Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

Nature Genetics, Journal Year: 2021, Volume and Issue: 53(2), P. 174 - 184

Published: Jan. 28, 2021

Language: Английский

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Recurrent architecture for adaptive regulation of learning in the insect brain

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(4), P. 544 - 555

Published: March 23, 2020

Language: Английский

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Memory editing from science fiction to clinical practice

Nature, Journal Year: 2019, Volume and Issue: 572(7767), P. 43 - 50

Published: July 31, 2019

Language: Английский

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A meta-analysis of conditioned fear generalization in anxiety-related disorders

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 47(9), P. 1652 - 1661

Published: April 30, 2022

Language: Английский

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Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Responding appropriately to potential threats before they materialize is critical avoiding disastrous outcomes. Here we examine how threat-coping behavior regulated by the tail of striatum (TS) and its dopamine input. Mice were presented with a threat (a moving object) while pursuing rewards. Initially, mice failed obtain rewards but gradually improved in later trials. We found that TS promoted avoidance threat, even at expense reward acquisition. Furthermore, activity D1 receptor-expressing neurons prediction. In contrast, D2 suppressed facilitated overcoming threat. Dopamine axon activation not only potentiated responses novel sensory stimuli also boosted them acutely. These results demonstrate an opponent interaction TS, modulated dopamine, dynamically regulates threats. During foraging threat–reward conflicts mice, modulates two competing neuron types for flexible coping, from initial eventual

Language: Английский

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The computational nature of memory modification

eLife, Journal Year: 2017, Volume and Issue: 6

Published: March 15, 2017

Retrieving a memory can modify its influence on subsequent behavior. We develop computational theory of modification, according to which modification trace occurs through classical associative learning, but is eligible for depends structure learning mechanism that discovers the units association by segmenting stream experience into statistically distinct clusters (latent causes). New memories are formed when infers new latent cause underlies current sensory observations. By same token, old modified and observations inferred have been generated cause. derive this framework from probabilistic principles, present implementation. Simulations demonstrate our model reproduce major experimental findings studies in Pavlovian conditioning literature.

Language: Английский

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Re-evaluation of learned information in Drosophila

Nature, Journal Year: 2017, Volume and Issue: 544(7649), P. 240 - 244

Published: April 1, 2017

Language: Английский

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Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Oct. 24, 2018

Abstract The thalamic nucleus reuniens (RE) receives dense projections from the medial prefrontal cortex (mPFC), interconnects mPFC and hippocampus, may serve a pivotal role in regulating emotional learning memory. Here we show that RE its afferents are critical for extinction of Pavlovian fear memories rats. Pharmacological inactivation during or retrieval increases freezing to an extinguished conditioned stimulus (CS); renewal outside context was unaffected. Suppression is associated with increase c-fos expression spike firing neurons CS. suppressing requires mPFC, insofar as pharmacogenetically silencing impairs These results reveal mPFC-RE circuits inhibit fear, function essential adaptive regulation.

Language: Английский

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Chemogenetic Activation of an Extinction Neural Circuit Reduces Cue-Induced Reinstatement of Cocaine Seeking

Journal of Neuroscience, Journal Year: 2016, Volume and Issue: 36(39), P. 10174 - 10180

Published: Sept. 28, 2016

The ventromedial prefrontal cortex (vmPFC) has been shown to negatively regulate cocaine-seeking behavior, but the precise conditions by which vmPFC activity can be exploited reduce cocaine relapse are currently unknown. We used viral-mediated gene transfer of designer receptors (DREADDs) activate neurons and examine consequences on seeking in a rat self-administration model relapse. Activation with Gq-DREADD reduced reinstatement elicited cocaine-associated cues, not itself. retro-DREADD approach confine that project medial nucleus accumbens shell, confirming these responsible for decreased cue-induced seeking. effects activation depended prior extinction training, consistent reported role this structure memory. These data help define under chemogenetic neural circuits triggered reminder cues.The projection shell is important seeking, its anatomical proximity relapse-promoting from dorsomedial core makes it difficult selectively enhance neuronal one pathway or other using traditional pharmacotherapy (e.g., systemically administered drugs). Viral-mediated delivery an activating and/or projections allows exploitation circuit was particularly effective against cues.

Language: Английский

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Measuring learning in human classical threat conditioning: Translational, cognitive and methodological considerations

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 114, P. 96 - 112

Published: April 27, 2020

Language: Английский

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