Development and Functional Diversification of Cortical Interneurons

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 294 - 313

Published: Oct. 1, 2018

Language: Английский

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Genetic and activity-dependent mechanisms underlying interneuron diversity

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(5), P. 299 - 309

Published: April 6, 2017

Language: Английский

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Thalamocortical Circuit Motifs: A General Framework

Neuron, Journal Year: 2019, Volume and Issue: 103(5), P. 762 - 770

Published: Sept. 1, 2019

Language: Английский

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Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Biological Psychiatry, Journal Year: 2017, Volume and Issue: 81(10), P. 848 - 861

Published: March 15, 2017

Language: Английский

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Opposing Effects on Na V 1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures

Biological Psychiatry, Journal Year: 2017, Volume and Issue: 82(3), P. 224 - 232

Published: Jan. 27, 2017

Variants in the SCN2A gene that disrupt encoded neuronal sodium channel NaV1.2 are important risk factors for autism spectrum disorder (ASD), developmental delay, and infantile seizures. observed seizures predominantly missense, leading to a gain of function increased excitability. How variants associated with ASD affect excitability unclear.We examined properties 11 ASD-associated heterologous expression systems using whole-cell voltage-clamp electrophysiology immunohistochemistry. Resultant data were incorporated into computational models developing mature cortical pyramidal cells express NaV1.2.In contrast contribute seizure, we found all dampened or eliminated function. Incorporating these electrophysiological results compartmental model excitatory neurons demonstrated variants, regardless their mechanism action, resulted deficits Corresponding analysis predicted minimal change excitability.This functional characterization thus identifies mutation dysfunction as most frequently factor detectable by exome sequencing suggests changes excitability, particularly neurons, may etiology.

Language: Английский

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Transient cortical circuits match spontaneous and sensory-driven activity during development

Science, Journal Year: 2020, Volume and Issue: 370(6514)

Published: Oct. 16, 2020

At the earliest developmental stages, spontaneous activity synchronizes local and large-scale cortical networks. These networks form functional template for establishment of global thalamocortical architecture. The connections are established autonomously. However, from sensory periphery reshapes these circuits as soon afferents reach cortex. early-generated, largely transient neurons subplate play a key role in integrating sensory-driven activity. Early pathological conditions-such hypoxia, inflammation, or exposure to pharmacological compounds-alter patterns, which subsequently induce disturbances network This dysfunction may lead miswiring and, at later can be associated with neurological psychiatric conditions.

Language: Английский

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Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits

Trends in Neurosciences, Journal Year: 2018, Volume and Issue: 41(10), P. 689 - 700

Published: Sept. 25, 2018

Language: Английский

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Interneuron Types as Attractors and Controllers

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 43(1), P. 1 - 30

Published: July 12, 2019

Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role cortical processing. Here, we revisit the question of how codify diversity based upon division labor function as controllers information flow. suggest developmental trajectories provide a guide for appreciating argue subtype identity is generated using configurational (rather than combinatorial) code transcription factors produce attractor states underlying gene regulatory network. present our updated three-stage model specification: an initial cardinal step, allocating into few major classes, followed definitive refinement, creating subclasses settling within cortex, lastly, state determination, reflecting incorporation functional circuit ensembles. close discussing findings indicating classes are both evolutionarily ancient conserved. propose complexity circuits phylogenetically old types, complemented evolutionary increase principal neuron diversity. This suggests natural neurobiological definition might derived from match between origin computational function.

Language: Английский

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Circuitry Underlying Experience-Dependent Plasticity in the Mouse Visual System

