Molecular Psychiatry,
Journal Year:
2019,
Volume and Issue:
26(4), P. 1178 - 1193
Published: Aug. 14, 2019
Abstract
Opioids,
such
as
morphine,
are
clinic
analgesics
which
induce
euphoria.
Morphine
exposure
modifies
the
excitability
and
functional
interactions
between
neurons,
while
underlying
cellular
molecular
mechanisms,
especially
how
morphine
assembles
heterogeneous
interneurons
(INs)
in
prelimbic
cortex
(PrL)
to
mediate
disinhibition
reward,
not
clear.
Using
approaches
of
optogenetics,
electrophysiology,
cell
type-specific
RNA-seq,
we
show
that
attenuates
inhibitory
synaptic
transmission
from
parvalbumin
+
(PV)-INs
onto
pyramidal
neurons
PrL
via
μ-opioid
receptor
(MOR)
PV-INs.
Meanwhile,
enhances
inputs
somatostatin
(SST)-INs
PV-INs,
thus
disinhibits
δ-opioid
(DOR)-dependent
Rac1
upregulation
SST-INs.
We
MOR
PV-INs
is
required
for
morphine-induced
behavioral
sensitization,
DOR
well
activity
SST-INs
conditioned
place
preference
hyper-locomotion.
These
results
reveal
SST-
functioning
a
disinhibitory
architecture,
coordinated
by
different
opioid
receptors
disinhibit
enhance
reward.
Physiological Genomics,
Journal Year:
2019,
Volume and Issue:
51(9), P. 432 - 442
Published: Aug. 2, 2019
The
medial
prefrontal
cortex
(mPFC)
is
a
crucial
cortical
region
that
integrates
information
from
numerous
and
subcortical
areas
converges
updated
to
output
structures.
It
plays
essential
roles
in
the
cognitive
process,
regulation
of
emotion,
motivation,
sociability.
Dysfunction
mPFC
has
been
found
various
neurological
psychiatric
disorders,
such
as
depression,
anxiety
schizophrenia,
autism
spectrum
Alzheimer's
disease,
Parkinson's
addiction.
In
present
review,
we
summarize
preclinical
clinical
studies
illustrate
role
these
diseases.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 21, 2020
Abstract
Social
isolation
during
the
juvenile
critical
window
is
detrimental
to
proper
functioning
of
prefrontal
cortex
(PFC)
and
establishment
appropriate
adult
social
behaviors.
However,
specific
circuits
that
undergo
experience-dependent
maturation
regulate
behavior
are
poorly
understood.
We
identify
a
activation
pattern
parvalbumin-positive
interneurons
(PVIs)
in
dorsal-medial
PFC
(dmPFC)
prior
an
active
bout,
or
bout
initiated
by
focal
mouse,
but
not
passive
when
mice
explored
stimulus
mouse.
Optogenetic
chemogenetic
manipulation
reveals
brief
dmPFC-PVI
triggers
approach
promote
sociability.
Juvenile
decouples
from
subsequent
freezing
functional
process
dmPFC-PVIs
juvenile-to-adult
transition.
Chemogenetic
activity
animal
mitigates
isolation-induced
deficits.
Therefore,
linked
long-term
impacts
on
behavior.
Cell Reports,
Journal Year:
2021,
Volume and Issue:
34(12), P. 108874 - 108874
Published: March 1, 2021
Exposure
to
prolonged
stress
in
critical
developmental
periods
induces
heightened
vulnerability
psychiatric
disorders,
which
may
have
sex-specific
consequences.
Here
we
investigate
the
neuronal
circuits
mediating
behavioral
changes
mice
after
chronic
adolescent
social
isolation
stress.
Escalated
aggression
is
exhibited
stressed
males,
while
withdrawal
shown
females.
In
vivo
multichannel
recordings
of
free-moving
animals
indicate
that
pyramidal
neurons
prefrontal
cortex
(PFC)
from
males
exhibit
significantly
decreased
spike
activity
during
aggressive
attacks,
PFC
females
show
a
blunted
increase
discharge
rates
sociability
tests.
Chemogenetic
and
electrophysiological
evidence
shows
hypofunctioning
BLA
principal
neuron
hyperactivity
contribute
elevated
VTA
dopamine
hypoactivity
diminished
These
results
establish
framework
for
understanding
circuit
physiological
mechanisms
underlying
divergent
effects
