Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study DOI Creative Commons
Mingkai Li, Chenyang Li,

Le Cheng

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 12, 2025

Background Biological aging, a fundamental process affecting health and longevity, is pivotal to understanding the physiological decline associated with aging. Serum vitamin D3 deficiency cognitive impairment are common issues among older adults. However, joint associations of serum D levels biological aging remain poorly understood. This study aims evaluate independent combined in Methods cross-sectional included adults aged 60 years from 2011–2014 National Health Nutrition Examination Survey (NHANES). was measured using Phenotypic Age calculated biomarkers. Cognitive performance assessed Centre for Establishment Registry Alzheimer’s Disease (CERAD) test, Animal Fluency test (AFT), Digit Symbol Substitution (DSST). Multivariable regression restricted cubic spline models were used examine relationships between 25(OH)D3 levels, performance, Results After adjusting all covariates, individuals highest quartile had reduced risk compared those lowest (CERAD: OR 0.91; 95% CI, 0.57–1.46; AFT: 0.48; 0.29–0.82; DSST: 0.43; 0.24–0.77). A U-shaped relationship observed Combined analyses revealed that both low across tests 1.43; 1.02–1.98; 1.70; 1.24–2.32; 1.67; 1.22–2.27). Notably, DSST, normal showed reduction by 2.40 ( p < 0.01). Conclusion In adults, strongly an increased

Language: Английский

Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes DOI Creative Commons
Xiaoyu Zhang, Chuanying Chen, Yi Liu

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 23, 2024

Abstract Alzheimer’s disease (AD) is the most common cause of dementia, and its underlying mechanisms have been a subject great interest. The mainstream theory AD pathology suggests that primarily associated with tau protein amyloid-beta (Aβ). However, an increasing body research has revealed abnormalities in lipid metabolism may be important event throughout pathophysiology AD. Astrocytes, as members network brain, play significant role this event. study abnormal astrocytes provides new perspective for understanding pathogenesis This review focuses on fatty acids (FAs) cholesterol AD, discusses it from three perspectives: uptake, intracellular breakdown or synthesis metabolism, efflux transport. We found that, despite accumulation their own acids, cannot efficiently uptake neurons, leading to acid within neurons resulting lipotoxicity. In terms exhibit decrease endogenous due exogenous cholesterol. Through thorough investigation these metabolic abnormalities, we can provide insights future therapeutic strategies by literature navigate complex maze bring hope patients disease.

Language: Английский

Citations

6
Effects of a Multicomponent Intervention With Cognitive Training and Lifestyle Guidance for Older Adults at Risk of Dementia DOI Open Access
Pengfei Wang, Tingting Yang, Wenjia Peng

et al.

The Journal of Clinical Psychiatry, Journal Year: 2024, Volume and Issue: 85(2)

Published: May 13, 2024

This study examined the effects of a multicomponent intervention program on cognitive function in community-dwelling older adults with mild impairment (MCI) and subjective decline (SCD).

Language: Английский

Citations

6
Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease DOI
Ujala Sehar, Upasana Mukherjee,

Hafiz Khan

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102397 - 102397

Published: June 27, 2024

Language: Английский

Citations

6
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer’s disease DOI Creative Commons
Annalise Schweickart, Richa Batra, Bryan J. Neth

et al.

npj Metabolic Health and Disease, Journal Year: 2024, Volume and Issue: 2(1)

Published: July 1, 2024

Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only few studies have explored KD's impact, especially on blood cerebrospinal fluid (CSF). Our study involved participants at for AD, either cognitively normal or with mild cognitive impairment. The consumed both modified Mediterranean Ketogenic Diet (MMKD) American Heart Association (AHAD) 6 weeks each, separated 6-week washout period. We employed nuclear magnetic resonance (NMR)-based metabolomics to profile serum CSF metagenomics profiling fecal samples. AHAD induced no notable changes, MMKD led significant alterations CSF. These changes included improved like increased HDL-C reduced BMI, reversed disturbances linked such as microbiome-mediated increase valine levels, reduction systemic inflammation. Additionally, was amino acid levels CSF, breakdown branched-chain acids (BCAAs), decreased levels. Importantly, we observed strong correlation between serum, suggesting regulation metabolism. findings highlight that can improve AD-related reverse some associated align across blood-CSF barrier.

Language: Английский

Citations

6
A comprehensive review on the prevention and regulation of Alzheimer’s disease by tea and its active ingredients DOI

Yi Huang,

Yang Wei, Jia Xu

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(30), P. 10560 - 10584

Published: June 1, 2022

Alzheimer's disease (AD) has brought a heavy burden to society as representative neurodegenerative disease. The etiology of AD combines multiple factors, concluding family, gender, head trauma, diseases and social psychology. There are hypotheses explaining the pathogenesis such β-amyloid (Aβ) deposition tau hyperphosphorylation, which lead extracellular amyloid plaques neurofibrillary tangles in neurons. existing therapeutic drugs have several disadvantages including single target, poor curative effect, obvious side effects. Tea contains many bioactive components, tea polyphenols (TPP), L-theanine (L-TH), pigment, polysaccharides caffeine. epidemiological investigations shown that drinking can reduce risk AD. mechanisms active ingredients prevention regulation includes reducing generation aggregation Aβ; inhibiting hyperphosphorylation; neuronal apoptosis regulate neurotransmitters; relieving oxidative stress neuroinflammation well intestinal flora. This review summarizes different signaling pathways Furthermore, we propose main limitations current research future directions, hoping contribute development natural functional foods based on treatment

Language: Английский

Citations

25
Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives DOI
Linli Bu, Chen Wang, Junying Bai

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(3), P. 1116 - 1134

Published: Jan. 1, 2024

Cognitive impairment (CI) is a multifaceted neurological condition that can trigger negative emotions and range of concurrent symptoms, imposing significant public health economic burdens on society.

