Journal of Neuroscience,
Journal Year:
2021,
Volume and Issue:
41(25), P. 5553 - 5565
Published: May 18, 2021
The
hypokinetic
motor
symptoms
of
Parkinson's
disease
(PD)
are
closely
linked
with
a
decreased
cortical
output
as
consequence
elevated
basal
ganglia
inhibition.
However,
whether
and
how
the
loss
dopamine
(DA)
alters
cellular
properties
neurons
in
PD
remains
undefined.
We
induced
parkinsonism
adult
C57BL/6
mice
both
sexes
by
injecting
neurotoxin,
6-hydroxydopamine
(6-OHDA),
into
medial
forebrain
bundle.
By
using
Neuron,
Journal Year:
2018,
Volume and Issue:
99(5), P. 1040 - 1054.e5
Published: Aug. 23, 2018
Motor
cortex
(M1)
lesions
result
in
motor
impairments,
yet
how
M1
contributes
to
the
control
of
movement
remains
controversial.
To
investigate
role
sensory
guided
coordination,
we
trained
mice
navigate
a
virtual
corridor
using
spherical
treadmill.
This
task
required
directional
adjustments
through
spontaneous
turning,
while
unexpected
visual
offset
perturbations
prompted
induced
turning.
We
found
that
is
essential
for
execution
and
learning
this
visually
task.
Turn-selective
layer
2/3
5
pyramidal
tract
(PT)
neuron
activation
was
shaped
differentially
with
but
scaled
linearly
turn
acceleration
during
turns.
During
turns,
however,
neurons
were
activated
independent
behavioral
response,
PT
still
encoded
response
magnitude.
Our
results
are
consistent
detection
deviations
from
intended
state
initiation
an
appropriate
corrective
response.
Frontiers in Systems Neuroscience,
Journal Year:
2019,
Volume and Issue:
12
Published: Jan. 8, 2019
Cortical
neurons
process
information
on
a
background
of
spontaneous,
ongoing
activity
with
distinct
spatiotemporal
profiles
defining
different
cortical
states.
During
wakefulness,
states
alter
constantly
in
relation
to
behavioral
context,
attentional
level
or
general
motor
activity.
In
this
review,
we
will
discuss
our
current
understanding
awake
rodents,
how
they
are
controlled,
their
impact
sensory
processing,
and
highlight
areas
for
future
research.
A
common
observation
rodents
is
the
rapid
change
spontaneous
from
high-amplitude,
low-frequency
fluctuations,
when
animals
quiet,
faster
smaller
fluctuations
active.
This
transition
typically
thought
as
global
brain
state
but
recent
work
has
shown
variation
across
regions,
indicating
presence
fine
spatial
scale
control
system.
areas,
mediated
by
at
least
two
convergent
inputs,
one
thalamus
other
cholinergic
inputs
basal
forebrain.
have
major
balance
between
specific
subtypes
neurons,
synchronization
nearby
well
functional
coupling
distant
areas.
reorganization
networks
strongly
affects
processing.
Thus
provide
dynamic
system
moment-by-moment
regulation
Cell Reports,
Journal Year:
2017,
Volume and Issue:
20(2), P. 308 - 318
Published: July 1, 2017
The
control
of
targeted
reaching
is
thought
to
be
shaped
by
distinct
subtypes
local
GABAergic
inhibitory
neurons
in
primary
forelimb
motor
cortex
(M1).
However,
little
known
about
their
action
potential
firing
dynamics
during
reaching.
To
address
this,
we
recorded
the
activity
parvalbumin-expressing
(PV+)
identified
from
a
larger
population
fast-spiking
units
and
putative
excitatory
regular-spiking
layer
5
mouse
M1
an
M1-dependent,
sensory-triggered
task.
PV+
showed
short
latency
responses
acoustic
cue
vibrotactile
trigger
stimulus
increase
at
onset
that
scaled
with
amplitude
Unexpectedly,
fired
before
reach
high
overall
rates
both
spontaneous
reaches.
Our
data
suggest
increasing
neuron
may
play
role
initiation
voluntary
Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
38(44), P. 9402 - 9413
Published: Oct. 31, 2018
Motor
and
premotor
cortices
are
crucial
for
the
control
of
movements.
However,
we
still
know
little
about
how
these
areas
contribute
to
higher-order
motor
control,
such
as
deciding
which
movements
make
when
them.
Here
focus
on
rodent
studies
review
recent
findings,
suggest
that-in
addition
control-neurons
in
play
a
role
sensory
integration,
behavioral
strategizing,
working
memory,
decision-making.
We
that
seemingly
disparate
functions
may
subserve
an
evolutionarily
conserved
sensorimotor
cognition
further
study
could
major
contribution
our
understanding
evolution
function
mammalian
frontal
cortex.
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: Jan. 17, 2018
Cortical
computation
is
distributed
across
multiple
areas
of
the
cortex
by
networks
reciprocal
connectivity.
However,
how
such
connectivity
contributes
to
communication
between
connected
not
clear.
In
this
study,
we
examine
sensory
and
motor
cortices.
We
develop
an
eye
movement
task
in
mice
combine
it
with
optogenetic
suppression
two-photon
calcium
imaging
techniques.
identify
a
small
region
secondary
(MOs)
that
controls
movements
reciprocally
connects
rostrolateral
part
higher
visual
(VRL/A/AL).
These
two
regions
encode
both
signals
information;
however,
information
flow
depends
on
direction
connectivity:
conveyed
preferentially
from
MOs
VRL/A/AL,
transferred
primarily
opposite
direction.
propose
streamlines
flow,
enhancing
computational
capacity
network.
