NIR‐Triggered Multifunctional NO Nanoplatform for Conquering Thermal Resistance in Biofilms

Small, Journal Year: 2024, Volume and Issue: 20(31)

Published: March 6, 2024

Abstract Photothermal treatment (PTT) has emerged as a promising avenue for biofilm elimination, yet its potential drawbacks, such local hyperpyrexia and bacterial heat resistance, have posed challenges. To address these concerns, an innovative nanoplatform (Au@mSiO 2 ‐arg/ICG) is devised that integrates phototherapeutic gas therapeutic functionalities. This multifaceted composed of mesoporous silica‐coated Au nanorods ), supplemented with l ‐arginine ( ‐arg) indocyanine green (ICG), engineered mild temperature PTT aimed at eradication. Au@mSiO ‐arg/ICG nanoparticles (NPs) show excellent antibacterial effects through the generation nitric oxide (NO) gas, heat, reactive oxygen species (ROS) under 808 nm light irradiation. The ROS generated by ICG initiates cascade reaction ‐arg, ultimately yielding NO molecules. localized release not only effectively curbs expression shock proteins 70 mitigating thermoresistance, but also reduces extracellular polymeric substance allowing better penetration agents. Furthermore, this achieves outstanding elimination rate over 99% in abscess model irradiation (0.8 W·cm −2 thereby establishing dependable strategy NO‐enhanced photodynamic therapy (aPDT) clinical settings.

Language: Английский

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Breaking Iron Homeostasis: Iron Capturing Nanocomposites for Combating Bacterial Biofilm

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Feb. 7, 2024

Given the scarcity of novel antibiotics, eradication bacterial biofilm infections poses formidable challenges. Upon infection, host restricts Fe ions, which are crucial for growth and maintenance. Having coevolved with host, bacteria developed adaptive pathways like hemin-uptake system to avoid iron deficiency. Inspired by this, we propose a strategy, termed nutritional immunity therapy (INIT), utilizing Ga-CT@P nanocomposites constructed gallium, copper-doped tetrakis (4-carboxyphenyl) porphyrin (TCPP) metal-organic framework, polyamine-amine polymer dots, target intakes starve them. Owing similarity between iron/hemin gallium/TCPP, gallium-incorporated potentially deceives into uptaking gallium ions concurrently extracts from surrounding milieu through ring. This strategy orchestrates "give take" approach Ga

Language: Английский

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Gold core@CeO2 halfshell Janus nanocomposites catalyze targeted sulfate radical for periodontitis therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 600 - 613

Published: May 14, 2024

Language: Английский

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Synergistic Effects of NO/H2S Gases on Antibacterial, Anti-inflammatory, and Analgesic Properties in Oral Ulcers Using a Gas-Releasing Nanoplatform

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Smart dental materials for antimicrobial applications

Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 1 - 19

Published: Dec. 9, 2022

Smart biomaterials can sense and react to physiological or external environmental stimuli (e.g., mechanical, chemical, electrical, magnetic signals). The last decades have seen exponential growth in the use development of smart dental for antimicrobial applications dentistry. These biomaterial systems offer improved efficacy controllable bio-functionalities prevent infections extend longevity devices. This review article presents current state-of-the-art design, evaluation, advantages, limitations bioactive stimuli-responsive autonomous materials applications. First, importance classification are discussed. Second, categories bioresponsive antibacterial systematically itemized based on different stimuli, including pH, enzymes, light, field, vibrations. For each category, their mechanism, applications, examples Finally, we examined obstacles required develop clinically relevant these appealing technologies.

Language: Английский

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Progress and prospects of nanomaterials against resistant bacteria

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 301 - 323

Published: Sept. 23, 2022

Language: Английский

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Recent advances on nanomaterials for antibacterial treatment of oral diseases

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100635 - 100635

Published: April 15, 2023

An imbalance of bacteria in oral environment can lead to a variety diseases, such as periodontal disease, dental caries, and peri-implant inflammation. In the long term, view increasing bacterial resistance, finding suitable alternatives traditional antibacterial methods is an important research today. With development nanotechnology, agents based on nanomaterials have attracted much attention field due their low cost, stable structures, excellent properties broad spectrum. Multifunctional break through limitations single therapy functions remineralization osteogenesis basis antibacterial, which has made significant progress long-term prevention treatment diseases. this review, we summarized applications metal oxides, organic composite recent five years. These not only inactivate bacteria, but also achieve more efficient diseases by improving materials themselves, enhancing precision targeted delivery drugs imparting richer functions. Finally, future challenges untapped potential are elaborated demonstrate prospects field.

