Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113965 - 113965
Published: May 14, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)
Published: March 6, 2024
Combination cancer immunotherapy based on electromagnetic energy and shows potent anti-cancer efficacy. However, as a factor that mediates tumor metastasis immune suppression, the impact of exosomes therapy under stimulation remains unclear. Herein, findings indicate sonodynamic (SDT) increases serum exosome levels by inducing apoptotic loosening extracellular matrix, promoting lung metastasis. To address this problem, an exosome-inhibiting polymeric sonosensitizer (EIPS) selectively inhibiting generation in response to biomarker is synthesized. EIPS consists semiconducting polymer backbone capable SDT poly(ethylene glycol) layer conjugated with tumor-specific enzyme-responsive inhibitor prodrug. After being cleaved Cathepsin B, releases active inhibitors, preventing exosome-mediated suppression As result, elicits robust antitumor effects through synergistic effect inhibition, completely establishing long-term memory effect. This first example showing combining inhibition can elicit without help typical agonists.
Language: Английский
Citations
22
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)
Published: March 23, 2024
Abstract Triple negative breast cancer (TNBCs), known as an immunologically cold tumor, is difficult to completely eliminate with existing monotherapies, let alone metastasis and recurrence. It urgent design a rational combination of multiple therapies programmatically reconstitute tumor microenvironment (TME) reverse the immune “cold” into “hot” inflammatory tumors improve therapeutic effect. Hence, in this work, multifunctional nanosystem (FeSH NPs) that integrates metal‐polyphenol coordination complex photothermal agent polyphenol, salvianolic acid B (SAB) immunomodulator designed fabricated for synergistic photothermal‐immunotherapy TNBCs combined anti‐PD‐L1 antibody. Guided by photothermal/photoacoustic dual‐mode imaging, therapy (PTT) caused FeSH NPs induces immunogenic cell death (ICD) under 808 nm laser irradiation. Subsequently, loaded SAB released addition deferoxamine mesylate (DFO) remodel TME, specifically TGF‐β inhibition PD‐L1 upregulation, primary tumors. The PTT TME reprogramming further synergizes antibody eradicate recurrence inhibit concurrently. Given biosafety throughout lifecycle, work provides protocol high clinical translational promise comprehensive programmed therapeutics TNBCs.
Language: Английский
Citations
19
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 21, 2024
Overcoming tumor apoptosis resistance is a major challenge in enhancing cancer therapy. Pyroptosis, lytic form of programmed cell death (PCD) involving inflammasomes, Gasdermin family proteins, and cysteine proteases, offers potential treatment. While photodynamic therapy (PDT) can induce pyroptosis by generating reactive oxygen species (ROS) through the activation photosensitizers (PSs), many PSs lack specific subcellular targets are limited to first near-infrared window, potentially reducing treatment effectiveness. Therefore, developing effective, deep-penetrating, organelle-targeted pyroptosis-mediated phototherapy essential for strategies. Here, we synthesized four molecules with varying benzene ring numbers thiopyrylium structures preliminarily explore their properties. The near-infrared-II (NIR-II) PS Z1, higher count, exhibited superior ROS generation mitochondria-targeting abilities, large Stokes shift. Through nano-precipitation method, Z1 nanoparticles (NPs) also demonstrated high (especially type-I ROS) upon 808 nm laser irradiation, leading efficient mitochondria dysfunction combined apoptosis. Moreover, they exceptional tumor-targeting ability via NIR-II fluorescence imaging (NIR-II FI) photoacoustic (PAI). Furthermore, NPs-mediated effectively inhibited growth minimal adverse effects. Our findings offer promising strategy therapy, warranting further preclinical investigations PDT.
Language: Английский
Citations
17
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
14
Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102314 - 102314
Published: May 18, 2024
Language: Английский
Citations
13
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(27)
Published: Feb. 25, 2024
Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl radicals (·OH) consuming H O for high‐efficiency chemodynamic therapy (CDT), while S has impressive photothermal (PTT). The synergistic benefits from parts further boosted CDT effect AAP high conversion efficiency up 56.8%. Moreover, multiple lines evidence supported that extremely faint fluorescence be significantly activated overexpressed levels , showing bright NIR‐II emission ≈1270 nm over 5.6 × 10 3 ‐fold increase signal intensity. are easily imaging tumor‐specific identification, effectively ablate tissues inhibition rate 96.2%. This study expects probe will open new route achieve window.
Language: Английский
Citations
12
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)
Published: May 1, 2024
Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives
Language: Английский
Citations
11
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7657 - 7680
Published: Jan. 1, 2024
Nanomaterials exhibit significant potential for stimulating immune responses, offering both local and systemic modulation across a variety of diseases. The lymphoid organs, such as the spleen lymph nodes, are home to various cells, including monocytes dendritic which contribute progression prevention/treatment Consequently, many nanomaterial formulations being rationally designed target these organs engage with specific cell types, thereby inducing therapeutic protective effects. In this review, we explore crucial cellular interactions processes involved in regulation highlight innovative nano-based immunomodulatory approaches. We outline essential considerations design an emphasis on their impact biological interactions, targeting capabilities, treatment efficacy. Through selected examples, illustrate strategic therapeutically active nanomaterials subsequent immunomodulation infection resistance, inflammation suppression, self-antigen tolerance, cancer immunotherapy. Additionally, address current challenges, discuss emerging topics, share our outlook future developments field.
Language: Английский
Citations
11
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Language: Английский
Citations
10
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(50)
Published: Aug. 15, 2024
Abstract New generation of nanomaterials with organelle‐level precision provide significant promise for targeted attacks on mitochondria, exhibiting remarkable therapeutic potency. Here, we report a novel amphiphilic phenolic polymer (PF) the mitochondria‐targeted photodynamic therapy (PDT), which can trigger excessive mitochondrial DNA (mtDNA) damage by synergistic action oxidative stress and furan‐mediated cross‐linking. Moreover, units PF enable further self‐assembly Mn 2+ via metal‐phenolic coordination to form nanomaterial (PFM). We focus activation cGAS‐STING pathway tumor‐derived mtDNA in tumor‐associated macrophages (TAMs), subsequently repolarizing M2‐like TAMs M1 phenotype. highlight that PFM facilitates cGAS‐STING‐dependent immunity at organelle level potent antitumor efficacy.
Language: Английский
Citations
9