CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations DOI Creative Commons
Martı́n Cammarota, Janine I. Rossato, María Carolina González

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Object recognition memory (ORM) allows animals to distinguish between novel and familiar items. When reactivated during recall in the presence of a object, consolidated ORM can be destabilized linked that generated by object through reconsolidation. The CA1 region dorsal hippocampus contributes destabilization reconsolidation mechanisms involving theta/gamma cross-frequency coupling (hPAC) synaptic plasticity modulation. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is vital for hippocampus-dependent processing has been associated with theta activity-dependent CA1. However, specific role hippocampal CaMKII lasting storage remains unclear, its potential impact on memory-related oscillatory activity not previously investigated. To explore these questions, we employed combination behavioral, electrophysiological, pharmacological approaches at various stages processing, found necessary or but does regulate novelty-induced modulating hPAC.

Language: Английский

Rodents’ visual gamma as a biomarker of pathological neural conditions DOI
Nicolò Meneghetti, Eleonora Vannini, Alberto Mazzoni

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(6), P. 1017 - 1048

Published: Feb. 19, 2024

Abstract Neural gamma oscillations (indicatively 30–100 Hz) are ubiquitous: they associated with a broad range of functions in multiple cortical areas and across many animal species. Experimental computational works established rhythms as global emergent property neuronal networks generated by the balanced coordinated interaction excitation inhibition. Coherently, activity is strongly influenced alterations synaptic dynamics which often pathological neural dysfunctions. We argue therefore that these an optimal biomarker for probing mechanism Gamma also highly sensitive to external stimuli sensory cortices, especially primary visual cortex (V1), where stimulus dependence has been thoroughly investigated. manipulation tuning particularly easy rodents, have become standard model investigating effects network on oscillations. Overall, rodents’ offers accessible probe dysfunctional information processing conditions. Beyond vision‐related dysfunctions, rodents were indeed reported deficits such migraine, epilepsy neurodegenerative or neuropsychiatric conditions Alzheimer's, schizophrenia autism spectrum disorders. Altogether, connections between physio‐pathological rodent models underscore potential markers (dys)functioning. image

Language: Английский

Citations

2
The role of aberrant neural oscillations in the hippocampal-medial prefrontal cortex circuit in neurodevelopmental and neurological disorders DOI
Nathanael Shing, Matthew C. Walker, Pishan Chang

et al.

Neurobiology of Learning and Memory, Journal Year: 2022, Volume and Issue: 195, P. 107683 - 107683

Published: Sept. 26, 2022

Language: Английский

Citations

11
Multiple cross-frequency coupling analysis of resting-state EEG in patients with mild cognitive impairment and Alzheimer’s disease DOI Creative Commons
Xi Chen, Yingjie Li, Renren Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Aug. 4, 2023

Electroencephalographic (EEG) abnormalities are seen in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) characteristic features of impairment. The most common findings EEG AD MCI increased relative power slow oscillations (delta theta rhythms) decreased fast (alpha, beta gamma rhythms). However, impairments processes not sufficiently reflected by brain oscillatory activity a particular frequency band. at high risk progressing to AD. Cross-frequency coupling (CFC), which refers between different bands, is crucial tool for comprehending changes performance. CFC exhibit some specificity MCI, but comparison individuals these disorders still lacking. aim this study was explore properties the relationship multiple types functional performance.We recorded resting-state (rsEEG) signals 46 patients, 43 cognitively healthy controls (HCs) analyzed as well scores on clinical tests function.Multiple couplings low-frequency high-frequency were found be significantly enhanced compared those HCs while delta-gamma theta-gamma right temporal parietal lobes HCs. Moreover, lobe tended stronger than HCs, it MCI. Multiple correlate various domains, especially memory function domain. Overall, suggest that must use more neural resources maintain resting state alterations become progressively obvious during progression likely valuable indicator pathology.

Language: Английский

Citations

3
A qualitative exploration of 40 Hz sound and music for older adults with mild cognitive impairment DOI
Claire Wang, Mengchi Li, Sarah L. Szanton

et al.

Geriatric Nursing, Journal Year: 2024, Volume and Issue: 56, P. 259 - 269

Published: Feb. 24, 2024

Language: Английский

Citations

1
Olfactory bulb stimulation mitigates Alzheimer’s-like disease progression DOI Open Access
Morteza Salimi, Milad Nazari,

Payam Shahsavar

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 6, 2024

Abstract Background Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer’s disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD-related changes and extensive connections with memory regions, offers an attractive entry point intervention, potentially restoring normal activity deteriorating circuits. Aims Our study examined impact electrically stimulating OB on working as well pathological electrophysiological alterations OB, medial prefrontal cortex, hippocampus, entorhinal cortex amyloid beta (Aβ) AD model rats. Methods Male Wistar rats underwent surgery electrode implantation inducing Alzheimer’s-like disease. Bilateral (OB) electrical was performed 1 hour daily to group animals 18 consecutive days, followed by evaluations histological, behavioral, local field signal processing. Results counteracted Aβ plaque accumulation prevented AD-induced impairments. Furthermore, it prompted increase power across diverse frequency bands enhanced functional connectivity, particularly gamma band, within investigated regions during a task. Conclusion This preclinical investigation highlights pathway-based modulate deep-seated networks treatment. Importantly, accessibility this pathway via nasal cavity lays groundwork development minimally approaches targeting modulation.

