γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor DOI Creative Commons
Lucas Restrepo, Alison T. DePew, Elizabeth R. Moese

et al.

Developmental Cell, Journal Year: 2022, Volume and Issue: 57(13), P. 1643 - 1660.e7

Published: June 1, 2022

Developing synapses mature through the recruitment of specific proteins that stabilize presynaptic and postsynaptic structure function. Wnt ligands signaling via Frizzled (Fz) receptors play many crucial roles in neuronal synaptic development, but whether how Fz influence maturation is incompletely understood. Here, we show Fz2 receptor cleavage γ-secretase complex required for development maturation. In absence γ-secretase, Drosophila neuromuscular fail to recruit scaffolding cytoskeletal proteins, leading behavioral deficits. Introducing presenilin mutations linked familial early-onset Alzheimer's disease into flies leads phenotypes are identical those seen null alleles. This conserved role highlights importance suggests processing by neurodegeneration may be a shared mechanism with aspects development.

Language: Английский

Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice DOI Creative Commons

Yohan S. S. Auguste,

Austin Ferro, Jessica A. Kahng

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(10), P. 1273 - 1278

Published: Sept. 28, 2022

Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited oligodendrogenesis. Here we show that contribute thalamocortical presynapse elimination in developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases response sensory experience during neural circuit refinement. Our data suggest may regulate synaptic connectivity brain independently

Language: Английский

Citations

103
Vision-dependent specification of cell types and function in the developing cortex DOI Creative Commons
Sarah Cheng, Salwan Butrus, Liming Tan

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(2), P. 311 - 327.e24

Published: Jan. 1, 2022

Language: Английский

Citations

86
Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications DOI Creative Commons

Lamia Ben Ezzdine,

Wissem Dhahbi, Ismail Dergaa

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 28, 2025

This review aimed to elucidate the mechanisms through which (i) physical activity (PA) enhances neuroplasticity and cognitive function in neurodegenerative disorders, (ii) identify specific PA interventions for improving rehabilitation programs. We conducted a literature search PubMed, Medline, Scopus, Web of Science, PsycINFO, covering publications from January 1990 August 2024. The strategy employed key terms related neuroplasticity, exercise, function, personalized activity. Inclusion criteria included original research on relationship between while exclusion eliminated studies focusing solely pharmacological interventions. identified multiple pathways may enhance including releasing neurotrophic factors, modulation neuroinflammation, reduction oxidative stress, enhancement synaptic connectivity neurogenesis. Aerobic exercise was found increase hippocampal volume by 1–2% improve executive scores 5–10% older adults. Resistance training enhanced control memory performance 12–18% elderly individuals. Mind–body exercises, such as yoga tai-chi, improved gray matter density memory-related brain regions 3–5% emotional regulation 15–20%. Dual-task attention processing speed 8–14% individuals with disorders. also discuss potential role AI-based AI preventing rehabilitating illnesses, highlighting innovative approaches patient outcomes. significantly disorders various mechanisms. resistance training, mind–body practices, dual-task exercises each offer unique benefits. Implementing these activities clinical settings can Future should focus creating tailored conditions, incorporating programs optimize rehabilitation.

Language: Английский

Citations

4
Prey capture learning drives critical period-specific plasticity in mouse binocular visual cortex DOI Creative Commons
Diane Bissen, Brian Cary, Amanda Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Summary Critical periods are developmental windows of high experience-dependent plasticity essential for the correct refinement neuronal circuitry and function. While consequences visual system sensory deprivation during critical period have been well-characterized, far less is known about effects enhanced experience. Here, we use prey capture learning to assess structural functional mediating in primary cortex mice. We show that improves temporal frequency discrimination drives a profound remodeling through an increase excitatory connectivity spine turnover. This global persistent rewiring not observed adult hunters mediated by TNFα-dependent mechanisms. Our findings demonstrate experience naturalistic paradigm can drive improve function, promotes long-lasting dynamics could enhance subsequent plasticity.

Language: Английский

Citations

3
Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism DOI Creative Commons
Lucas Cheadle, Samuel A. Rivera, Jasper S. Phelps

et al.

