The corticotropin-releasing factor-like diuretic hormone 44 (DH 44 ) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster DOI Creative Commons

Elizabeth Cannell,

Anthony J. Dornan, Kenneth A. Halberg

et al.

Peptides, Journal Year: 2016, Volume and Issue: 80, P. 96 - 107

Published: Feb. 19, 2016

Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, under neuroendocrine control by multiple neuropeptides secreted identified neurons. Here, we demonstrate roles CRF-like diuretic hormone 44 (DH44) Drosophila melanogaster kinin (Drome-kinin, DK) desiccation starvation tolerance. Gene expression labelled DH44 ligand binding data, as well highly selective knockdowns and/or neuronal ablations of neurons the pars intercerebralis receptor (DH44-R2) tubule principal cells, indicate that suppression signalling improves intact fly. Drome-kinin receptor, encoded leucokinin gene, LKR, is expressed stellate cells tubules. LKR knockdown DH44-expressing reduces tubule-specific suggesting interactions between LK pathways. Finally, although a role DK was not defined, novel cell-specific Starvation increases gene LKR. Also, significantly reduced tolerance, demonstrating neuropeptide during stress.

Language: Английский

Suppression of Insulin Production and Secretion by a Decretin Hormone DOI Creative Commons

Ronald W. Alfa,

Sangbin Park, Kaman Lee

et al.

Cell Metabolism, Journal Year: 2015, Volume and Issue: 21(2), P. 323 - 334

Published: Feb. 1, 2015

Language: Английский

Citations

131
Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off DOI Creative Commons
Verónica María Corrales-Carvajal, A. Aldo Faisal, Carlos Ribeiro

et al.

eLife, Journal Year: 2016, Volume and Issue: 5

Published: Oct. 22, 2016

Internal states can profoundly alter the behavior of animals. A quantitative understanding behavioral changes upon metabolic challenges is key to a mechanistic dissection how animals maintain nutritional homeostasis. We used an automated video tracking setup characterize amino acid and reproductive interact shape exploitation exploration decisions taken by adult Drosophila melanogaster. find that these two have specific effects on stop at leave proteinaceous food patches. Furthermore, internal nutrient state defines exploration-exploitation trade-off: nutrient-deprived flies focus patches while satiated explore more globally. Finally, we show olfaction mediates efficient recognition yeast as appropriate protein source in mated females octopamine specifically required mediate homeostatic postmating responses without affecting sensing. therefore modulate aspects change selection.

Language: Английский

Citations

126
Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior DOI
Chun Hu, Meike Petersen, Nina Hoyer

et al.

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(8), P. 1085 - 1095

Published: June 12, 2017

Language: Английский

Citations

122
Call it Worm Sleep DOI
Nicholas F. Trojanowski, David M. Raizen

Trends in Neurosciences, Journal Year: 2015, Volume and Issue: 39(2), P. 54 - 62

Published: Dec. 30, 2015

Language: Английский

Citations

121
The corticotropin-releasing factor-like diuretic hormone 44 (DH 44 ) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster DOI Creative Commons

Elizabeth Cannell,

Anthony J. Dornan, Kenneth A. Halberg

et al.

Peptides, Journal Year: 2016, Volume and Issue: 80, P. 96 - 107

Published: Feb. 19, 2016

Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, under neuroendocrine control by multiple neuropeptides secreted identified neurons. Here, we demonstrate roles CRF-like diuretic hormone 44 (DH44) Drosophila melanogaster kinin (Drome-kinin, DK) desiccation starvation tolerance. Gene expression labelled DH44 ligand binding data, as well highly selective knockdowns and/or neuronal ablations of neurons the pars intercerebralis receptor (DH44-R2) tubule principal cells, indicate that suppression signalling improves intact fly. Drome-kinin receptor, encoded leucokinin gene, LKR, is expressed stellate cells tubules. LKR knockdown DH44-expressing reduces tubule-specific suggesting interactions between LK pathways. Finally, although a role DK was not defined, novel cell-specific Starvation increases gene LKR. Also, significantly reduced tolerance, demonstrating neuropeptide during stress.

Language: Английский

Citations

117