Language: Английский

Citations

1
Evaluation of variation in preclinical electroencephalographic (EEG) spectral power across multiple laboratories and experiments: An EQIPD study DOI Creative Commons
Tim P. Ahuis, Magdalena K. Smyk,

Clément Laloux

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0309521 - e0309521

Published: Oct. 29, 2024

The European Quality In Preclinical Data (EQIPD) consortium was born from the fact that publications report challenges with robustness, rigor, and/or validity of research data, which may impact decisions about whether to proceed further preclinical testing or advance clinical testing, as well draw conclusions on predictability models. To address this, a including multiple laboratories academia and industry participated in series electroencephalography (EEG) experiments mice aimed detect sources variance gauge how protocol harmonisation data analytics such variance. Ultimately, goal this first ever between-laboratory comparison EEG recordings analyses validate principles supposedly increase quality, comparability. Experiments consisted Localisation phase, identify factors influence variability, Harmonisation phase evaluate standardized protocols centralised processing analysis reduced variance, Ring-Testing verify ability harmonised generate consistent findings. Indeed, variability reduction remained during phase. Results obtained multicentre qEEG study also confirmed complex nature starting surgery collection through pre-processing ultimately influenced results contributed findings across laboratories. Overall, centralized were crucial reducing laboratory-to-laboratory variability. end, it is recommended guidelines be updated followed for data.

Language: Английский

Citations

1
Electrophysiological Insights into Alzheimer's Disease: A Review of Human and Animal Studies DOI

Kirsten N. Calvin-Dunn,

Adam M. McNeela,

Amanda Leisgang Osse

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 105987 - 105987

Published: Dec. 1, 2024

Language: Английский

Citations

1
Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model DOI Open Access
Marisol Soula, Anna Maslarova, Ryan E. Harvey

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 15, 2023

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but also present other neurological disease, such as Alzheimer's Disease (AD). Understanding the role IEDs have on hippocampal circuit is important for our understanding of cognitive deficits seen and AD. We characterize compare human from microwire recording with those AD transgenic mice implanted multi-layer silicon probes. Both local field potential features firing patterns pyramidal cells interneurons were similar mouse human. found that emerged CA3-1 circuits, they recruited silenced interneurons, followed by post-IED suppression. suppressed incidence altered properties physiological sharp-wave ripples (SPW-Rs), their properties, interfered replay place sequences a maze. In addition, inversely correlated daily memory performance. Together, work implicates may common epilepsy-independent phenomenon neurodegenerative diseases perturbs hippocampal-cortical communication interferes memory.Prevalence number people dementia increasing steadily. Therefore, novel treatment strategies learning disorders urgently necessary. IEDs, apart being surrogate epileptic brain regions, been linked to decline. Here we report models characteristics associated interneurons. Mice more displayed fewer SPW-Rs, poorer spatial trajectories, decreased IED suppression an unexplored target treat dysfunction diseases.

Language: Английский

Citations

3
Cognitive improvement via a modulated rhythmic pulsed magnetic field in D-galactose-induced accelerated aging mice DOI
Pingping Wang, Xue Wang,

Qingmeng Wang

et al.

Brain Research, Journal Year: 2023, Volume and Issue: 1810, P. 148372 - 148372

Published: April 23, 2023

Language: Английский

Citations

2
Compulsive-like Behaviors in Amyloid-β 1-42–Induced Alzheimer’s Disease in Mice Are Associated With Hippocampo-cortical Neural Circuit Dysfunction DOI Creative Commons

Apoorva Bettagere Shivakumar,

Sparsha Kumari,

Sonam Fathima Mehak

et al.

Biological Psychiatry Global Open Science, Journal Year: 2023, Volume and Issue: 3(4), P. 773 - 784

Published: March 7, 2023

In addition to memory deficits, patients with Alzheimer's disease (AD) experience neuropsychiatric disturbances. Recent studies have suggested the association of obsessive-compulsive disorder early stages AD. However, there is a lack understanding neurobiological underpinnings compulsive-like behaviors at neuronal circuit level and their relationship AD.We addressed this issue in an amyloid-β 1-42-induced mouse model AD by studying behaviors. Next, we compared hippocampal medial prefrontal cortex (mPFC) local field potential pattern coherence between these regions control mice. We also assessed expression acetylcholine glutamatergic signaling regions, using quantitative polymerase chain reaction.Our findings show that mice exhibit behaviors, as evidenced enhanced marble burying, nest building, burrowing. Furthermore, exhibited hippocampo-cortical dysfunction demonstrated decreased power rhythmic oscillations theta (4-12 Hz) gamma (25-50 frequencies hippocampus mPFC, two functionally interconnected brain involved both compulsive Importantly, mPFC band animals was significantly reduced. found reduced cholinergic neurotransmission mice.We conclude functional alterations may play significant role mediating observed These help underlying mechanisms disorder-like phenotypes associated

Language: Английский

Citations

2