Green and sustainable synthesis of nanomaterials: Recent advancements and limitations

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116316 - 116316

Published: June 1, 2023

Language: Английский

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Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 50 - 80

Published: Sept. 20, 2022

The site-specific delivery of antitumor agents is importance for providing effective cancer suppression. Poor bioavailability anticancer compounds and the presence biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. challenges chemotherapy stimuli-responsive nanocarriers are first described current review. Then, liposomes including pH-, redox-, enzyme-, light-, thermo- magneto-sensitive nanoparticles discussed potential drugs emphasized. pH- or redox-sensitive based on internal stimulus release drug response to a mildly acidic pH GSH, respectively. pH-sensitive mediate endosomal escape via proton sponge. multifunctional responsive both redox have more capacity at site compared alone. magnetic field NIR irradiation exploited external stimulation liposomes. light-responsive when they exposed irradiation; thermosensitive-liposomes temperature >40 °C there hyperthermia; magneto-responsive field. smart nanoliposomes also co-delivery genes synergistic therapy. Due lack long-term toxicity liposomes, utilized near future treatment patients.

Language: Английский

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Recent Trends in SERS-Based Plasmonic Sensors for Disease Diagnostics, Biomolecules Detection, and Machine Learning Techniques

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 328 - 328

Published: Feb. 27, 2023

Surface-enhanced Raman spectroscopy/scattering (SERS) has evolved into a popular tool for applications in biology and medicine owing to its ease-of-use, non-destructive, label-free approach. Advances plasmonics instrumentation have enabled the realization of SERS’s full potential trace detection biomolecules, disease diagnostics, monitoring. We provide brief review on recent developments SERS technique biosensing applications, with particular focus machine learning techniques used same. Initially, article discusses need plasmonic sensors advantage over existing techniques. In later sections, are organized as SERS-based diagnosis focusing cancer identification respiratory diseases, including SARS-CoV-2 detection. then discuss progress sensing microorganisms, such bacteria, detecting biohazardous materials view homeland security. At end article, we (a) identification, (b) classification, (c) quantification applications. The covers work from 2010 onwards, language is simplified suit needs interdisciplinary audience.

Language: Английский

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A multifunctional bioresponsive and fluorescent active nanogel composite for breast cancer therapy and bioimaging

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 6(1)

Published: Jan. 31, 2023

Abstract Bio-responsive nanocomposites with facile fabrication and rational design are of great importance in the diagnosis treatment cancer. Herein, combination bioimaging due to presence QD controlled drug delivery via nanogel was employed for cancer treatment. To this aim, we fabricated a traceable bioresponsive fluorescent active composite by integrating creatinine-functionalized carbon dots (QD) into lecithin-inulin nanogel. Subsequently, PEGylation integration herceptin on were carried out improve biofate its ability target HER2-positive breast The assessment cellular uptake demonstrated that effectively internalized SK-BR-3 cells production reactive oxygen species significantly boosted. Moreover, led high expression P53 Bax genes along low Bcl-2 gene (as promotors apoptosis signaling pathway). enhanced. It inhibiting proliferation as well reduction viability (HER-2 positive) compared MDA-MB-231 (triple-negative). intraperitoneal injection developed formulation MCF-7 cell-bearing BALB/c mice supported observation tumor growth inhibition. Overall, herceptin-adorned PEGylated can be promising theranostic candidate targeting HER-2-positive Graphical

Language: Английский

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Nanotechnology-empowered strategies in treatment of skin cancer

Environmental Research, Journal Year: 2023, Volume and Issue: 235, P. 116649 - 116649

Published: July 13, 2023

Language: Английский

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A new formulation of Ni/Zn bi-metallic nanocomposite and evaluation of its applications for pollution removal, photocatalytic, electrochemical sensing, and anti-breast cancer

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116462 - 116462

Published: June 22, 2023

Language: Английский

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Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 10, 2024

Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.

Language: Английский

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SOX2 function in cancers: Association with growth, invasion, stemness and therapy response

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113860 - 113860

Published: Oct. 20, 2022

Language: Английский

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CuMoO4 nanorods-based acetone chemiresistor-enabled non-invasive breathomic-diagnosis of human diabetes and environmental monitoring

Environmental Research, Journal Year: 2023, Volume and Issue: 229, P. 115931 - 115931

Published: April 17, 2023

Language: Английский

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The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116490 - 116490

Published: June 22, 2023

Language: Английский

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