Language: Английский

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Target-Driven Z-Scheme Heterojunction Formation for ppb H₂S Detection from Exhaled Breath at Room Temperature

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(7), P. 2824 - 2833

Published: June 22, 2023

As a biomarker of periodontitis, sensitive and timely monitoring hydrogen sulfide (H2S) in exhaled breath at room temperature (RT) is important for the early intervention oral diseases. However, required high operation to achieve sensitivity still technical challenge directly breath. In this study, by integrating metal-organic frameworks (MOFs) into self-aligned TiO2 nanotube arrays (NTs), chemiresistor gas sensor with outstanding selectivity was constructed detection H2S RT. The precise regulation Co(III)-based MOF CoBDC-NH2 (BDC-NH2 = 2-aminoterephthalic acid) not only induced more active surface preconcentration target but also caused buildup Z-scheme heterojunctions atmosphere that an ultrahigh RT via 365 nm light-emitting diode irradiation. response recovery times decreased ∼50 ∼28%, respectively, when system exposed UV light. sensing chips based on as-prepared TiO2/CoBDC-NH2 NTs exhibited highest-ranking performance, i.e., limit 1.3 ppb excellent even 100 concentration interference gases, owing synergistic chemical environment provided NH2-functionalized Co-MOFs abundant photogenerated electrons heterojunctions. This chip used practical application halitosis from direct study provides reliable design clinically aiding complex environment.

Language: Английский

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A Novel Z‐Scheme Heterostructured Bi₂S₃/Cu‐TCPP Nanocomposite with Synergistically Enhanced Therapeutics against Bacterial Biofilm Infections in Periodontitis

Small, Journal Year: 2023, Volume and Issue: 19(43)

Published: June 27, 2023

Porphyrin-based antibacterial photodynamic therapy (aPDT) has found widespread applications in treating periodontitis. However, its clinical use is limited by poor energy absorption, resulting reactive oxygen species (ROS) generation. To overcome this challenge, a novel Z-scheme heterostructured nanocomposite of Bi2 S3 /Cu-TCPP developed. This exhibits highly efficient light absorption and effective electron-hole separation, thanks to the presence heterostructures. The enhanced photocatalytic properties facilitate biofilm removal. Theoretical calculations confirm that interface readily adsorbs molecules hydroxyl radicals, thereby improving ROS production rates. Additionally, photothermal treatment (PTT) using nanoparticles promotes release Cu2+ ions, enhancing chemodynamic (CDT) effect facilitating eradication dense biofilms. Furthermore, released ions deplete glutathione bacterial cells, weakening their antioxidant defense mechanisms. synergistic aPDT/PTT/CDT demonstrates potent activity against periodontal pathogens, particularly animal models periodontitis, significant therapeutic effects, including inflammation alleviation bone preservation. Therefore, design semiconductor-sensitized transfer represents an important advancement aPDT efficacy inflammation.

Language: Английский

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Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: May 4, 2023

Treatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack antimicrobial activity titanium (Ti) implants. There a need to explore more effective approaches for treatment MRSA infections.Herein, an interfacial functionalization strategy proposed integration mesoporous polydopamine nanoparticles (PDA), nitric oxide (NO) release donor sodium nitroprusside (SNP) and osteogenic growth peptide (OGP) onto Ti implants, denoted as Ti-PDA@SNP-OGP. The physical chemical properties Ti-PDA@SNP-OGP were assessed scanning electron microscopy, X-ray photoelectron spectroscope, water contact angle, photothermal property NO behavior. synergistic antibacterial effect elimination biofilms evaluated 2',7'-dichlorofluorescein diacetate probe, 1-N-phenylnaphthylamine assay, adenosine triphosphate intensity, o-nitrophenyl-β-D-galactopyranoside hydrolysis activity, bicinchoninic acid leakage. Fluorescence staining, assays alkaline phosphatase collagen secretion extracellular matrix mineralization, quantitative real‑time reverse transcription‑polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA) used evaluate inflammatory response ability bone marrow stromal cells (MSCs), RAW264.7 their co-culture system. Giemsa ELISA, micro-CT, hematoxylin eosin, Masson's trichrome immunohistochemistry staining eradication biofilms, inhibition response, promotion osseointegration vivo.Ti-PDA@SNP-OGP displayed NO-dependent against following near-infrared light irradiation, effectively eliminated formed inducing reactive oxygen species (ROS)-mediated oxidative stress, destroying bacterial membrane integrity causing leakage intracellular components (P < 0.01). In vitro experiments revealed that not only facilitated differentiation MSCs, but also promoted polarization pro-inflammatory M1 macrophages anti-inflammatory M2-phenotype 0.05 or P favorable osteo-immune microenvironment further osteogenesis MSCs anti-inflammation via multiple paracrine signaling pathways vivo evaluation confirmed aforementioned results induced ameliorative MRSA-infected femoral defect implantation model 0.01).These findings suggest promising multi-functional material high-efficient replacement surgeries.

Language: Английский

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