An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease DOI Creative Commons
Geraldine Kong, Susan Ellul, Vinod K. Narayana

et al.

Neurobiology of Disease, Journal Year: 2020, Volume and Issue: 148, P. 105199 - 105199

Published: Nov. 26, 2020

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms influenced by various environmental factors. Recent discoveries have highlighted the importance gastrointestinal microbiome in mediating gut-brain-axis bidirectional communication via circulating Using shotgun sequencing, we investigated gut composition R6/1 transgenic mouse model HD from 4 to 12 weeks age (early adolescent through adult stages). Targeted metabolomics was also performed on blood plasma these mice (n = 9 per group) at investigate potential effects dysbiosis metabolome profile.Modelled time profiles each species, KEGG Orthologs bacterial genes, revealed heightened volatility mice, indicating early mutation gut. In addition age, function perturbed. particular, butanoate metabolism pathway elevated, suggesting increased production protective SCFA, butyrate, No significant alterations were found butyrate propionate levels age. The statistical integration metagenomics unraveled several Bacteroides species that negatively correlated ATP pipecolic acid plasma.The present study instability during pre-motor symptomatic stage which may dire consequences host's health. Perturbation prior cognitive motor dysfunction suggest role modulating pathogenesis HD, potentially specific altered metabolites mediate gut-brain signaling.

Language: Английский

Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation DOI Creative Commons
Hui Wang, Feng Yang, Shidong Zhang

et al.

npj Parkinson s Disease, Journal Year: 2021, Volume and Issue: 7(1)

Published: Aug. 11, 2021

Abstract Neurodegenerative diseases are characterized by neuronal impairment and loss of function, with the major shared histopathological hallmarks misfolding aggregation specific proteins inside or outside cells. Some genetic environmental factors contribute to promotion development progression neurodegenerative diseases. Currently, there no effective treatments for It has been revealed that bidirectional communication exists between brain gut. The gut microbiota is a changeable experience-dependent ecosystem can be modified factors. provides potential therapeutic targets regulated as new interventions In this review, we discuss risk diseases, summarize among components microbiota-gut-brain axis, treatment strategy fecal transplantation (FMT). FMT promising restoration premorbid state novel goal prevention strategies.

Language: Английский

Citations

91
The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System DOI Open Access
Julia Doroszkiewicz, Magdalena Groblewska, Barbara Mroczko

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 10028 - 10028

Published: Sept. 17, 2021

The gut microbiome has attracted increasing attention from researchers in recent years. microbiota can have a specific and complex cross-talk with the host, particularly central nervous system (CNS), creating so-called “gut–brain axis”. Communication between gut, intestinal microbiota, brain involves secretion of various metabolites such as short-chain fatty acids (SCFAs), structural components bacteria, signaling molecules. Moreover, an imbalance composition modulates immune function tissue barriers blood–brain barrier (BBB). Therefore, aim this literature review is to describe how gut–brain interplay may contribute development neurological disorders, combining fields gastroenterology neuroscience. We present findings concerning effect altered on neurodegeneration neuroinflammation, including Alzheimer’s Parkinson’s diseases, well multiple sclerosis. impact pathological shift selected neuropsychological i.e., major depressive disorders (MDD) autism spectrum disorder (ASD), also discussed. Future research balanced axis would help identify new potential opportunities for therapeutic interventions presented diseases.

Language: Английский

Citations

91
The protective role of exercise against age-related neurodegeneration DOI
Alyson Sujkowski,

Luke Hong,

Robert Wessells

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 74, P. 101543 - 101543

Published: Dec. 17, 2021

Language: Английский

Citations

90
Is There an Exercise-Intensity Threshold Capable of Avoiding the Leaky Gut? DOI Creative Commons
Filipe M. Ribeiro, Bernardo Petriz, Gabriel Marques

et al.

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: March 8, 2021

Endurance-sport athletes have a high incidence of gastrointestinal disorders, compromising performance and impacting overall health status. An increase in several proinflammatory cytokines proteins (LPS, I-FABP, IL-6, IL-1β, TNF-α, IFN-γ, C-reactive protein) has been observed ultramarathoners triathlon athletes. One the most common effects this type physical activity is intestinal permeability, known as leaky gut. The mucosa's degradation can be identified analyzed by series molecular biomarkers, including lactulose/rhamnose ratio, occludin claudin (tight junctions), lipopolysaccharides, I-FABP. Identifying mechanisms involved induction gut exercise assist determination safe thresholds for preservation tract. It was recently shown that 60 min vigorous endurance training at 70% maximum work capacity led to characteristic responses believed other factors may contribute effect, such altitude, environmental temperature, fluid restriction, age trainability. On hand, moderate dietary interventions probiotics prebiotics improve microbiota composition. This review seeks discuss adaptation response role mitigating these effects.

Language: Английский

Citations

86
An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease DOI Creative Commons
Geraldine Kong, Susan Ellul, Vinod K. Narayana

et al.

Neurobiology of Disease, Journal Year: 2020, Volume and Issue: 148, P. 105199 - 105199

Published: Nov. 26, 2020

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms influenced by various environmental factors. Recent discoveries have highlighted the importance gastrointestinal microbiome in mediating gut-brain-axis bidirectional communication via circulating Using shotgun sequencing, we investigated gut composition R6/1 transgenic mouse model HD from 4 to 12 weeks age (early adolescent through adult stages). Targeted metabolomics was also performed on blood plasma these mice (n = 9 per group) at investigate potential effects dysbiosis metabolome profile.Modelled time profiles each species, KEGG Orthologs bacterial genes, revealed heightened volatility mice, indicating early mutation gut. In addition age, function perturbed. particular, butanoate metabolism pathway elevated, suggesting increased production protective SCFA, butyrate, No significant alterations were found butyrate propionate levels age. The statistical integration metagenomics unraveled several Bacteroides species that negatively correlated ATP pipecolic acid plasma.The present study instability during pre-motor symptomatic stage which may dire consequences host's health. Perturbation prior cognitive motor dysfunction suggest role modulating pathogenesis HD, potentially specific altered metabolites mediate gut-brain signaling.

Language: Английский

Citations

78