Predictive Processing: A Canonical Cortical Computation

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 424 - 435

Published: Oct. 1, 2018

Language: Английский

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2022 roadmap on neuromorphic computing and engineering

Neuromorphic Computing and Engineering, Journal Year: 2022, Volume and Issue: 2(2), P. 022501 - 022501

Published: Jan. 12, 2022

Abstract Modern computation based on von Neumann architecture is now a mature cutting-edge science. In the architecture, processing and memory units are implemented as separate blocks interchanging data intensively continuously. This transfer responsible for large part of power consumption. The next generation computer technology expected to solve problems at exascale with 10 18 calculations each second. Even though these future computers will be incredibly powerful, if they type architectures, consume between 20 30 megawatts not have intrinsic physically built-in capabilities learn or deal complex our brain does. These needs can addressed by neuromorphic computing systems which inspired biological concepts human brain. new has potential used storage amounts digital information much lower consumption than conventional processors. Among their applications, an important niche moving control from centers edge devices. aim this roadmap present snapshot state provide opinion challenges opportunities that holds in major areas technology, namely materials, devices, circuits, algorithms, ethics. collection perspectives where leading researchers community own view about current research area. We hope useful resource providing concise yet comprehensive introduction readers outside field, those who just entering well established community.

Language: Английский

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Pupil Size as a Window on Neural Substrates of Cognition

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(6), P. 466 - 480

Published: April 21, 2020

Language: Английский

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Dopamine and Cognitive Control in Prefrontal Cortex

Trends in Cognitive Sciences, Journal Year: 2019, Volume and Issue: 23(3), P. 213 - 234

Published: Jan. 31, 2019

Language: Английский

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Mechanisms underlying gain modulation in the cortex

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(2), P. 80 - 92

Published: Jan. 7, 2020

Language: Английский

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Neuromodulatory Influences on Integration and Segregation in the Brain

Trends in Cognitive Sciences, Journal Year: 2019, Volume and Issue: 23(7), P. 572 - 583

Published: May 8, 2019

Language: Английский

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Dynamic coupling of whole-brain neuronal and neurotransmitter systems

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(17), P. 9566 - 9576

Published: April 13, 2020

Significance In a technical tour de force, we have created framework demonstrating the underlying fundamental principles of bidirectional coupling neuronal and neurotransmitter dynamical systems. Specifically, in present study, combined multimodal neuroimaging data to causally explain functional effects specific serotoninergic receptor (5-HT 2A R) stimulation with psilocybin healthy humans. Longer term, this could provide better understanding why is showing considerable promise as therapeutic intervention for neuropsychiatric disorders including depression, anxiety, addiction.

Language: Английский

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Neuromodulation of Brain State and Behavior

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 391 - 415

Published: April 6, 2020

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans animals reveal that these variations not random their nature, but may fact be due large part to rapid shifts neural, cognitive, behavioral states. Here we review recent advances the understanding waking state, how generated, they modulate neural mice humans. We propose brain has an identifiable set states through which it wanders continuously a nonrandom fashion, owing ascending modulatory fast-acting corticocortical subcortical-cortical pathways. These state provide backdrop upon operates, them is critical making progress revealing mechanisms underlying cognition behavior.

Language: Английский

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Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Cells, Journal Year: 2021, Volume and Issue: 10(4), P. 735 - 735

Published: March 26, 2021

Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement behavior, selected higher cognitive functions. Dysfunction dopaminergic transmission recognized as core alteration several devastating neurological psychiatric disorders, Parkinson’s disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) addiction. Here we will discuss the current insights on role DA control learning mechanisms its involvement synaptic dynamics through different pathways. In particular, consider neuromodulator two forms plasticity, known long-term potentiation (LTP) depression (LTD) cortical subcortical areas. Finally, delineate how effect dendritic spines places this molecule at interface between systems. Specifically, be focusing PD, vascular dementia, schizophrenia.

Language: Английский

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Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(6), P. 765 - 776

Published: May 6, 2021

Language: Английский

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