Neuron, Journal Year: 2020, Volume and Issue: 106(1), P. 21 - 36

Published: April 1, 2020

Since the discovery of ocular dominance plasticity, neuroscientists have understood that changes in visual experience during a discrete developmental time, critical period, trigger robust cortex. State-of-the-art tools used to probe connectivity with cell-type-specific resolution expanded understanding circuit underlying experience-dependent plasticity. Here, we review circuitry mouse, describing projections from retina thalamus, between thalamus and cortex, within We discuss how development leads precise identify synaptic loci, which can be altered by activity or experience. Plasticity extends features beyond dominance, involving subcortical cortical regions, connections inhibitory interneurons. Experience-dependent plasticity contributes alignment networks spanning Disruption this may underlie aberrant sensory processing some neurodevelopmental disorders. Vision is so inseparable our conception world "seeing believing." Sight crucial recognize friends, find savory food, plan movement. While aspects system form utero, circuits significant spontaneous activity- reorganization early life. Developmental refinement perturbations small errors, imparting uniqueness based on without an exhaustive molecular code specifying each connection. occur at specific time points. The best-known sensitive periods (SPs) (CPs). SPs are windows when neuronal exhibit modification. Such easily evoked greater magnitude SP, but smaller extent other ages. CPs subset SPs, distinguished strict temporal onset closure fact period required for subsequent normal function (Voss, 2013Voss P. Sensitive deprivation.Front. Psychol. 2013; 4: 664Crossref PubMed Scopus (25) Google Scholar). This change not reversible except CP. CP was described Hubel Wiesel. In binocular responsiveness input deprived eye attenuated weeks monocular deprivation (MD). (OD), called (ODP), only occurs development. Moreover, include reduction acuity eye, amblyopia. ODP reversed CP, recovery possible once closes. Growing evidence suggests entirely extinguished closure. Substantial adult outside activated, often stimulus paradigms distinct those effective (Espinosa Stryker, 2012Espinosa J.S. Stryker M.P. Development primary cortex.Neuron. 2012; 75: 230-249Abstract Full Text PDF (294) Scholar, Fong et al., 2016Fong M.F. Mitchell D.E. Duffy K.R. Bear Rapid effects enabled temporary inactivation retinas.Proc Natl Acad Sci U S A. 2016; 113: 14139-14144Crossref (14) Hensch Quinlan, 2018Hensch T.K. Quinlan E.M. Critical amblyopia.Vis. Neurosci. 2018; 35: E014PubMed Sato 2008Sato M. Distinctive plasticity.J. 2008; 28: 10278-10286Crossref (153) Thus, perhaps more accurately defined as occurring SP. ambiguity highlights difficulty distinguishing especially monitor developed. Different loci along pathway vary their sensitivity (Kang 2013Kang E. Durand S. LeBlanc J.J. Chen C. Fagiolini Visual absence experience.J. 33: 17789-17796Crossref (42) Scholar), one synapse enduring effect overall because its influence downstream synapses irreversibly. Homeostatic responses also activated compensate synapse, another (Whitt 2014Whitt J.L. Petrus Lee H.K. homeostatic neocortex.Neuropharmacology. 2014; 78: 45-54Crossref (39) end, indelibly Therefore, purpose review, define window there response followed clear diminishing same stimuli. Wiesel, has served model studying Changes following MD measured comparing (by single unit recordings, [VEPs], vivo imaging) stimulation eye. These straightforward measurements made canonical experimental system. More recently, enabling measurement such orientation preference suggest many show occasionally different rules. implies traditionally circuitry, thalamic relay cells, developmentally regulated unrelated OD shifts. Considerable effort been devoted basis (Fagiolini 2004Fagiolini Fritschy J.M. Löw K. Möhler H. Rudolph U. Specific GABAA plasticity.Science. 