Neuron, Journal Year: 2021, Volume and Issue: 109(22), P. 3576 - 3593
Published: Sept. 27, 2021
Language: Английский
Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2289 - 2303
Published: May 9, 2024
The property of mixed selectivity has been discussed at a computational level and offers strategy to maximize power by adding versatility the functional role each neuron. Here, we offer biologically grounded implementational-level mechanistic explanation for in neural circuits. We define pure, linear, nonlinear discuss how these response properties can be obtained simple Neurons that respond multiple, statistically independent variables display selectivity. If their activity expressed as weighted sum, then they exhibit linear selectivity; otherwise, Neural representations based on diverse are high dimensional; hence, confer enormous flexibility downstream readout circuit. However, circuit cannot possibly encode all possible mixtures simultaneously, this would require combinatorially large number neurons. Gating mechanisms like oscillations neuromodulation solve problem dynamically selecting which transmitted readout.
Language: Английский
Citations
33
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 176 - 194
Published: Jan. 23, 2024
Language: Английский
Citations
17
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 2, 2025
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging in mice, we tracked NAc shell D1- D2-medium spiny neurons' (MSNs) activity during exposure to of opposing valence and associative learning. Despite drift individual coding, both D2-population was sufficient discriminate unconditioned stimuli, but not predictive cues. Notably, D2-MSNs were similarly co-recruited conditioning, supporting concurrent role Conversely, when contingencies changed, there an asymmetric response the NAc, with more pronounced changes D2-MSNs. Optogenetic manipulation provided causal evidence necessity this population extinction associations. Our results reveal neurons valence, Pavlovian associations their extinction, unveil mechanisms underlying behaviors. rewarding Here, authors show that appeared be relevant
Language: Английский
Citations
2
Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(4), P. 576 - 585
Published: March 4, 2019
Language: Английский
Citations
122
eLife, Journal Year: 2019, Volume and Issue: 8
Published: April 4, 2019
The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and anxiety, but specific factors that engage BNST defensive behaviors are unclear. Here we examined whether mediates freezing to stimuli (CSs) poorly predict onset aversive unconditioned (USs) rats. Reversible inactivation selectively reduced CSs signaled US (e.g., a backward CS followed US), did not eliminate forward even when they predicted USs variable intensity. Additionally, (but forward) increased Fos ventral BNST-projecting neurons infralimbic region medial prefrontal cortex (mPFC), hippocampus or amygdala. These data reveal circuits regulate unpredictable threats, which may be critical etiology expression anxiety.
Language: Английский
Citations
109
Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)
Published: Aug. 1, 2019
Abstract Feeding is known to be profoundly affected by stress-related emotional states and eating disorders are comorbid with psychiatric symptoms altered responses. The neural basis underlying feeding regulation changes poorly understood. Here, we identify a novel projection from the paraventricular hypothalamus (PVH) ventral lateral septum (LSv) that shows scalable on behavioral related emotion. Weak photostimulation of glutamatergic PVH→LSv terminals elicits self-grooming strong causes fear-related escape jumping associated respective weak inhibition feeding. In contrast, inputs LSv increases signs reduced anxiety. LSv-projecting neurons concentrated in rostral PVH. PVH activated stressors vivo, whereas bouts were activity these neurons. Thus, neurotransmission underlies dynamic orchestrating states, providing circuit substrate comorbidity between abnormalities disorders.
Language: Английский
Citations
91
Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(11), P. 1586 - 1600
Published: Oct. 18, 2021
Language: Английский
Citations
90
Frontiers in Behavioral Neuroscience, Journal Year: 2020, Volume and Issue: 14
Published: March 10, 2020
The affective state is the combination of emotion and mood, with mood reflecting a running average sequential emotional events together an underlying internal state. There now extensive evidence that odors can overtly or subliminally modulate emotion. Relying primarily on neurobiological literature, here we review what known about how affect emotions/moods may odor perception. We take approach form provide insight into function by reviewing major brain regions neural circuits then olfactory pathway in context emotion/mood network. highlight neuroanatomical opportunities for odor-emotion/mood convergence, as well functional data demonstrating reciprocal interactions between these processes. Finally, explore odor- interplay is, could be, used medical and/or commercial applications.
Language: Английский
Citations
89
Neuron, Journal Year: 2020, Volume and Issue: 105(6), P. 1062 - 1076.e6
Published: Jan. 13, 2020
Language: Английский
Citations
86
Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(7), P. 538 - 549
Published: March 25, 2021
Language: Английский
Citations
85