Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment DOI Creative Commons
Chen Chen, Bo Li, Haotian Chen

et al.

Neurochemical Research, Journal Year: 2022, Volume and Issue: 47(8), P. 2254 - 2262

Published: May 13, 2022

We aimed to explore the protective effects and potential treatment mechanism of Epigallocatechin-3-gallate (EGCG) in an animal model chronic exposure a natural high-altitude hypoxia (HAH) environment. Behavioral alterations were assessed with Morris water maze test. Iron accumulation hippocampus was detected by using DAB enhanced Perls' staining, MRI, qPCR colorimetry, respectively. Oxidative stress (malondialdehyde, MDA), apoptosis (Caspase-3), neural regeneration (brain-derived neurotrophic factor, BDNF) ELISA western blotting. Neural ultrastructural changes evaluated transmission electron microscopy (TEM). The results showed that learning memory performance rats decreased when HAH It followed iron accumulation, dysfunctional metabolism, reduced BDNF upregulation MDA Caspase-3. TEM confirmed neurons mitochondria. EGCG HAH-induced cognitive impairment, deposition, oxidative stress, promoted neuronal against HAH-mediated injury.

Language: Английский

Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment DOI Creative Commons
Marta Almería, Juan Carlos Cejudo, Javier Sotoca

et al.

Brain Behavior & Immunity - Health, Journal Year: 2020, Volume and Issue: 9, P. 100163 - 100163

Published: Oct. 23, 2020

Cognitive manifestations associated with the severity of a novel coronavirus (COVID-19) infection are unknown. An early detection neuropsychological could modify risk subsequent irreversible impairment and further neurocognitive decline.

Language: Английский

Citations

376
Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study DOI
Timothy D. Girard, Jennifer L. Thompson, Pratik P. Pandharipande

et al.

The Lancet Respiratory Medicine, Journal Year: 2018, Volume and Issue: 6(3), P. 213 - 222

Published: Feb. 26, 2018

Language: Английский

Citations

357
Applications of Functional Near-Infrared Spectroscopy (fNIRS) Neuroimaging in Exercise–Cognition Science: A Systematic, Methodology-Focused Review DOI Open Access
Fabian Herold, Patrick Wiegel, Felix Scholkmann

et al.

Journal of Clinical Medicine, Journal Year: 2018, Volume and Issue: 7(12), P. 466 - 466

Published: Nov. 22, 2018

For cognitive processes to function well, it is essential that the brain optimally supplied with oxygen and blood. In recent years, evidence has emerged suggesting cerebral oxygenation hemodynamics can be modified physical activity. To better understand relationship between oxygenation/hemodynamics, activity, cognition, application of state-of-the art neuroimaging tools essential. Functional near-infrared spectroscopy (fNIRS) such a tool especially suitable investigate effects activity/exercises on due its capability quantify changes in concentration oxygenated hemoglobin (oxyHb) deoxygenated (deoxyHb) non-invasively human brain. However, currently there no clear standardized procedure regarding application, data processing, analysis fNIRS, large heterogeneity how fNIRS applied field exercise–cognition science. Therefore, this review aims summarize current methodological knowledge about studies measuring cortical hemodynamic responses during testing (i) prior after different activities interventions, (ii) cross-sectional accounting for fitness level their participants. Based methodology 35 as relevant considered publications, we outline recommendations future

Language: Английский

Citations

357
Changes in cognitive functioning after COVID‐19: A systematic review and meta‐analysis DOI
Lucía Crivelli, Katie Palmer, Ismael Luis Calandri

et al.

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 18(5), P. 1047 - 1066

Published: March 17, 2022

Abstract Introduction We conducted a systematic review and meta‐analysis of the cognitive effects coronavirus disease 2019 (COVID‐19) in adults with no prior history impairment. Methods Searches Medline/Web Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews Meta‐Analyses (PRISMA) guidelines. A Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID‐19 healthy controls was performed. Results Oof 6202 articles, 27 studies 2049 individuals included (mean age = 56.05 years, evaluation time ranged acute phase 7 months post‐infection). Impairment executive functions, attention, memory found post‐COVID‐19 patients. The subgroup 290 showed difference MoCA between patients versus −0.94, 95% confidence interval [CI] −1.59, −0.29; P .0049). Discussion Patients have lower general cognition compared up post‐infection.

