Peptides,
Journal Year:
2016,
Volume and Issue:
80, P. 96 - 107
Published: Feb. 19, 2016
Malpighian
tubules
are
critical
organs
for
epithelial
fluid
transport
and
stress
tolerance
in
insects,
under
neuroendocrine
control
by
multiple
neuropeptides
secreted
identified
neurons.
Here,
we
demonstrate
roles
CRF-like
diuretic
hormone
44
(DH44)
Drosophila
melanogaster
kinin
(Drome-kinin,
DK)
desiccation
starvation
tolerance.
Gene
expression
labelled
DH44
ligand
binding
data,
as
well
highly
selective
knockdowns
and/or
neuronal
ablations
of
neurons
the
pars
intercerebralis
receptor
(DH44-R2)
tubule
principal
cells,
indicate
that
suppression
signalling
improves
intact
fly.
Drome-kinin
receptor,
encoded
leucokinin
gene,
LKR,
is
expressed
stellate
cells
tubules.
LKR
knockdown
DH44-expressing
reduces
tubule-specific
suggesting
interactions
between
LK
pathways.
Finally,
although
a
role
DK
was
not
defined,
novel
cell-specific
Starvation
increases
gene
LKR.
Also,
significantly
reduced
tolerance,
demonstrating
neuropeptide
during
stress.
Proceedings of the National Academy of Sciences,
Journal Year:
2013,
Volume and Issue:
110(22)
Published: May 13, 2013
Significance
Peptides
and
their
specific
receptors
form
molecular
peptidergic
systems
(PSs)
that
are
essential
components
of
neuronal
communication
in
the
animal
brain.
Many
PSs
have
been
characterized
insects
mammals
but
precise
evolutionary
relationship
is
not
fully
understood.
We
interrogated
genomic
sequence
databases
used
phylogenetic
reconstruction
tools
to
show
a
large
fraction
human
were
already
present
last
common
ancestor
flies,
mollusks,
urchins,
mammals.
Our
analysis
provides
comprehensive
view
will
pave
way
for
comparative
studies
leading
better
understanding
physiology
behavior.
Annual Review of Neuroscience,
Journal Year:
2014,
Volume and Issue:
37(1), P. 329 - 346
Published: July 8, 2014
Neuromodulation
underlies
many
behavioral
states
and
has
been
extensively
studied
in
small
circuits.
This
allowed
the
systematic
exploration
of
how
neuromodulatory
substances
neurons
that
release
them
can
influence
circuit
function.
The
physiological
state
a
network
its
level
activity
have
profound
effects
on
modulators
act,
phenomenon
known
as
dependence.
We
provide
insights
from
experiments
computational
work
show
dependence
arise
consequences
it
for
cellular
These
observations
pose
general
unsolved
question
is
relevant
to
all
nervous
systems:
How
robust
modulation
achieved
spite
animal-to-animal
variability
degenerate,
nonlinear
mechanisms
production
neuronal
activity?