Language: Английский

Citations

5
Gut Microbiome in Alzheimer’s Disease: from Mice to Humans DOI

Chang Liang,

Resel Pereira,

Yan Zhang

et al.

Current Neuropharmacology, Journal Year: 2024, Volume and Issue: 22(14), P. 2314 - 2329

Published: March 16, 2024

Alzheimer's disease (AD) is the most prevalent type of dementia, but its etiopathogenesis not yet fully understood. Recent preclinical studies and clinical evidence indicate that changes in gut microbiome could potentially play a role accumulation amyloid beta. However, relationship between dysbiosis AD still elusive. In this review, potential impact on development progression discussed. Pre-clinical literature exploring composition assessed, which can contribute to pathology including increased beta deposition cognitive impairment. The gut-brain axis involvement metabolites produced by are also highlighted. Furthermore, antibiotics, prebiotics, probiotics, fecal microbiota transplantation, dietary interventions as complementary therapies for management summarized. This review provides valuable insights into therapeutic strategies modulate AD.

Language: Английский

Citations

5
Nutrients and amyloid β status in the brain: A narrative review DOI Creative Commons
Gustavo Díaz, Laetitia Lengelé,

Sandrine Sourdet

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101728 - 101728

Published: Aug. 30, 2022

Amyloid beta (Aβ) is a peptide and hallmark of Alzheimer's disease (AD). Emerging evidence suggests that Aβ levels could be influenced by diet. However, the sparse for some nutrients, controversial. The aim this narrative review to gather findings observational clinical trials involving human participants on relationships between nutrients brain status. Some dietary patterns are associated reduced in brain, such as Mediterranean diet, ketogenic diet well low intake saturated fat, high-glycemic-index food, sodium, junk/fast food. Low status was also with higher density lipoproteins (HDL) cholesterol polyunsaturated fatty acids consumption. Data alcohol not conclusive. On contrary, high were related total cholesterol, triglycerides, low-density (LDL) sucrose, fructose. Folic acid, cobalamin, vitamin E, D status, while blood concentrations Calcium, Aluminum, Zinc, Copper, Manganese decreased but cerebral spinal fluid (CSF) concentrations. In conclusion, certain Further research association needed order pave way use nutritional interventions efficacious strategies prevent disturbance potentially AD.

Language: Английский

Citations

20
Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice DOI Creative Commons

Yuhang Sun,

Wu Yao, Bing Fang

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 792 - 792

Published: Feb. 26, 2025

The mechanism of egg yolk phosphatidylcholine (PC) in alleviating Alzheimer's disease (AD) has not yet been clear. fatty acid composition PC, especially the ratio polyunsaturated acids (PUFA), may be a critical determinant their structural and functional roles. This study aimed to conduct comparative analysis unsaturation levels PC impact on neurological health murine model AD. results showed that oral administration high low (HUP, LUP) enhanced learning memory abilities AD mice, with HUP intervention demonstrating superior efficacy compared LUP. Follow-up biochemical brain tissue also suggested effectively mitigated oxidative-stress damage inhibited tau hyperphosphorylation mice. Meanwhile, lipidomic analyses mouse hippocampus revealed substantially increased phospholipids, such as PEt (phosphatidylethanol) BisMePA (bis(methylthio)phenylacetic acid), which are recognized vital components neuronal cell membranes. Furthermore, markedly elevated phospholipids incorporating PUFAs hippocampus. These mitigating role for unsaturated prevention offer new insights into from perspective.

Language: Английский

Citations

0
Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies—A Narrative Review DOI Open Access

Tudor-Florentin Capatina,

Anamaria Oatu,

Casandra Babasan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4285 - 4285

Published: May 1, 2025

In this review, we explore the biomarkers of different psychiatric disorders, such as major depressive disorder, generalized anxiety schizophrenia, and bipolar disorder. Moreover, show interplay between genetic environmental factors. Novel techniques genome-wide association studies (GWASs) have identified numerous risk loci single-nucleotide polymorphisms (SNPs) implicated in these conditions, contributing to a better understanding their mechanisms. impact variations on drug metabolisms, particularly through cytochrome P450 (CYP450) enzymes, highlights importance pharmacogenomics optimizing treatment. This review also explores role neurotransmitter regulation, immune system interactions, metabolic pathways disorders. As technology advances, integrating markers into clinical practice will be crucial advancing precision psychiatry, improving diagnostic accuracy therapeutic interventions for individual patients.

Language: Английский

Citations

0