2004; 303: 1681-1683Crossref (332) means label, monitor, manipulate these components independently understand basic where results changes. mouse powerful model. Despite zone lower 1994Fagiolini Pizzorusso T. Berardi N. Domenici L. Maffei Functional postnatal rat cortex role experience: dark rearing deprivation.Vision Res. 1994; 34: 709-720Crossref (491) mice similar primates cats. clearly day 19 (P19) P32 (Gordon 1996Gordon J.A. mouse.J. 1996; 16: 3274-3286Crossref Mice offer possibility genetic access neuron populations ODP, including subsets excitatory (Gerfen 2013Gerfen C.R. Paletzki R. Heintz GENSAT BAC cre-recombinase driver lines study functional organization cerebral basal ganglia circuits.Neuron. 80: 1368-1383Abstract (242) Scholar) neurons (Taniguchi 2011Taniguchi He Wu Kim Paik Sugino Kvitsiani D. Fu Y. Lu J. Lin al.A resource Cre targeting GABAergic 2011; 71: 995-1013Abstract (822) approaches allow targeted recording, optical manipulation (Madisen 2012Madisen Mao Koch Zhuo Berenyi Fujisawa Hsu Y.W. Garcia 3rd, A.J. Gu X. Zanella toolbox Cre-dependent optogenetic transgenic light-induced activation silencing.Nat. 15: 793-802Crossref (616) calcium indicators (Chen 2013Chen T.W. Wardill T.J. Sun Pulver S.R. Renninger S.L. Baohan Schreiter E.R. Kerr R.A. Orger M.B. Jayaraman V. al.Ultrasensitive fluorescent proteins imaging activity.Nature. 499: 295-300Crossref (2349) advances focusing across species, mechanisms reviewed elsewhere (Hensch Kiorpes, 2015Kiorpes primates: neural periods.Dev. Neurobiol. 2015; 1080-1090Crossref refer work areas, extrapolating Studies revealed apply than simply OD. With variety manipulations quantifying receptive field (RF) properties, orientation, luminance, spatial frequency tuning, findings rules differ ODP. studies demonstrate To instantiated, detailed map needed, long-range major brain structures (Figures 1 2) cell types 3 4). true neocortex, contains types, organized layers, multiple per layer. A near-complete census (Sugino 2019Sugino Clark Schulmann Shima Wang Hunt D.L. Hooks B.M. Tränkner Chandrashekar Picard al.Mapping transcriptional diversity genetically anatomically brain.eLife. 2019; 8: e38619Crossref (3) Tasic 2018Tasic B. Yao Z. Graybuck L.T. Smith K.A. Nguyen T.N. Bertagnolli Goldy Garren Economo M.N. Viswanathan al.Shared transcriptomic neocortical areas.Nature. 563: 72-78Crossref (167) promises full range subtypes. provides parts list local circuit. Given profoundly plasticity? Our aim place order context, assessing whether hierarchy earlier way nodes thalamocortical (TC) afferents compared intracortical L4 L2/3.Figure 2Thalamocortical OrganizationShow caption(A) includes dorsal ventral subdivisions (dLGN vLGN, blue purple). Core shell areas dLGN receive inputs RGC types. Higher-order LP (red).(B) Thalamic axons V1 arborize laminae.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 3Inhibitory Excitatory Local Connectivity CortexShow Inhibitory interneurons laminar distribution 5-HT3AR+ concentrated L1 L2/3, VIP+ PV+ SST+ present all (after 2010Lee Hjerling-Leffler Zagha Fishell G. Rudy largest group superficial expresses ionotropic serotonin receptors.J. 2010; 30: 16796-16808Crossref (323) Xu 2010Xu Roby K.D. Callaway Immunochemical characterization neurons: three chemically classes cells.J. Comp. Neurol. 518: 389-404Crossref (256) Subtypes highlighted table right.(B) bipolar disinhibit specifically inhibiting neurons. cells tonically inhibit pyramidal (Pyr) apical dendrites. Tonic inhibition released become active (Pfeffer 2013Pfeffer C.K. Xue Huang Z.J. Scanziani Inhibition cortex: logic molecularly interneurons.Nat. 1068-1076Crossref (527) Input VIP (black magenta arrows) areas. L4, less abundant.(C D) Major granular supragranular given layer nearby layers (Xu 2016Xu Olivas N.D. Ikrar Peng Holmes T.C. Nie Q. Shi Primary shows laminar-specific balanced connectivity.J. Physiol. 594: 1891-1910Crossref Ascending (left) descending (right), thicknesses proportional connection strength. Laminae shown red. Strength illustration (C) matrix (D), pre- postsynaptic labeled.(E) L2/3 L4.View 4Developmental Cortical Near Period (CP)Show For illustrated. illustrated black. (blue), (burgundy), (green) color coded, neuromodulatory acetylcholine (purple). TC age annotated bottom. interneuron precede (Jiang 2010Jiang Sohya Sarihi Yanagawa Tsumoto Laminar-specific maturation transmission susceptibility related endocannabinoid cortex.J. 14261-14272Crossref (33) PV correlated matures (Cossell 2015Cossell Iacaruso Muir D.R. Houlton Sader E.N. Ko Hofer S.B. Mrsic-Flogel T.D. strength cortex.Nature. 