystine
upregulate
expression
levels
of
antioxidative
selenoproteins
effectively
scavenge
Dex‐induced
excessive
ROS
accumulation
osteoblasts,
thus
reduce
undesirable
apoptosis
through
activating
Wnt/β‐catenin
pathway.
Consistently,
significantly
alleviates
main
symptoms
trabeculae
destruction
decreased
density
vivo,
also
reduces
weight
gain
fatty
liver
formation
Dex‐exposed
mice,
suppressing
overall
side
effects
Dex.
This
study
not
only
demonstrates
an
effective
strategy
for
treatment
GIO
by
using
Se
nanomedicine,
but
elucidates
important
roles
alleviating
osteoporosis,
which
help
future
Se‐based
drug
design
chirality
control
engineering.
Aggregate,
Journal Year:
2021,
Volume and Issue:
3(1)
Published: Dec. 8, 2021
Abstract
Recently,
materials
with
circularly
polarized
luminescence
(CPL)
properties
have
attracted
substantial
attention
because
they
offer
new
perspectives
in
fundamental
research
and
wide
applications
photonics,
bio‐encoding,
catalysis,
so
forth.
Such
importance
has
recently
promoted
the
development
of
CPL‐active
from
traditional
realm
organics
to
newly
released
areas
inorganics.
Due
advantages
inorganic
nanomaterials
stability,
high
luminescent
quantum
efficiency,
material
diversity,
diversity
shapes
sizes,
extensive
about
CPL
active
been
done
past
decades
leading
great
signs
progress
on
synthesis,
characterizations,
potential
applications.
In
this
review,
therefore,
we
will
thoroughly
describe
general
design
principles
activity,
basically
according
origins
chirality
nanomaterials:
intrinsic
nanomaterials,
ligand‐induced
chirality,
structural
caused
by
supramolecular
assembly,
respectively.
The
representative
are
presented
respect
challenges,
prospective,
problems
that
unsolved
date.
ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
13(42), P. 49581 - 49588
Published: Oct. 12, 2021
Quantum-sized
gold
nanoclusters
(AuNCs)
are
emerging
as
theranostic
agents-those
that
combine
diagnostics
and
therapeutic
properties-given
their
ultrasmall
size
<3
nm,
which
makes
them
behave
more
like
a
molecule
rather
than
nanoparticle.
This
molecule-like
behavior
endows
AuNCs
with
interesting
properties
including
photoluminescence,
catalytic
activity,
paramagnetism-all
without
the
presence
of
any
toxic
heavy
metal.
But
despite
these
fundamental
advances,
scalable
synthetic
approaches
to
produce
high-quality
well-controlled
programmable
for
biological
applications
well
methods
determine
structure-property
relationships
not
widely
available.
In
this
Perspective,
we
will
discuss
what
is
known
so
far
about
how
move
forward
propel
agent
choice
many
biomedical
applications.
