SERS sensing for cancer biomarker: Approaches and directions

Bioactive Materials, Journal Year: 2023, Volume and Issue: 34, P. 248 - 268

Published: Dec. 31, 2023

These days, cancer is thought to be more than just one illness, with several complex subtypes that require different screening approaches. can distinguished by the distinct markings left metabolites, proteins, miRNA, and DNA. Personalized illness management may possible if categorized according its biomarkers. In order stop from spreading posing a significant risk patient survival, early detection prompt treatment are essential. Traditional techniques tedious, time-consuming, expert personnel for analysis. This has led scientists reevaluate methodologies make use of emerging technologies achieve better results. Using time money saving techniques, these integrate procedures sample preparation in small devices high accuracy sensitivity. With proven potential biomedical use, surface-enhanced Raman scattering (SERS) been widely used biosensing applications, particularly biomarker identification. Consideration was given especially SERS as portable clinical diagnostic tool. The approaches SERS-based sensing both invasive non-invasive samples reviewed this article, along obstacles. Aside constraints approach review also takes into account complexity biological fluids, availability biomarkers, their sensitivity selectivity, which generally lowered. Massive ways maintain capabilities being developed recently get over restriction. known reliable method judgments. Nonetheless, there still room advancement terms portability, creation apps, interdisciplinary AI-based applications. Therefore, we will outline current state technological maturity article. meet demand reviewing various types (invasive non-invasive) biomarkers using SERS. It shed light on growing body research methods application quick detection.

Language: Английский

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Design of biosensor for synchronized identification of diabetes using deep learning

Results in Engineering, Journal Year: 2023, Volume and Issue: 20, P. 101382 - 101382

Published: Sept. 3, 2023

A highly sensitive biosensor for the synchronized identification of diabetes is designed using a deep learning approach. The built on cutting-edge platform that combines nanotechnology with electrochemical processes. This makes it possible to diagnose accurately and quickly by detecting both in single test. novel creates very selective combining techniques. With high precision, this can identify presence glucose molecules blood. Also, differentiate between diabetes, which crucial precise diagnosis diabetes. far more than other techniques now use, detect levels at range 0.5–5 mmol per liter. study uses medical deep-learning model biosensor. significant development creation It will aid enhancing precision effectiveness diagnosis, enabling improved management condition. lower cost increasing accessibility individuals who require it. might be revolutionized new platform, making simpler efficient. In an evaluation point, proposed MDML achieved 96.21% accuracy, 91.53% 94.21% recall, 97.98% f1-score 89.90% diagnostic odds ratio.

Language: Английский

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Novel Digital SERS-Microfluidic Chip for Rapid and Accurate Quantification of Microorganisms

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(4), P. 1454 - 1461

Published: Jan. 15, 2024

In this work, we present a simple and novel digital surface-enhanced Raman spectroscopy (SERS)-microfluidic chip designed for the rapid accurate quantitative detection of microorganisms. The employs high-density inverted pyramid microcavity (IPM) array to separate isolate microbial samples. presence or absence target microorganisms is determined by scanning IPM using SERS identifying characteristic bands. This approach allows "digitization" response each IPM, enabling quantification through application mathematical statistical techniques. Significantly, precise yeast was achieved within concentration range 106–109 cells/mL, with maximum relative standard deviation from calibrated cultivation method being 5.6%. innovative efficiently addresses issue irregularities in detection, which arises due fluctuations intensity poor reproducibility. We strongly believe that SERS-microfluidic holds immense potential diverse applications various microorganisms, including pathogenic bacteria viruses.

Language: Английский

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Surface-enhanced Raman spectroscopy: a half-century historical perspective

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review comprehensively presents the fifty-year journey of surface-enhanced Raman spectroscopy (SERS), covering its discovery, pivotal phases, innovative methods, and key inspirations from pioneers trailblazers.

Language: Английский

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Plasmonic nanoparticle sensors: current progress, challenges, and future prospects

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(12), P. 2085 - 2166

Published: Jan. 1, 2024

This comprehensive review summarizes the past, present, and future of plasmonic NP-based sensors in terms different sensing platforms, chemical biological analytes, expected technologies.

Language: Английский

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Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Language: Английский

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Aptamers and antibodies in optical biosensing

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 24, 2025

Language: Английский

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Unveiling practical considerations for reliable and standardized SERS measurements: lessons from a comprehensive review of oblique angle deposition-fabricated silver nanorod array substrates

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 53(2), P. 1004 - 1057

Published: Dec. 20, 2023

Uncover the SERS secrets for silver nanorod substrates: to illustrate insights of growth, mechanisms, optimization, quality, storage, measurement, device, and manufacturing; address practical issues; unlock potential different applications.

Language: Английский

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Advances of machine learning-assisted small extracellular vesicles detection strategy

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 251, P. 116076 - 116076

Published: Feb. 1, 2024

Language: Английский

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Advances in machine learning-assisted SERS sensing towards food safety and biomedical analysis

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 117974 - 117974

Published: Sept. 1, 2024

Language: Английский

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