399-403Crossref (191) 2013Ko Cossell Baragli Antolik Clopath emergence microcircuits 496: 96-100Crossref (198) neurons, initially strong, grows weaker loses cholinergic modulation (Yaeger 2019Yaeger C.E. Ringach Trachtenberg J.T. Neuromodulatory control localized dendritic spiking 567: 100-104Crossref Scholar).(B) Mature summarized.View (PPT) (A) (red). (B) laminae. right. abundant. (C labeled. (E) L4. summarized. mammals begins retina, retinal ganglion (RGC) target number superior colliculus (SC), lateral geniculate nucleus (dLGN), suprachiasmatic (SCN; Figures 1A–1C). Blue red figure illustrate corresponding ipsilateral contralateral eyes, eye-specific segregation dLGN. projection rounded patch surrounded larger area input. Some overlap exists (Figure 1B; Howarth 2014Howarth Walmsley Brown T.M. Binocular integration nuclei.Curr. Biol. 24: 1241-1247Abstract subdivided into core region, projecting principally 4 (L4) (V1, VISp reference atlas; Kuan 2015Kuan Li Lau Feng Bernard Sunkin S.M. Zeng Dang Hawrylycz Ng Neuroinformatics Allen Mouse Brain Atlas.Methods. 73: 4-17Crossref (72) largely targets (Cruz-Martín 2014Cruz-Martín El-Danaf R.N. Osakada F. Sriram Dhande O.S. P.L. Ghosh Huberman A.D. dedicated links direction-selective 507: 358-361Crossref (151) posterior (LP) (similar pulvinar primates), projects strongly L1, deeper L5A. structure output (Bennett 2019Bennett Gale S.D. Garrett M.E. Newton M.L. Murphy G.J. Olsen Higher-Order Circuits Channel Parallel Streams Information Mice.Neuron. 102: 477-492.e5Abstract (23) Two intrinsic interneurons, former outnumber latter ∼4:1. Intrinsic make dendrodendritic axodendritic onto (triads; Bickford 2010Bickford Slusarczyk Dilger E.K. Krahe T.E. Kucuk Guido W. Synaptic nucleus.J. 622-635Crossref (52) Morgan 2016Morgan Berger Wetzel A.W. Lichtman J.W. Fuzzy Logic Network Thalamus.Cell. 165: 192-206Abstract (88) Rafols Valverde, 1973Rafols Valverde mouse. Golgi electron microscopic study.J. 1973; 150: 303-332Crossref two corticothalamic (CT) well reticular (TRNs). project sending collaterals TRN. Interneurons parvalbumin positive (PV+), whereas PV−, although complete (Kalish 2018Kalish B.T. Cheadle Hrvatin Nagy M.A. Rivera Crow Gillis Kirchner Greenberg Single-cell transcriptomics developing reveals insights assembly refinement.Proc. Natl. Acad. Sci. USA. 115: E1051-E1060Crossref (17) CT inputs, turn, send TRNs. integrates, modifies, relays information passing V1. Experience-Dependent Thalamus. cat, much (Wiesel Hubel, 1963aWiesel D.H. striate kittens vision eye.J. Neurophysiol. 1963; 26: 1003-1017Crossref (1751) shrinkage somata dLGN, little (Sherman Spear, 1982Sherman Spear P.D. Organization pathways visually cats.Physiol. Rev. 1982; 62: 738-855Crossref (493) Wiesel 1963bWiesel Effects Deprivation Morphology Physiology Cells Cats Lateral Geniculate Body.J. 978-993Crossref (797) (Guzik-Kornacka 2016Guzik-Kornacka van der Bourg Vajda Joly Christ Schwab Pernet Nogo-A deletion increases optokinetic system.Brain Struct. Funct. 221: 317-329Crossref (10) led view predominantly phenomenon. contrast uncovered previously recognized. traditional divides territories, region. However, recordings dorsomedial responsive stimulation, indicating convergent both eyes (Howarth extend dendrites (Krahe 2011Krahe Henderson S.C. Morphologically regional preferences 31: 17437-17448Crossref (57) below (∼P18–P32) shifts relative depends receptor α1 subunit (Sommeijer 2017Sommeijer J.P. Ahmadlou Saiepour M.H. Seignette Min Heimel Levelt C.N. regulates critical-period thalamus.Nat. 2017; 20: 1715-1721Crossref (15) Future needed reveal potential onsets opening reversible. Notably, boutons terminating MD, even (Jaepel 2017Jaepel Hübener Bonhoeffer Rose mice.Nat. 1708-1714Crossref Bonhoeffe

Language: Английский

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Spontaneous activity in developing thalamic and cortical sensory networks

Neuron, Journal Year: 2021, Volume and Issue: 109(16), P. 2519 - 2534

Published: July 21, 2021

Language: Английский

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