Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 22, 2022
Abstract
Appropriate
processing
of
reward
and
aversive
information
is
essential
for
survival.
Although
a
critical
role
serotonergic
neurons
in
the
dorsal
raphe
nucleus
(DRN)
has
been
shown,
lack
rewarding
effects
with
selective
serotonin
reuptake
inhibitors
(SSRIs)
implies
presence
discrete
system
playing
an
opposite
to
DRN
stimuli.
Here,
we
demonstrated
that
median
(MRN)
mice
process
directions
neurons.
We
further
identified
MRN
neurons,
including
those
projecting
interpeduncular
(5-HT
MRN→IPN
),
as
key
mediator
Moreover,
5-HT
receptors,
2A
receptors
nucleus,
are
involved
properties
neural
activity.
Our
findings
revealed
function
,
Neurobiology of Stress,
Journal Year:
2019,
Volume and Issue:
11, P. 100191 - 100191
Published: Aug. 13, 2019
Stress
and
anxiety
have
intertwined
behavioral
neural
underpinnings.
These
commonalities
are
critical
for
understanding
each
state,
as
well
their
mutual
interactions.
Grasping
the
mechanisms
underlying
this
bidirectional
relationship
will
major
clinical
implications
managing
a
wide
range
of
psychopathologies.
After
briefly
defining
key
concepts
study
stress
in
pre-clinical
models,
we
present
circuit,
cellular
molecular
involved
either
or
both
anxiety.
First,
review
studies
on
divergent
circuits
basolateral
amygdala
(BLA)
emotional
valence
processing
anxiety-like
behaviors,
how
norepinephrine
inputs
from
locus
coeruleus
(LC)
to
BLA
responsible
acute-stress
induced
We
then
describe
recent
revealing
new
role
mitochondrial
function
within
nucleus
accumbens
(NAc),
individual
trait
rodents,
participating
link
between
Next,
report
findings
impact
reward
encoding
through
alteration
circuit
dynamic
synchronicity.
Finally,
work
unravelling
hypothalamic
corticotropin-releasing
hormone
(CRH)
neurons
controlling
stress-induce
behaviors.
Altogether,
research
reviewed
here
reveals
sharing
subcortical
nodes
Understanding
overlap
these
two
psychobiological
states,
might
provide
alternative
strategies
manage
disorders
such
post-traumatic
disorder
(PTSD).
Science,
Journal Year:
2020,
Volume and Issue:
370(6514)
Published: Oct. 16, 2020
How
neuron
types
encode
behavioral
states
What
is
the
contribution
of
molecularly
defined
cell
to
neural
coding
stimuli
and
states?
Xu
et
al.
aimed
evaluate
representation
multiple
in
mouse
paraventricular
hypothalamus.
To
achieve
this
goal,
they
combined
deep-brain
two-photon
imaging
with
post
hoc
validation
gene
expression
imaged
cells.
The
could
be
well
predicted
by
response
neuronal
clusters.
Some
clusters
were
broadly
tuned
contributed
strongly
decoding
states,
whereas
others
more
specifically
certain
behaviors
or
specific
time
windows
a
state.
Science
,
issue
p.
eabb2494
Science,
Journal Year:
2023,
Volume and Issue:
382(6672)
Published: Nov. 16, 2023
Neuropeptides
are
key
signaling
molecules
in
the
endocrine
and
nervous
systems
that
regulate
many
critical
physiological
processes.
Understanding
functions
of
neuropeptides
vivo
requires
ability
to
monitor
their
dynamics
with
high
specificity,
sensitivity,
spatiotemporal
resolution.
However,
this
has
been
hindered
by
lack
direct,
sensitive,
noninvasive
tools.
We
developed
a
series
GRAB
(G
protein-coupled
receptor
activation‒based)
sensors
for
detecting
somatostatin
(SST),
corticotropin-releasing
factor
(CRF),
cholecystokinin
(CCK),
neuropeptide
Y
(NPY),
neurotensin
(NTS),
vasoactive
intestinal
peptide
(VIP).
These
fluorescent
sensors,
which
enable
detection
specific
binding
at
nanomolar
concentrations,
establish
robust
tool
kit
studying
release,
function,
regulation
under
both
pathophysiological
conditions.
