VTA GABA Neurons at the Interface of Stress and Reward

Frontiers in Neural Circuits, Journal Year: 2019, Volume and Issue: 13

Published: Dec. 5, 2019

The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, aversion. However, the VTA not only made of dopamine (DA) cells, as approximately 35% cells are GABA neurons. These neurons play a dual role, provide both local inhibition DA long-range several distal brain regions. have increasingly been recognized potent mediators reward aversion own right, well potential targets treatment addiction, depression, other stress-linked disorders. In this review, we dissect circuit architecture, physiology, behavioral roles suggest gaps be addressed.

Language: Английский

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Unraveling circuits of visual perception and cognition through the superior colliculus

Neuron, Journal Year: 2021, Volume and Issue: 109(6), P. 918 - 937

Published: Feb. 6, 2021

The superior colliculus is a conserved sensorimotor structure that integrates visual and other sensory information to drive reflexive behaviors. Although the evidence for this strong compelling, number of experiments reveal role in behaviors usually associated with cerebral cortex, such as attention decision-making. Indeed, addition collicular outputs targeting brainstem regions controlling movements, also has ascending projections linking it forebrain structures including basal ganglia amygdala, highlighting fact colliculus, its vast inputs outputs, can influence processing throughout neuraxis. Today, modern molecular genetic methods combined sophisticated behavioral assessments have potential make significant breakthroughs our understanding evolution conservation neuronal cell types circuits give rise simple complex

Language: Английский

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A specific circuit in the midbrain detects stress and induces restorative sleep

Science, Journal Year: 2022, Volume and Issue: 377(6601), P. 63 - 72

Published: June 30, 2022

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how promotes is unclear. Activity-dependent tagging revealed a subset of ventral tegmental area γ-aminobutyric acid (GABA)-somatostatin (VTA

Language: Английский

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Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 85, P. 101840 - 101840

Published: Jan. 2, 2023

Language: Английский

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The Formation and Function of the VTA Dopamine System

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3875 - 3875

Published: March 30, 2024

The midbrain dopamine system is a sophisticated hub that integrates diverse inputs to control multiple physiological functions, including locomotion, motivation, cognition, reward, as well maternal and reproductive behaviors. Dopamine neurotransmitter binds G-protein-coupled receptors. also works together with other neurotransmitters various neuropeptides maintain the balance of synaptic functions. dysfunction leads several conditions, Parkinson’s disease, Huntington’s major depression, schizophrenia, drug addiction. ventral tegmental area (VTA) has been identified an important relay nucleus modulates homeostatic plasticity in system. Due complexity transmissions input–output connections VTA, structure function this crucial brain region are still not fully understood. In review article, we mainly focus on cell types, neurotransmitters, neuropeptides, ion channels, receptors, neural circuits VTA system, hope obtaining new insight into formation vital region.

Language: Английский

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A distributed subcortical circuit linked to instrumental information-seeking about threat

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(3)

Published: Jan. 15, 2025

Daily life for humans and other animals requires switching between periods of threat- reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, foraging rewards seeking information about potential threats 7T fMRI healthy humans. Switching was driven by estimates likelihood threat reward. Both tracking to vigilant mode which people sought more were specific but distributed patterns spanning habenula, dorsal raphe nucleus (DRN), anterior cingulate cortex, insula cortex. Different aspects the linked monitoring level, threat, actual detection. A distinct pattern same circuit elsewhere occurred during returns Individual variation DRN reflected individual threats.

Language: Английский

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Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity

Neuron, Journal Year: 2019, Volume and Issue: 104(1), P. 63 - 77

Published: Oct. 1, 2019

Language: Английский

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VTA Glutamatergic Neurons Mediate Innate Defensive Behaviors

Neuron, Journal Year: 2020, Volume and Issue: 107(2), P. 368 - 382.e8

Published: May 21, 2020

Language: Английский

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The influence of subcortical shortcuts on disordered sensory and cognitive processing

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 264 - 276

Published: April 8, 2020

Language: Английский

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Corticostriatal control of defense behavior in mice induced by auditory looming cues

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Feb. 15, 2021

Abstract Animals exhibit innate defense behaviors in response to approaching threats cued by the dynamics of sensory inputs various modalities. The underlying neural circuits have been mostly studied visual system, but remain unclear for other Here, utilizing sounds with increasing (vs. decreasing) loudness mimic looming receding) objects, we find that elicit stereotypical sequential defensive reactions: freezing followed flight. Both require activity auditory cortex, particular sustained type responses, are differentially mediated corticostriatal projections primarily innervating D2 neurons tail striatum and corticocollicular superior colliculus, respectively. behavioral transition from flight can be attributed differential temporal striatal collicular their responses sound stimuli. Our results reveal an essential role control.

Language: Английский

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