Using Features Extracted From Upper Limb Reaching Tasks to Detect Parkinson’s Disease by Means of Machine Learning Models DOI Creative Commons
Giuseppe Cesarelli, Leandro Donisi, Francesco Amato

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2023, Volume and Issue: 31, P. 1056 - 1063

Published: Jan. 1, 2023

While in the literature there is much interest investigating lower limbs gait of patients affected by neurological diseases, such as Parkinson's Disease (PD), fewer publications involving upper movements are available. In previous studies, 24 motion signals (the so-called reaching tasks) PD and Healthy Controls (HCs) were used to extract several kinematic features through a custom-made software; conversely, aim our paper investigate possibility build models - using these for distinguishing from HCs. First, binary logistic regression and, then, Machine Learning (ML) analysis was performed implementing five algorithms Knime Analytics Platform. The ML twice: first, leave-one out-cross validation applied; wrapper feature selection method implemented identify best subset that could maximize accuracy. achieved an accuracy 90.5%, demonstrating importance maximum jerk during subjects limb motion; Hosmer-Lemeshow test supported validity this model (p-value=0.408). first high evaluation metrics overcoming 95% accuracy; second perfect classification with 100% both area under curve receiver operating characteristics. top-five terms acceleration, smoothness, duration, kurtosis. investigation carried out work has proved predictive power features, extracted tasks limbs, distinguish HCs patients.

Language: Английский

A dose–response meta-analysis of physical activity and the risk of alzheimer’s disease in prospective studies DOI

Yanjie Jiang,

Zhihui Jin,

Hanyu Wang

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 7, 2025

Language: Английский

Citations

1
Comparing the Impact of Various Exercise Modalities on Old Adults with Alzheimer's Disease: A Bayesian Network Meta-Analysis DOI

Fengting Hu,

Jinrong Peng,

Weiran Wang

et al.

Complementary Therapies in Clinical Practice, Journal Year: 2025, Volume and Issue: 59, P. 101968 - 101968

Published: March 11, 2025

Language: Английский

Citations

1
Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials DOI Creative Commons
Parnian Shobeiri, Amirali Karimi, Sara Momtazmanesh

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(3), P. e0264557 - e0264557

Published: March 3, 2022

Background Exercise training may affect the blood levels of brain-derived neurotrophic factor (BDNF), but meta-analyses have not yet been performed comparing pre- and post-intervention BDNF concentrations in patients with multiple sclerosis (PwMS). Objective To perform a meta-analysis to study influence exercise on define components that modulate them across clinical trials adults living (MS). Method Five databases (PubMed, EMBASE, Cochrane Library, PEDro database, CINAHL) were searched up June 2021. According Preferred Reporting Items for Systematic Reviews Meta-Analyses, we included 13 articles meta-analysis, including 271 subjects. investigate sources heterogeneity, subgroup analysis, meta-regression, sensitivity analysis conducted. We compare post-exercise peripheral PwMS. Results Post-exercise serum significantly higher than pre-intervention (Standardized Mean Difference (SMD): 0.33, 95% CI: [0.04; 0.61], p-value = 0.02). Meta-regression indicated quality studies based assessment tool might be source while no significant effect was found chronological age disease severity according expanded disability status scale. Conclusion This systematic review shows physical activity increases More research different modes PwMS is warranted.

Language: Английский

Citations

34
Blood levels of brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS): A systematic review and meta-analysis DOI

Nastaran Karimi,

Helia Ashourizadeh,

Boshra Akbarzadeh Pasha

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2022, Volume and Issue: 65, P. 103984 - 103984

Published: June 18, 2022

Language: Английский

Citations

32
Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer’s disease DOI Creative Commons
Andrea Elia, Silvia Fossati

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 30, 2023

The heart is a functional syncytium controlled by delicate and sophisticated balance ensured the tight coordination of its several cell subpopulations. Accordingly, cardiomyocytes together with surrounding microenvironment participate in tissue homeostasis. In right atrium, sinoatrial nodal cells regulate cardiac impulse propagation through cardiomyocytes, thus ensuring maintenance electric network tissue. Notably, central nervous system (CNS) modulates rhythm two limbs autonomic (ANS): parasympathetic sympathetic compartments. exerts non-voluntary effects on different peripheral organs. main neuromodulator Sympathetic Nervous System (SNS) norepinephrine, while principal neurotransmitter Parasympathetic (PNS) acetylcholine. Through these neurohormones, ANS can gradually cardiac, vascular, visceral, glandular functions turning one branches (adrenergic and/or cholinergic), which exert opposite targeted Besides neuromodulators, ruled specific neuropeptides (neurotrophic factors) that help to preserve innervation homeostasis myocardial layers (from epicardium endocardium). Interestingly, dysregulation this neuro-signaling pathway may expose severe disorders etiology nature. Specifically, maladaptive remodeling culminate progressive loss neurotrophins, leading denervation, as observed cardiometabolic neurodegenerative diseases (myocardial infarction, failure, Alzheimer's disease). This review analyzes current knowledge pathophysiological processes involved impairment from perspectives both widely diffused devastating disorder, disease, proposing relationship between neurodegeneration, neurotrophic factors, impairment. overview conducive more comprehensive understanding process dysfunction, bringing light potential therapeutic scenarios correct or delay adverse cardiovascular remodeling, improving prognosis quality life patients disorders.

