Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila DOI Creative Commons
Neil Zhang, Li Guo, J. Simpson

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(6), P. 988 - 1001.e4

Published: March 1, 2020

Animals integrate information from different sensory modalities, body parts, and time points to inform behavioral choice, but the relevant comparisons underlying neural circuits are still largely unknown. We use grooming behavior of Drosophila melanogaster as a model investigate that govern motor sequence. Flies perform movements spontaneously, when covered with dust, they clean their bodies following an anterior-to-posterior After investigating modalities could detect we focus on mechanosensory bristle neurons, whose optogenetic activation induces similar Computational modeling predicts higher input strength head will cause anterior occur first. test this prediction using competition assay whereby two targeted light beams independently activate neurons parts. find initial choice movement is determined by ratio inputs In dust-covered flies, change result successful cleaning movements. Simulations our suggest results in sequence progression. One possibility flies frequent between posterior inputs, changing ratios drive choices. Alternatively, may track temporal given part measure effectiveness. The first hypothesis supported experiments: iterative spatial parts essential for organizing

Language: Английский

A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection DOI Creative Commons
Brad K. Hulse, Hannah Haberkern, Romain Franconville

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 26, 2021

Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of

Language: Английский

Citations

304
Insect Odorscapes: From Plant Volatiles to Natural Olfactory Scenes DOI Creative Commons
Lucie Conchou, Philippe Lucas, Camille Meslin

et al.

Frontiers in Physiology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 2, 2019

Olfaction is an essential sensory modality for insects and their olfactory environment mostly made up of plant-emitted volatiles. The terrestrial vegetation produces amazing diversity volatile compounds, which are then transported, mixed, degraded in the atmosphere. Each insect species expresses a set receptors that bind part compounds present its habitat. Insect odorscapes thus defined as species-specific spaces, dependent on local habitat, dynamic time. Manipulations pest-insect promising approach to answer strong demand pesticide-free plant-protection strategies. Moreover, understanding becomes major concern context global change environmental stresses populations. A considerable amount information available identity volatiles mediating biotic interactions involve insects. However, large body research devoted how use olfaction locate resources, integrative vision has rarely been reached. This article aims better apprehend nature odorscape importance behavioral ecology by reviewing literature specific different disciplines from plant ecophysiology neuroethology. First, we discuss determinants composition, production plants (section "Plant Metabolism Volatile Emissions") filtering during detection system "Insect Olfaction: How Plant Compounds Are Encoded Integrated Olfactory System"). We summarize physical chemical processes chemicals distribute space "Transportation Spatial Aspects Odorscape") time "Temporal Aspects: Dynamics following sections consider ecological background odors adapt environment. Habitat provides odor modulate responses pheromones other signals "Ecological Importance Odorscapes"). In addition, do not respond inflexibly single elements but integrate several components "Plasticity Adaptation Complex Variable finally existing methods manipulation sustainable pest control potential future developments agroecology "Odorscapes Protection Agroecology").

Language: Английский

Citations

179
Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain DOI Creative Commons
Alexander Shakeel Bates, Philipp Schlegel, Ruairí J.V. Roberts

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(16), P. 3183 - 3199.e6

Published: July 2, 2020

Nervous systems contain sensory neurons, local projection and motor neurons. To understand how these building blocks form whole circuits, we must distil broad classes into neuronal cell types describe their network connectivity. Using an electron micrograph dataset for entire Drosophila melanogaster brain, reconstruct the first complete inventory of olfactory projections connecting antennal lobe, insect analog mammalian bulb, to higher-order brain regions in adult animal brain. We then connect this extant data literature, providing synaptic-resolution "holotypes" both heavily investigated previously unknown types. Projection neurons are approximately twice as numerous reported by light level studies; stereotyped, but not identical, synapse numbers between hemispheres. The lateral horn, cortical amygdala, is main target information has been shown guide innate behavior. Here, find new connectivity motifs, including axo-axonic feedback, inhibition axons a large population convergence different inputs, non-olfactory inputs memory-related feedback onto third-order These features less prominent mushroom body calyx, piriform cortex center associative memory. Our work provides neuroanatomical platform future studies system.

