Convolutional neural networks for vision neuroscience: significance, developments, and outstanding issues DOI Creative Commons
Alessia Celeghin, Alessio Borriero, Davide Orsenigo

et al.

Frontiers in Computational Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 6, 2023

Convolutional Neural Networks (CNN) are a class of machine learning models predominately used in computer vision tasks and can achieve human-like performance through from experience. Their striking similarities to the structural functional principles primate visual system allow for comparisons between these artificial networks their biological counterparts, enabling exploration how functions neural representations may emerge real brain limited set computational principles. After considering basic features CNNs, we discuss opportunities challenges endorsing CNNs as silico system. Specifically, highlight several emerging notions about anatomical physiological properties that still need be systematically integrated into current CNN models. These tenets include implementation parallel processing pathways early stages retinal input reconsideration assumptions concerning serial progression information flow. We suggest design choices architectural constraints could facilitate closer alignment with biology provide causal evidence predictive link systems. Adopting this principled perspective potentially lead new research questions applications beyond modeling object recognition.

Language: Английский

The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action DOI Creative Commons
Tadashi Isa, Emmanuel Márquez-Legorreta, Sten Grillner

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(11), P. R741 - R762

Published: June 1, 2021

The superior colliculus, or tectum in the case of non-mammalian vertebrates, is a part brain that registers events surrounding space, often through vision and hearing, but also electrosensation, infrared detection, other sensory modalities diverse vertebrate lineages. This information used to form maps space positions different salient stimuli relation individual. are arranged layers with visual input uppermost layer, senses deeper positions, spatially aligned motor map deepest layer. Here, we will review organization intrinsic function tectum/superior colliculus processed within tectal circuits. We discuss tectal/superior outputs conveyed directly downstream circuits via thalamus cortical areas control various aspects behavior. evolutionarily conserved among all tailored specialties each lineage, its roles have shifted emergence cerebral cortex mammals. illustrate both divergent properties evolution by comparing processing lampreys belonging oldest group extant larval zebrafish, rodents, vertebrates including primates.

Language: Английский

Citations

142
A neural mechanism for terminating decisions DOI Creative Commons
Gabriel M Stine, Eric M. Trautmann, Danique Jeurissen

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(16), P. 2601 - 2613.e5

Published: June 22, 2023

The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of accumulation are established in association cortex, but the site mechanism termination unknown. Here, we show that superior colliculus (SC) plays a causal role terminating decisions, provide for which this occurs. We recorded simultaneously from neurons lateral intraparietal area (LIP) SC while monkeys made perceptual decisions. Despite similar trial-averaged activity, found distinct single-trial dynamics two areas: LIP displayed drift-diffusion bursting dynamics. hypothesized bursts manifest threshold applied signals represented terminate decision. Consistent with hypothesis, inactivation produced behavioral effects diagnostic an impaired sensor prolonged buildup activity LIP. results reveal transformation deliberation commitment.

Language: Английский

Citations

44
Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease DOI Creative Commons
Wen Wu,

Yubai Zhao,

Xin R. Cheng

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms treatments remain elusive. Here we report therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model disease. Our findings reveal that treatment prevents memory decline 4-month-old mice motivation loss 14-month-old mice, accompanied restoration glial water channel aquaporin-4 polarity, improved brain drainage efficiency, reduction hippocampal lipid accumulation. We further demonstrate beneficial effects are mediated through activation vLGN/IGL-Re visual circuit. Notably, concomitant use anti-Aβ antibody with demonstrates soluble Aβ clearance performance mice. These offer functional evidence on Aβ-related pathologies suggest its as supplementary strategy to augment efficacy antibody-based therapy. Treatments for (AD) limited. Here, authors show activates circuit boost glymphatic drainage, enhances memory, motivation, therapy AD.