Language: Английский

Citations

19
Aerobic exercise, an effective prevention and treatment for mild cognitive impairment DOI Creative Commons

Baiqing Huang,

Kang Chen, Ying Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Aug. 8, 2023

Aerobic exercise has emerged as a promising intervention for mild cognitive impairment (MCI), precursor to dementia. The therapeutic benefits of aerobic are multifaceted, encompassing both clinical and molecular domains. Clinically, been shown mitigate hypertension type 2 diabetes mellitus, conditions that significantly elevate the risk MCI. Moreover, it stimulates release nitric oxide, enhancing arterial elasticity reducing blood pressure. At level, is hypothesized modulates activation microglia astrocytes, cells crucial brain inflammation neurogenesis, respectively. It also suggested promotes factors such irisin, cathepsin B, CLU, GPLD1, which could enhance synaptic plasticity neuroprotection. Consequently, regular potentially prevent or reduce likelihood MCI development in elderly individuals. These mechanisms, however, hypotheses require further validation. mechanisms action intricate, research needed elucidate precise underpinnings develop targeted therapeutics

Language: Английский

Citations

17
Neuroplasticity in Parkinson’s disease DOI Creative Commons
Bogdan Ovidiu Popescu, Lucia Batzu, Pedro Ruiz

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(11), P. 1329 - 1339

Published: Aug. 5, 2024

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting millions of people and rapidly increasing over last decades. Even though there no intervention yet to stop pathology, many efficient treatment methods are available, including for patients with advanced PD. Neuroplasticity a fundamental property human brain adapt both external changes internal insults pathological processes. In this paper we examine current knowledge concepts concerning at network level, cellular level molecular as parts neuroplastic response protein aggregation synapse loss neuronal in We analyse beneficial, compensatory effects, such augmentation nigral neurons efficacy, well negative, maladaptive levodopa-induced dyskinesia. Effects physical activity different treatments on neuroplasticity considered opportunity biomarkers identification use discussed.

Language: Английский

Citations

8
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF DOI

Can-Can Wang,

Xinmei Hu,

Yufei Long

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 356, P. 123014 - 123014

Published: Aug. 24, 2024

Language: Английский

Citations

7
Targeting brain‐derived neurotrophic factor in the treatment of neurodegenerative diseases: A review DOI Creative Commons
Dong Wang,

Zhi‐Chen Lang,

Shi‐Nan Wei

et al.

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2024, Volume and Issue: 2(2), P. 67 - 78

Published: May 2, 2024

Abstract Neurodegenerative diseases, marked by the gradual death of neurons, present a significant and growing public health challenge. Brain‐derived neurotrophic factor (BDNF) is crucial for survival, development, synaptic plasticity neurons. Studies have consistently demonstrated that perturbed BDNF communication pathways are associated with development progression neurodegenerative conditions, underscoring their potential as therapeutic targets. This review aimed to summarize existing findings regarding expression, metabolism, signaling transduction. Furthermore, we reviewed intricate roles in elucidating contributions disease onset progression. The latest advancements targeting treatment including small molecules, nucleic acid‐based therapeutics, antibody‐based approaches, were also summarized. Despite recent strides, challenges persist, lack comprehensive understanding modulation across diverse contexts absence clinically approved BDNF‐targeted drugs.

Language: Английский

Citations

6
Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain DOI Creative Commons
Hiroyuki Umegaki, Takashi Sakurai, Hidenori Arai

et al.

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Nov. 30, 2021

A growing body of evidence clearly indicates the beneficial effects physical activity (PA) on cognition. The importance PA is now being reevaluated due to increase in sedentary behavior older adults during COVID-19 pandemic. Although many studies humans have revealed that helps preserve brain health, underlying mechanisms not yet been fully elucidated. In this review, which mainly focuses humans, we comprehensively summarize or exercise particularly most intensively studied involve an brain-derived neurotrophic factor (BDNF) and preservation volume, especially hippocampus. Nonetheless, mutual associations between these two factors remain unclear. For example, although BDNF presumably affects volume by inhibiting neuronal death and/or increasing neurogenesis, human data issue are scarce. It also remains be determined whether modulates amyloid tau metabolism. However, recent advances blood-based biomarkers expected help elucidate brain. Clinical suggest functionally cognition independently neurodegeneration, involved include modulation functional connectivity, compensation, resource allocation, efficiency. as understood. clear understanding could motivate inactive persons change their behavior. More accumulation field awaited.

Language: Английский

Citations

35