Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist)

Brain, Journal Year: 2020, Volume and Issue: 143(6), P. 1674 - 1685

Published: Jan. 17, 2020

Abstract Neurofeedback has begun to attract the attention and scrutiny of scientific medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims improve reporting experimental design standards in field.

Language: Английский

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The Potential of Functional Near-Infrared Spectroscopy-Based Neurofeedback—A Systematic Review and Recommendations for Best Practice

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: July 21, 2020

Background: The effects of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI)-neurofeedback on brain activation behaviors have been studied extensively in the past. More recently, researchers begun to investigate near-infrared spectroscopy-based neurofeedback (fNIRS-neurofeedback). FNIRS is a neuroimaging technique based hemodynamics, which easy use, portable, inexpensive, has reduced sensitivity movement artifacts. Method: We provide first systematic review database fNIRS-neurofeedback studies, synthesizing findings from 22 peer-reviewed studies (including total N = 441 participants; 337 healthy, 104 patients). (1) give comprehensive overview how training protocols were implemented, (2) online signal-processing methods used, (3) evaluate quality using pre-set methodological reporting criteria also present statistical sensitivity/power analyses, (4) effectiveness modulating activation, (5) its changing behavior healthy pathological populations. Results discussion: (1-2) Published are heterogeneous (e.g., targets, investigated populations, applied protocols, methods). Large randomized controlled trials still lacking. In view novelty field, published moderate. identified room for improvement important information power detect realistic effects. Several show that people can regulate hemodynamic signals cortical regions with these indicate feasibility motor control prefrontal functioning participants ameliorating symptoms clinical populations (stroke, ADHD, autism, social anxiety). However, valid conclusions about specificity or potential utility premature. Conclusion: Due advantages practicability relatively low cost, might suitable powerful alternative EEG fMRI great translation neurofeedback. Together more rigorous research practices, further improvements may lead solid understanding fNIRS-neurofeedback. Future will benefit exploiting fNIRS, offers unique opportunities research.

Language: Английский

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Current progress in real-time functional magnetic resonance-based neurofeedback: Methodological challenges and achievements

NeuroImage, Journal Year: 2019, Volume and Issue: 202, P. 116107 - 116107

Published: Aug. 19, 2019

Language: Английский

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Neurofeedback and Attention-Deficit/Hyperactivity-Disorder (ADHD) in Children: Rating the Evidence and Proposed Guidelines

Applied Psychophysiology and Biofeedback, Journal Year: 2020, Volume and Issue: 45(2), P. 39 - 48

Published: March 23, 2020

Abstract Stimulant medication and behaviour therapy are the most often applied accepted treatments for Attention-Deficit/Hyperactivity-Disorder (ADHD). Here we explore where non-pharmacological clinical intervention known as neurofeedback (NFB), fits on continuum of empirically supported treatments, using standard protocols. In this quantitative review utilized an updated stricter version APA guidelines rating ‘well-established’ focused efficacy effectiveness effect-sizes (ES) remission, with a focus long-term effects. Efficacy compared to benchmark studies. Only recent systematic reviews meta-analyses well multi-centre randomized controlled trials (RCT’s) will be included. Two confirmed significant protocols parent teacher rated symptoms medium effect size, sustained effects after 6–12 months. Four multicenter RCT’s demonstrated superiority semi-active control groups, medium-large sizes end treatment or follow-up remission rates 32–47%. Effectiveness in open-label studies was confirmed, no signs publication bias were found neurofeedback-specific side have been reported. Standard ADHD can concluded well-established large 32–47% assessed

Language: Английский

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Neurofeedback training in major depressive disorder: A systematic review of clinical efficacy, study quality and reporting practices

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 125, P. 33 - 56

Published: Feb. 15, 2021

Language: Английский

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Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Feb. 16, 2022

Abstract Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the circuit relevant an individual patient’s subset of might more precisely and thus effectively aid in alleviation their specific symptoms. We tested this hypothesis a proof-of-concept study using fMRI functional connectivity neurofeedback. targeted between left dorsolateral prefrontal cortex/middle frontal gyrus precuneus/posterior cingulate cortex, connection has been well-established as relating depressive Specifically, shown data-driven manner be less anticorrelated melancholic depression than healthy controls. Furthermore, posterior dominant state—which results loss anticorrelation—is expected specifically relate increase rumination such brooding. In line predictions, we found that, neurofeedback training, participant normalized (restored anticorrelation), related (depressive brooding symptoms), but not unrelated (trait anxiety), were reduced. Because these look promising, paradigm next needs examined greater sample size better Nonetheless, here provide preliminary evidence for correlation normalization network reduction Showing reproducibility, two experiments took place several years apart by different experimenters. Indicative its potential clinical utility, effects remained one-two months later. Clinical trial registration : Both reported registered trials (UMIN000015249, jRCTs052180169).

