Alzheimer Mechanisms and Therapeutic Strategies

Cell, Journal Year: 2012, Volume and Issue: 148(6), P. 1204 - 1222

Published: March 1, 2012

Language: Английский

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Molecular Mechanisms of Fear Learning and Memory

Cell, Journal Year: 2011, Volume and Issue: 147(3), P. 509 - 524

Published: Oct. 1, 2011

Language: Английский

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Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders

The American Journal of Human Genetics, Journal Year: 2014, Volume and Issue: 94(5), P. 677 - 694

Published: April 24, 2014

Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed excess genic deletions duplications in affected versus control groups (1.41-fold, p = 1.0 × 10(-5)) increase subjects carrying exonic pathogenic CNVs overlapping known loci associated with dominant or X-linked ASD intellectual disability (odds ratio 12.62, 2.7 10(-15), ∼3% subjects). Pathogenic CNVs, often showing variable expressivity, included rare de novo inherited events at 36 loci, implicating ASD-associated genes (CHD2, HDAC4, GDI1) previously linked to other neurodevelopmental disorders, as well such SETD5, MIR137, HDAC9. Consistent hypothesized gender-specific modulators, females were more likely have highly penetrant (p 0.017) also overrepresented among fragile X syndrome protein targets 0.02). Genes by and/or loss-of-function single-nucleotide variants converged on networks related neuronal signaling development, synapse function, chromatin regulation.

Language: Английский

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The Restless Engram: Consolidations Never End

Annual Review of Neuroscience, Journal Year: 2012, Volume and Issue: 35(1), P. 227 - 247

Published: May 20, 2012

Memory consolidation is the hypothetical process in which an item memory transformed into a long-term form. It commonly addressed at two complementary levels of description and analysis: cellular/synaptic level (synaptic consolidation) brain systems (systems consolidation). This article focuses on selected recent advances research, including reconsolidation items, mechanisms transformation content cue-dependency items over time, as well role rest sleep consolidating shaping memories. Taken together, picture that emerges dynamic engrams are formed, modified, remodified time by using synaptic subroutines. implies that, contrary to interpretations have dominated neuroscience for while, but similar long-standing cognitive concepts, least some may never really come end.

Language: Английский

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The synaptic plasticity and memory hypothesis: encoding, storage and persistence

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2013, Volume and Issue: 369(1633), P. 20130288 - 20130288

Published: Dec. 3, 2013

The synaptic plasticity and memory hypothesis asserts that activity-dependent is induced at appropriate synapses during formation both necessary sufficient for the encoding trace storage of type mediated by brain area in which it observed. Criteria establishing necessity sufficiency such mediating have been identified are here reviewed relation to new work using some diverse techniques contemporary neuroscience. Evidence derived optical imaging, molecular-genetic optogenetic conjunction with behavioural analyses continues offer support idea changing strength connections between neurons one major mechanisms engrams stored brain.

Language: Английский

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Finding the engram

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(9), P. 521 - 534

Published: Aug. 20, 2015

Language: Английский

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Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

Genes Brain & Behavior, Journal Year: 2013, Volume and Issue: 13(1), P. 69 - 86

Published: Nov. 28, 2013

To date, there is rapidly increasing evidence for host-microbe interaction at virtually all levels of complexity, ranging from direct cell-to-cell communication to extensive systemic signalling, and involving various organs organ systems, including the central nervous system. As such, discovery that differential microbial composition associated with alterations in behaviour cognition has significantly contributed establishing microbiota-gut-brain axis as an extension well-accepted gut-brain concept. Many efforts have been focused on delineating a role this health disease, stress-related disorders such depression, anxiety irritable bowel syndrome neurodevelopmental autism. There also growing appreciation epigenetic mechanisms shaping brain behaviour. However, epigenetics informing interactions received little attention date. This despite fact are many plausible routes between host-microbiota dialogue. From new perspective we put forward novel, yet testable, hypotheses. Firstly, suggest gut-microbial products can affect chromatin plasticity within their host's turn leads changes neuronal transcription eventually alters host Secondly, argue microbiota important mediator gene-environment interactions. Finally, reason itself may be viewed entity. In conclusion, fields (neuro)epigenetics microbiology converging more interdisciplinary studies necessary unravel full range interaction.

Language: Английский

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From neural development to cognition: unexpected roles for chromatin

Nature Reviews Genetics, Journal Year: 2013, Volume and Issue: 14(5), P. 347 - 359

Published: April 9, 2013

Language: Английский

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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Nature Neuroscience, Journal Year: 2013, Volume and Issue: 16(5), P. 613 - 621

Published: March 22, 2013

Language: Английский

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Epigenetic mechanisms in neurological disease

Nature Medicine, Journal Year: 2012, Volume and Issue: 18(8), P. 1194 - 1204

Published: Aug. 1, 2012

Language: Английский

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