Language: Английский

Citations

175
Generation of stable heading representations in diverse visual scenes DOI
Sung Soo Kim, Ann M. Hermundstad, Sandro Romani

et al.

Nature, Journal Year: 2019, Volume and Issue: 576(7785), P. 126 - 131

Published: Nov. 20, 2019

Language: Английский

Citations

162
A neural circuit for wind-guided olfactory navigation DOI Creative Commons
Andrew M. M. Matheson, Aaron J. Lanz,

Ashley M. Medina

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 8, 2022

Abstract To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction location. Where and how these two are integrated to support navigation is unclear. Here we describe pathway the Drosophila fan-shaped body that encodes attractive promotes upwind navigation. We show neurons throughout this encode odor, but not direction. Using connectomics, identify local called h∆C receive input from previously described pathway. exhibit odor-gated, direction-tuned activity, sparse activation of in reproducible direction, activity required for persistent orientation during odor. Based on connectome data, develop computational model showing can promote goal such as an source. Our results suggest processed by separate pathways within goal-directed

Language: Английский

Citations

92
Neural dynamics and architecture of the heading direction circuit in zebrafish DOI Creative Commons
Luigi Petrucco, Hagar Lavian,

You Kure Wu

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(5), P. 765 - 773

Published: April 24, 2023

Abstract Animals generate neural representations of their heading direction. Notably, in insects, direction is topographically represented by the activity neurons central complex. Although head cells have been found vertebrates, connectivity that endows them with properties unknown. Using volumetric lightsheet imaging, we find a topographical representation neuronal network zebrafish anterior hindbrain, where sinusoidal bump rotates following directional swims fish and otherwise stable over many seconds. Electron microscopy reconstructions show that, although cell bodies are located dorsal region, these arborize interpeduncular nucleus, reciprocal inhibitory stabilizes ring attractor encodes heading. These resemble those fly complex, showing similar circuit architecture principles may underlie across animal kingdom paving way to an unprecedented mechanistic understanding networks vertebrates.

Language: Английский

Citations

57
Generating parallel representations of position and identity in the olfactory system DOI Creative Commons
István Taisz, Erika Donà, Daniel Münch

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(12), P. 2556 - 2573.e22

Published: May 25, 2023

In Drosophila, a dedicated olfactory channel senses male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in 5-mm range around male. Second-order projection encode the angular position of by detecting inter-antennal concentration, which are amplified through contralateral inhibition. At third circuit layer, identify 47 cell types with diverse input-output connectivity. One population responds tonically flies, second is tuned looming, integrates taste coincidentally promote mating. The separation features resembles mammalian what where visual streams; together multisensory integration, this enables behavioral responses appropriate specific ethological contexts.

Language: Английский

Citations

43
A Neural Network for Wind-Guided Compass Navigation DOI Creative Commons

Tatsuo S. Okubo,

Paola Patella, Isabel D’Alessandro

et al.

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 924 - 940.e18

Published: July 17, 2020

Spatial maps in the brain are most accurate when they linked to external sensory cues. Here, we show that compass Drosophila is direction of wind. Shifting wind rightward rotates as if fly were turning leftward, and vice versa. We describe mechanisms several computations integrate information into compass. First, an intensity-invariant representation computed by comparing left-right mechanosensory signals. Then, signals reformatted reduce coding biases inherent peripheral mechanics, cues brought same circular coordinate system represents visual self-motion Because incorporates both cues, it should enable navigation under conditions where no single cue consistently reliable. These results how local can be transformed a global, multimodal, abstract space.

Language: Английский

Citations

106
Flexible navigational computations in the Drosophila central complex DOI
Yvette E. Fisher

Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 73, P. 102514 - 102514

Published: Feb. 19, 2022

Language: Английский

Citations

56
Odour motion sensing enhances navigation of complex plumes DOI
Nirag Kadakia, Mahmut Demir,

Brenden T. Michaelis

et al.

Nature, Journal Year: 2022, Volume and Issue: 611(7937), P. 754 - 761

Published: Nov. 9, 2022

Language: Английский

Citations

48