Language: Английский

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Reducing default mode network connectivity with mindfulness-based fMRI neurofeedback: a pilot study among adolescents with affective disorder history

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2540 - 2548

Published: March 30, 2023

Abstract Adolescents experience alarmingly high rates of major depressive disorder (MDD), however, gold-standard treatments are only effective for ~50% youth. Accordingly, there is a critical need to develop novel interventions, particularly ones that target neural mechanisms believed potentiate symptoms. Directly addressing this gap, we developed mindfulness-based fMRI neurofeedback (mbNF) adolescents aims reduce default mode network (DMN) hyperconnectivity, which has been implicated in the onset and maintenance MDD. In proof-of-concept study, ( n = 9) with lifetime history depression and/or anxiety were administered clinical interviews self-report questionnaires, each participant’s DMN central executive (CEN) personalized using resting state localizer. After localizer scan, completed brief mindfulness training followed by mbNF session scanner wherein they instructed volitionally relative CEN activation practicing meditation. Several promising findings emerged. First, successfully engaged brain during neurofeedback; participants spent more time lower than activation. Second, nine adolescents, led significantly reduced within-DMN connectivity, correlated post-mbNF increases mindfulness. Last, reduction connectivity mediated association between better performance increased These demonstrate can effectively non-invasively modulate intrinsic networks associated emergence persistence symptoms adolescence.

Language: Английский

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Homeostatic normalization of alpha brain rhythms within the default-mode network and reduced symptoms in PTSD following a randomized controlled trial of EEG neurofeedback

Brain Communications, Journal Year: 2023, Volume and Issue: 5(2)

Published: March 2, 2023

Collective research has identified a key electroencephalogram signature in patients with post-traumatic stress disorder, consisting of abnormally reduced alpha (8-12 Hz) rhythms. We conducted 20-session, double-blind, randomized controlled trial desynchronizing neurofeedback disorder over 20 weeks. Our objective was to provide mechanistic evidence underlying potential clinical improvements by examining changes aberrant brain rhythms (namely, oscillations) as function treatment. randomly assigned participants primary diagnosis (n = 38) either an experimental group 20) or sham-control 18). A multichannel cap used record whole-scalp resting-state activity pre- and post-neurofeedback treatment, for both the groups. first observed significantly relative source power at baseline compared age/sex-matched neurotypical healthy controls 32), primarily within regions anterior default mode network. Post-treatment, we found that only demonstrated significant resynchronization areas displayed low baseline. In parallel, decreased severity scores only, when comparing post-treatment (Cohen's d 0.77) three-month follow-up 0.75), remission rate 60.0% follow-up. Overall, our results indicate training can rescue pathologically rhythmicity, functional biomarker repeatedly been linked symptoms hyperarousal cortical disinhibition disorder. This provides long-term suggesting 'alpha rebound effect' (i.e. homeostatic resynchronization) occurs network previously implicated

Language: Английский

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Real-time fMRI neurofeedback reduces default mode network and auditory cortex functional connectivity in schizophrenia

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

ABSTRACT Background and Hypothesis Auditory verbal hallucinations (AHs) are a cardinal symptom of schizophrenia that can cause distress but not always responsive to antipsychotic medications. There is critical need develop novel interventions target neural mechanisms underlying AHs. We developed real-time fMRI neurofeedback (NFB) paradigm for AHs aims at modulating default mode network (DMN) functional connectivity. Study Design Patients with or schizoaffective disorders who were experiencing ( N = 25) attempted decrease brain activation while listening sentences recorded in another person’s voice increase their own voice. Participants randomly assigned the ‘real’ group n 12) received based on signals from auditory cortex superior temporal gyrus (STG) those ‘sham’ 13) motor signals. Results Analyzing resting state data collected pre- post-NFB, we found that: (1) baseline, stronger within-DMN connectivity between medial prefrontal (MPFC) posterior cingulate was associated higher severity; (2) after NFB, participants real group, compared sham showed greater reduction MPFC cortices STG middle (MTG). Notably, MPFC-STG/MTG all group. Conclusions These findings suggest NFB effectively non-invasively modulate regions psychosis.

Language: Английский

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Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

We have reported previously a reduction in superior temporal gyrus (STG) activation and auditory verbal hallucinations (AHs) after real-time fMRI neurofeedback (NFB) schizophrenia patients with AHs. With this randomized, participant-blinded, sham-controlled trial, we expanded our previous results. Specifically, examined effects from the STG, an area associated hallucinations. The were compared to Sham-NFB motor cortex, region unrelated Twenty-three adults or schizoaffective disorder frequent medication-resistant performed mindfulness meditation ignore pre-recorded stranger's voices while receiving either STG (n=10, Real-NFB) cortex (n=13 Sham-NFB). Individuals randomized received Real-NFB subsequent visit, providing within-subject 'Real-after-Sham-NFB' comparison. Both groups showed reduced AHs NFB, no group differences. Compared group, more secondary (AC) connectivity between AC cognitive control regions including dorsolateral prefrontal (DLPFC) anterior cingulate. was also observed Real-after-Sham-NFB condition. Secondary AC-DLPFC correlated hallucination group. Replicating prior results, both primary activation, suggesting may regulate bottom-up processes involved Our findings emphasize delivering NFB brain They provide insights into network interactions, highlighting complex processing dynamics top-down modulation of sensory information.

Language: Английский

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