Gut Microbiota, Inflammation, and Probiotics on Neural Development in Autism Spectrum Disorder

Neuroscience, Journal Year: 2018, Volume and Issue: 374, P. 271 - 286

Published: Feb. 8, 2018

Language: Английский

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Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(1), P. 710 - 730

Published: May 17, 2021

Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin studies demonstrate high heritability 60-90%, indicating a predominant role genetics in development disorder. The genetic architecture ASD consists complex array rare common variants all classes variation usually acting additively to augment individual risk. relative contribution heredity persists despite selective pressures against classic autistic phenotype; phenomenon thought be explained, part, by incidence spontaneous (or de novo) mutations. Notably, environmental exposures attributed as salient risk factors for may play causal emergence deleterious novo variations, with several ASD-associated agents having significant mutagenic potential. To explore this hypothesis, review article assesses published epidemiological data evidence derived from assays mutagenicity, both vivo vitro, determine likely such augmenting liability ASD. Broadly, these were observed elicit genomic alterations through one or combination of: (1) direct interaction material; (2) impaired DNA repair; (3) oxidative damage. However, phenotype cannot determined without further analysis. comprehensive prospective birth cohorts genome sequencing essential forming causal, mechanistic account mutations that links exposure, genotypic alterations, phenotypic consequences.

Language: Английский

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Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift

Journal of Personalized Medicine, Journal Year: 2021, Volume and Issue: 11(2), P. 70 - 70

Published: Jan. 25, 2021

The wide spectrum of unique needs and strengths Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With plethora information from research, common thread required to conceptualize an exhaustive pathogenetic paradigm. epidemiological clinical findings in ASD cannot be explained by traditional linear genetic model, hence need move towards more fluid conception, integrating genetics, environment, epigenetics as whole. embryo-fetal period first two years life (the so-called ‘First 1000 Days’) are crucial time window neurodevelopment. In particular, interplay vicious loop between immune activation, gut dysbiosis, mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy undermines health people throughout life. Consequently, most effective intervention expected primary prevention aimed at early control main effector molecular pathways. We will reason here on comprehensive paradigm ASD, viewed not just theoretical issue, but tool provide suggestions preventive strategies personalized, dynamic (from womb adulthood), systemic, interdisciplinary approach.

Language: Английский

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Multiple neurological effects associated with exposure to organophosphorus pesticides in man

Toxicology, Journal Year: 2022, Volume and Issue: 484, P. 153407 - 153407

Published: Dec. 18, 2022

Language: Английский

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Atrazine and its degradation products in drinking water source and supply: Risk assessment for environmental and human health in Campinas, Brazil

Chemosphere, Journal Year: 2023, Volume and Issue: 336, P. 139289 - 139289

Published: June 20, 2023

Language: Английский

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Are endocrine disrupting compounds environmental risk factors for autism spectrum disorder?

Hormones and Behavior, Journal Year: 2017, Volume and Issue: 101, P. 13 - 21

Published: Oct. 24, 2017

Language: Английский

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Children’s low-level pesticide exposure and associations with autism and ADHD: a review

Pediatric Research, Journal Year: 2018, Volume and Issue: 85(2), P. 234 - 241

Published: Oct. 8, 2018

Language: Английский

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Sensing strategy based on Carbon Quantum Dots obtained from riboflavin for the identification of pesticides

Sensors and Actuators B Chemical, Journal Year: 2019, Volume and Issue: 301, P. 127149 - 127149

Published: Sept. 16, 2019

Language: Английский

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Long-term exposure to ambient air pollution and autism spectrum disorder in children: A case-control study in Tehran, Iran

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 643, P. 1216 - 1222

Published: July 4, 2018

Language: Английский

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Environmental Chemicals and Autism: A Scoping Review of the Human and Animal Research

Environmental Health Perspectives, Journal Year: 2019, Volume and Issue: 127(4)

Published: April 1, 2019

Background: Estimates of autism prevalence have increased dramatically over the past two decades. Evidence suggests environmental factors may contribute to etiology disorder. Objectives: This scoping review aimed identify and categorize primary research reviews on association between prenatal early postnatal exposure chemicals development in epidemiological studies rodent models autism. Methods: PubMed was searched through 8 February 2018. Included assessed prior 2 months age humans or 14 d rodents. Rodent were considered relevant if they included at least one measurement reciprocal social communicative behavior repetitive stereotyped behavior. Study details are presented interactive displays using Tableau Public. Results: The search returned 21,603 unique studies, which 54 46 experimental 50 deemed relevant, covering 152 chemical exposures. most frequently studied exposures particulate matter (n=14), mercury nonspecific air pollution (n=10), lead (n=10). In chlorpyrifos (n=9), (n=6), (n=4). Discussion: Although is growing rapidly, wide variability exists study design conduct, investigated, outcomes assessed. Conclusions focus recommendations guide best practices epidemiology toxicology, including greater harmonization across these fields more quickly efficiently concern. particular, we recommend chlorpyrifos, lead, polychlorinated biphenyls (PCBs) be systematically reviewed order assess their relationship with There a pressing need move forward understand influences answer current regulatory questions inform treatment prevention efforts. https://doi.org/10.1289/EHP4386

Language: Английский

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