Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 13, 2024
Abstract
Microwave
(MW)
therapy
is
an
emerging
with
high
efficiency
and
deep
penetration
to
combat
the
crisis
of
bacterial
resistance.
However,
as
energy
MW
too
low
induce
electron
transition,
mechanism
catalytic
effect
remains
ambiguous.
Herein,
a
cerium‐based
metal–organic
framework
(MOF)
fabricated
used
in
therapy.
The
MW‐catalytic
performance
CeTCPP
largely
dependent
on
ions
liquid
environment,
transition
achieved
through
“tribovoltaic
effect”
between
water
molecules
CeTCPP.
By
this
way,
can
generate
reactive
oxygen
species
(ROS)
saline
under
pulsed
irradiation,
showing
99.9995
±
0.0002%
antibacterial
ratio
against
Staphylococcus
aureus
(
S.
)
upon
two
cycles
irradiation.
Bacterial
metabolomics
further
demonstrates
that
diffusion
ROS
into
bacteria
led
metabolic
disorders.
are
finally
killed
due
“amino
acid
starvation”.
In
order
improve
applicability
CeTCPP,
It
incorporated
alginate‐based
hydrogel,
which
maintains
good
also
biocompatibility.
Therefore,
work
provides
comprehensive
instruction
using
therapy,
from
application.
This
new
perspectives
for
design
composite
hydrogel.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(30)
Published: May 4, 2024
Abstract
Low
efficacy
of
immunotherapy
due
to
the
poor
immunogenicity
most
tumors
and
their
insufficient
infiltration
by
immune
cells
highlights
importance
inducing
immunogenic
cell
death
activating
system
for
achieving
better
treatment
outcomes.
Herein,
ferroelectric
Bi
2
CuO
4
nanoparticles
with
rich
copper
vacancies
(named
BCO‐V
Cu
)
are
rationally
designed
engineered
ferroelectricity‐enhanced
apoptosis,
cuproptosis,
subsequently
evoked
immunotherapy.
In
this
structure,
suppressed
recombination
electron–hole
pairs
band
bending
polarization
lead
high
catalytic
activity,
triggering
reactive
oxygen
species
bursts
apoptosis.
The
fragments
produced
apoptosis
serve
as
antigens
activate
T
cells.
Moreover,
generated
charge
catalysis,
nanomedicine
can
act
“a
smart
switch”
open
membrane,
promote
nanomaterial
endocytosis,
shut
down
+
outflow
pathway
evoke
thus
a
strong
response
is
triggered
reduced
content
adenosine
triphosphate.
Ribonucleic
acid
transcription
tests
reveal
pathways
related
activation.
Thus,
study
firstly
demonstrates
feasible
strategy
enhancing
using
single
semiconductor‐induced
cuproptosis.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(13)
Published: Jan. 22, 2024
Abstract
Although
immunogenic
cell
death
(ICD)
inducers
evidently
enhance
the
effectiveness
of
immunotherapy,
their
potential
is
increasingly
restricted
by
development
apoptosis
resistance
in
tumor
cells,
poor
immunogenicity,
and
low
T‐cell
immune
responsiveness.
In
this
study,
for
first
time,
piezoelectrically
catalyzed
Mg
2+
‐doped
hydroxyapatite
(Mg‐HAP)
nanoparticles,
which
are
coated
with
a
mesoporous
silica
layer
loaded
ONC201
as
an
agonist
to
specifically
target
receptor
DR5
on
ultimately
developing
Mg‐HAP@MS/ONC201
nanoparticle
(MHMO
NP)
system,
engineered.
Owing
its
excellent
piezoelectric
properties,
MHMO
facilitates
release
significant
amount
reactive
oxygen
species
Ca
within
effectively
promoting
upregulation
expression
inducing
necroptosis
overcome
resistance.
Concurrently,
released
microenvironment
promotes
CD8
+
T
activation
response
antitumor
reaction
induced
ICD.
Using
RNA‐seq
analysis,
it
elucidated
that
can
activate
NF‐κB
pathway
under
catalysis,
thus
M1‐type
macrophage
polarization.
summary,
dual‐targeting
therapy
system
targets
both
cells
catalysis
designed.
This
holds
substantial
advancements
immunotherapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: April 10, 2024
Bioelectricity
plays
a
crucial
role
in
organisms,
being
closely
connected
to
neural
activity
and
physiological
processes.
Disruptions
the
nervous
system
can
lead
chaotic
ionic
currents
at
injured
site,
causing
disturbances
local
cellular
microenvironment,
impairing
biological
pathways,
resulting
loss
of
functions.
Electromagnetic
stimulation
has
ability
generate
internal
currents,
which
be
utilized
counter
tissue
damage
aid
restoration
movement
paralyzed
limbs.
By
incorporating
implanted
materials,
electromagnetic
targeted
more
accurately,
thereby
significantly
improving
effectiveness
safety
such
interventions.
Currently,
there
have
been
significant
advancements
development
numerous
promising
strategies
with
diverse
materials.
This
review
provides
comprehensive
summary
fundamental
theories,
modulating
material
application
strategies,
pre-clinical
therapeutic
effects
associated
for
repair.
It
offers
thorough
analysis
current
techniques
that
employ
materials
enhance
stimulation,
as
well
potential
future
applications.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 2, 2024
As
a
new
form
of
regulated
cell
death,
ferroptosis
has
unraveled
the
unsolicited
theory
intrinsic
apoptosis
resistance
by
cancer
cells.
The
molecular
mechanism
depends
on
induction
oxidative
stress
through
excessive
reactive
oxygen
species
accumulation
and
glutathione
depletion
to
damage
structural
integrity
Due
their
high
loading
tunability,
nanocarriers
can
escort
delivery
ferro-therapeutics
desired
site
enhanced
permeation
or
retention
effect
active
targeting.
This
review
shed
light
necessity
iron
in
growth
fascinating
features
regulating
cycle
metastasis.
Additionally,
we
discussed
ferroptosis-mediated
therapy
using
nanoplatforms
chemical
basis
overcoming
barriers
therapy.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(9)
Published: Dec. 8, 2023
Immunotherapy
using
an
immune-checkpoint
blockade
has
significantly
improved
its
therapeutic
effects.
CM-272,
which
is
a
novel
epigenetic
inhibitor
of
G9a,
induces
immunogenic
cell
death
(ICD)
for
recovering
the
sensitivity
to
anti-PD-1
antibodies;
however,
efficacy
CM-272
greatly
limited
by
promoting
transcription
activity
HIF-1α
form
hypoxic
environment.
Here,
Fe
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
Journal of Applied Physics,
Journal Year:
2025,
Volume and Issue:
137(5)
Published: Feb. 3, 2025
The
metalens
discussed
in
this
article
is
a
planar
optical
device
built
on
metasurfaces,
utilizing
precisely
engineered
subwavelength
nanostructured
wires
to
manipulate
electromagnetic
waves.
This
enables
precise
control
over
the
phase,
amplitude,
and
polarization
of
these
Recent
advancements
research
primarily
focus
their
design
principles,
performance
optimization,
imaging
enhancement,
manufacturing
techniques,
various
application
domains.
reviews
progress
development,
highlighting
principles
across
different
frequency
bands
applications
science
technology.
Future
directions
are
expected
emphasize
material
innovation,
simplification
processes,
further
improvements
drive
adoption
cutting-edge
fields.