Neuron, Journal Year: 2020, Volume and Issue: 108(3), P. 451 - 468.e9

Published: Sept. 14, 2020

Language: Английский

Citations

131
Shifting Developmental Trajectories During Critical Periods of Brain Formation DOI Creative Commons
Nathalie Dehorter, Isabel del Pino

Frontiers in Cellular Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Sept. 10, 2020

Research on critical periods of brain development is greatly expanding our understanding the cellular and molecular mechanisms underlying epochs heightened plasticity driven by environmental influence. Novel studies have started to reveal that timely interventions during hold potential reorient abnormal developmental trajectories in animal models neurological neuropsychiatric disorders. In this review, we re-examine fundamental criteria characterize a period, highlighting recently discovered health disease. addition, touch upon technological improvements modelling human-derived neural networks vitro. These scientific advances associated with use manipulations immature represent promising new preclinical setting will allow future translatability into clinical applications for neurodevelopmental disorders such as intellectual disability, autism spectrum schizophrenia.

Language: Английский

Citations

102
Neuron class–specific responses govern adaptive myelin remodeling in the neocortex DOI
Sung Min Yang,

Katrin Michel,

Vahbiz Jokhi

et al.

Science, Journal Year: 2020, Volume and Issue: 370(6523)

Published: Dec. 18, 2020

Cellular effects of visual deprivation Myelination speeds the progress action potentials along neuronal axons. Yang et al. studied changes in myelination mouse cortex response to experience (see Perspective by Yalçin and Monje). With normal vision, is continuously remodeled. As ocular dominance shifts monocular deprivation, patterns change on certain inhibitory interneurons but not excitatory callosal projection neurons. Myelin sheaths are both added subtracted, segments myelin elongate contract, preexisting oligodendrocytes make new sheaths. This adaptive helps diversify function remodel circuits sensory experience. Science , this issue p. eabd2109 ; see also 1414

Language: Английский

Citations

101
Activity-dependent modulation of synapse-regulating genes in astrocytes DOI Creative Commons
Isabella Farhy-Tselnicker,

Matthew Boisvert,

Hanqing Liu

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Sept. 8, 2021

Astrocytes regulate the formation and function of neuronal synapses via multiple signals; however, what controls regional temporal expression these signals during development is unknown. We determined profile astrocyte synapse-regulating genes in developing mouse visual cortex, identifying that show differential layer-enriched expression. These patterns are not intrinsic to astrocytes, but regulated by visually evoked activity, as they absent mice lacking glutamate release from thalamocortical terminals. Consequently, remain immature. Expression synaptic also altered when signaling blunted diminishing calcium stores. Single-nucleus RNA sequencing identified groups astrocytic a cassette layer-specific enrichment. Thus, cortical circuits requires coordinated between astrocytes neurons, highlighting target manipulate neurodevelopmental disorders.

Language: Английский

Citations

92
Microglia, Cytokines, and Neural Activity: Unexpected Interactions in Brain Development and Function DOI Creative Commons
Austin Ferro,

Yohan S. S. Auguste,

Lucas Cheadle

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 1, 2021

Intercellular signaling molecules such as cytokines and their receptors enable immune cells to communicate with one another surrounding microenvironments. Emerging evidence suggests that the same pathways regulate inflammatory responses injury disease outside of brain also play powerful roles in development, plasticity, function. These observations raise question how can distinct peripheral tissues compared central nervous system, a system previously thought be largely protected from signaling. Here, we review specialized are large extent shaped by neural activity, key feature reflects active communication between neurons at synapses. We discuss known mechanisms through which microglia, resident brain, respond increases decreases activity engaging classical cascades assemble, remodel, eliminate synapses across lifespan. integrate (1) vivo imaging studies microglia-neuron interactions, (2) developmental multiple circuits, (3) molecular activity-dependent gene expression microglia highlight specific defining pathway function brain. Given repurposing different may an important evolutionary strategy overcome limited size genome, understanding cytokine is established maintained could lead insights into neurological health disease.

Language: Английский

Citations

87
Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly DOI Creative Commons
Lu Chen, Xiling Li, Michelle Tjia

et al.

Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 75, P. 102553 - 102553

Published: May 17, 2022

Language: Английский

Citations

69