Language: Английский

Citations

263
Anesthetic Management Using Multiple Closed-loop Systems and Delayed Neurocognitive Recovery DOI Open Access
Alexandre Joosten, Joseph Rinehart,

Aurélie Bardaji

et al.

Anesthesiology, Journal Year: 2019, Volume and Issue: 132(2), P. 253 - 266

Published: Nov. 12, 2019

Cognitive changes after anesthesia and surgery represent a significant public health concern. We tested the hypothesis that, in patients 60 yr or older scheduled for noncardiac surgery, automated management of anesthetic depth, cardiac blood flow, protective lung ventilation using three independent controllers would outperform manual control these variables. Additionally, as result improved management, group experience less postoperative neurocognitive impairment compared to having standard, manually adjusted anesthesia.

Language: Английский

Citations

84
Silent hypoxaemia in COVID‐19 patients DOI Open Access
Tatum S. Simonson, Tracy L. Baker, Robert B. Banzett

et al.

The Journal of Physiology, Journal Year: 2020, Volume and Issue: 599(4), P. 1057 - 1065

Published: Dec. 22, 2020

The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable the majority patients having mild symptoms while others develop severe respiratory failure. reason for this variability unclear but in critical need investigation. Some have been labelled 'happy hypoxia', which patient complaints dyspnoea and observable signs distress are reported be absent. Based on ongoing debate, we highlight key neurological components that could underlie variation silent hypoxaemia define priorities subsequent

Language: Английский

Citations

82
Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives DOI Creative Commons
David M. Shaw,

Gus Cabre,

Nicholas Gant

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: May 17, 2021

Acute hypobaric hypoxia (HH) is a major physiological threat during high-altitude flight and operations. In military aviation, although hypoxia-related fatalities are rare, incidences common likely underreported. Hypoxia reduction in oxygen availability, which can impair brain function performance of operational safety-critical tasks. HH occurs at high altitude, due to the atmospheric pressure. This state also partially simulated normobaric environments for training research, by reducing fraction inspired achieve comparable tissue saturation [normobaric (NH)]. occur susceptible individuals below 10,000 ft (3,048 m) unpressurised aircrafts higher altitudes pressurised when life support systems malfunction or improper equipment use. Between 15,000 (4,572 m), mildly impaired hypoxic symptoms common, both often difficult accurately quantify, may partly be effects hypocapnia. Above ft, exponentially deteriorates with increasing altitude until loss consciousness. The period effective safe tasks following exposure termed time-of-useful-consciousness (TUC). Recovery lag beyond arterial reoxygenation could exacerbated repeated exposures hyperoxic recovery. review provides an overview basic physiology implications aviation discusses utility recognition training.

Language: Английский

Citations

78
The effects of long-term high-altitude exposure on cognition: A meta-analysis DOI
Rui Su,

Shurong Jia,

Niannian Zhang

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105682 - 105682

Published: April 19, 2024

Language: Английский

Citations

11
Neural basis for reduced executive performance with hypoxic exercise DOI
Genta Ochi,

Yuhki Yamada,

Kazuki Hyodo

et al.

NeuroImage, Journal Year: 2018, Volume and Issue: 171, P. 75 - 83

Published: Jan. 2, 2018

Language: Английский

Citations

66
Exaggerated systemic oxidative‐inflammatory‐nitrosative stress in chronic mountain sickness is associated with cognitive decline and depression DOI Open Access
Damian M. Bailey, Julien V. Brugniaux, Teresa Filipponi

et al.

The Journal of Physiology, Journal Year: 2018, Volume and Issue: 597(2), P. 611 - 629

Published: Nov. 6, 2018

Chronic mountain sickness (CMS) is a maladaptation syndrome encountered at high altitude (HA) characterised by severe hypoxaemia that carries higher risk of stroke and migraine associated with increased morbidity mortality. We examined if exaggerated oxidative-inflammatory-nitrosative stress (OXINOS) corresponding decrease in vascular nitric oxide bioavailability patients CMS (CMS+) impaired cerebrovascular function adverse neurological outcome. Systemic OXINOS was markedly elevated CMS+ compared to healthy HA (CMS-) low-altitude controls. blunted cerebral perfusion vasoreactivity hypercapnia, cognition and, CMS+, symptoms depression. These findings are the first suggest physiological continuum exists for hypoxaemia-induced systemic dwellers when excessive accelerated cognitive decline depression, helping identify those need more specialist assessment targeted support.

Language: Английский

Citations

65