Language: Английский

Citations

3
The brain-body disconnect: A somatic sensory basis for trauma-related disorders DOI Creative Commons
Breanne E. Kearney,

Ruth A. Lanius

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Nov. 21, 2022

Although the manifestation of trauma in body is a phenomenon well-endorsed by clinicians and traumatized individuals, neurobiological underpinnings this remain unclear. The notion somatic sensory processing, which encompasses vestibular somatosensory processing relates to systems concerned with how physical exists space, introduced as major contributor overall regulatory, social-emotional, self-referential functioning. From phylogenetically ontogenetically informed perspective, trauma-related symptomology conceptualized be grounded brainstem-level dysfunction its cascading influences on physiological arousal modulation, affect regulation, higher-order capacities. Lastly, we introduce novel hierarchical model bridging processes limbic neocortical mechanisms regulating an individual’s emotional experience sense relational, agentive self. This provides working framework for neurobiologically assessment treatment conditions from perspective.

Language: Английский

Citations

63
Cortical control of behavior and attention from an evolutionary perspective DOI Creative Commons
S. Murray Sherman, W. Martin Usrey

Neuron, Journal Year: 2021, Volume and Issue: 109(19), P. 3048 - 3054

Published: July 22, 2021

Language: Английский

Citations

57
The Superior Colliculus: Cell Types, Connectivity, and Behavior DOI Creative Commons
Xue Liu,

Hongren Huang,

Terrance P. Snutch

et al.

Neuroscience Bulletin, Journal Year: 2022, Volume and Issue: 38(12), P. 1519 - 1540

Published: April 28, 2022

Abstract The superior colliculus (SC), one of the most well-characterized midbrain sensorimotor structures where visual, auditory, and somatosensory information are integrated to initiate motor commands, is highly conserved across vertebrate evolution. Moreover, cell-type-specific SC neurons integrate afferent signals within local networks generate defined output related innate cognitive behaviors. This review focuses on recent progress in understanding phenotypic diversity amongst their intrinsic circuits long-projection targets. We further describe relevant neural specific cell types relation behavioral outputs functions. systematic delineation organization, types, connections put into context species as these depend upon laminar architecture. we focus circuitry involving saccadic eye movement, Overall, provides insight functioning represents a basis for pathology associated with dysfunction.

Language: Английский

Citations

56
High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons DOI Creative Commons
Jérémie Sibille, Carolin Gehr, Jonathan I. Benichov

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 5, 2022

Abstract The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors mammals. Neurons the receive inputs from retinal ganglion cells but how these are integrated vivo unknown. Here, we discovered high-density electrodes simultaneously capture activity of axons and their postsynaptic target neurons colliculus, vivo. We show cell mouse provide single precise representation retina as input to colliculus. This isomorphic mapping builds scaffold for retinotopic wiring functionally specific connection strength. Our methods broadly applicable, which demonstrate by recording optic tectum zebra finches. find common rules mice finches visual world encoded connections retinorecipient areas.

Language: Английский

Citations

53
A role for the claustrum in cognitive control DOI Creative Commons

Maxwell B. Madden,

Brent W. Stewart, Michael G. White

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(12), P. 1133 - 1152

Published: Sept. 30, 2022

Language: Английский

Citations

40
Mapping visual functions onto molecular cell types in the mouse superior colliculus DOI Creative Commons
Yuanming Liu, Élise Savier,

Victor J. DePiero

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(12), P. 1876 - 1886.e5

Published: April 21, 2023

The superficial superior colliculus (sSC) carries out diverse roles in visual processing and behaviors, but how these functions are delegated among collicular neurons remains unclear. Here, using single-cell transcriptomics, we identified 28 neuron subtypes subtype-enriched marker genes from tens of thousands adult mouse sSC neurons. We then asked whether the sSC's molecular tuned to different stimuli. Specifically, imaged calcium dynamics single vivo during stimulation mapped gene transcripts onto same ex vivo. Our results identify a subtype inhibitory accounting for ∼50% direction-selective cells, suggesting genetic logic functional organization sSC. In addition, our studies provide comprehensive atlas multimodal mapping method that will facilitate investigation their respective functions, connectivity, development.

Language: Английский

Citations

36
Defensive responses: behaviour, the brain and the body DOI
Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(11), P. 655 - 671

Published: Sept. 20, 2023

Language: Английский

Citations

35