Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 60, P. 115 - 121
Published: Dec. 19, 2019
Language: Английский
Annual Review of Vision Science, Journal Year: 2022, Volume and Issue: 8(1), P. 135 - 169
Published: April 6, 2022
Retinal circuits transform the pixel representation of photoreceptors into feature representations ganglion cells, whose axons transmit these to brain. Functional, morphological, and transcriptomic surveys have identified more than 40 retinal cell (RGC) types in mice. RGCs extract features varying complexity; some simply signal local differences brightness (i.e., luminance contrast), whereas others detect specific motion trajectories. To understand retina, we need know how give rise diverse RGC representations. A catalog set, turn, is fundamental understanding visual processing Anterograde tracing indicates that innervate 50 areas mouse Current maps connecting brain are rudimentary, as our signals transformed downstream guide behavior. In this article, I review selectivities RGCs, they arise, utilized downstream. Not only knowledge behavioral purpose critical for contributions vision; it can also us most relevant space.
Language: Английский
Citations
69
Cell Reports, Journal Year: 2022, Volume and Issue: 40(7), P. 111222 - 111222
Published: Aug. 1, 2022
Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, immediate avoidance. Yet little known about whether how multi-sensory cues are integrated conveyed each modality amygdala, a critical area perception learning. Here, we report neurons expressing calcitonin gene-related peptide (CGRP) in parvocellular subparafascicular nucleus thalamus external lateral parabrachial brainstem respond various negative valence central respectively. Both CGRP populations their amygdala projections required aversive memory formation. The identification unified may provide insights into developing therapeutic candidates fear-related disorders.
Language: Английский
Citations
62
Neuron, Journal Year: 2021, Volume and Issue: 109(23), P. 3810 - 3822.e9
Published: Oct. 5, 2021
Animals can choose to act upon, or ignore, sensory stimuli, depending on circumstance and prior knowledge. This flexibility is thought depend neural inhibition, through suppression of inappropriate disinhibition appropriate actions. Here, we identified the ventral lateral geniculate nucleus (vLGN), an inhibitory prethalamic area, as a critical node for control visually evoked defensive responses in mice. The activity vLGN projections medial superior colliculus (mSC) modulated by previous experience threatening tracks perceived threat level environment, low escape from visual threat. Optogenetic stimulation abolishes responses, suppressing its lowers threshold increases risk-avoidance behavior. most strongly affects potentially via modality-specific inhibition mSC circuits. Thus, circuits behavior, animal's anticipation danger environment.
Language: Английский
Citations
61
Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)
Published: June 10, 2021
Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful experiences precipitate depression and disrupt reward-seeking, but it remains unclear how stress causes anhedonia. We recorded simultaneous neural activity across limbic brain areas as mice underwent discovered stress-induced 4 Hz oscillation in the nucleus accumbens (NAc) that predicts degree subsequent blunted reward-seeking. Surprisingly, while previous studies on reward-seeking focused dopamine (DA) transmission from ventral tegmental area (VTA) to NAc, we found VTA GABA, not DA, neurons mediate Inhibiting GABA disrupts NAc oscillations rescues By contrast, mimicking this signature by stimulating NAc-projecting at reproduces both Finally, find encoding reward anticipation. Thus, elicits VTA-NAc GABAergic induces mediated
Language: Английский
Citations
59
Current Biology, Journal Year: 2021, Volume and Issue: 31(11), P. 2263 - 2273.e3
Published: April 2, 2021
Language: Английский
Citations
58
Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15
Published: Nov. 9, 2021
Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated use, social or lifestyle impairment, and risky use. Considerable efforts have been made to model features these criteria in non-human animal research subjects, for insight into underlying neurobiological mechanisms. Here we review evidence from rodent models SUD-inspired criteria, focusing on role striatal dopamine system. We identify distinct mesostriatal nigrostriatal circuit functions behavioral outcomes are relevant addictions SUDs. This work suggests essential not only positive SUDs, such elevated intake craving, but also impairments decision making underlie compulsive behavior, reduced sociality, risk taking. Understanding functional heterogeneity system related networks can offer this symptomatology may lead more targeted treatments.
Language: Английский
Citations
57
Neuron, Journal Year: 2022, Volume and Issue: 110(7), P. 1223 - 1239.e8
Published: Jan. 21, 2022
Language: Английский
Citations
57
Neuroscience Bulletin, Journal Year: 2022, Volume and Issue: 38(12), P. 1519 - 1540
Published: April 28, 2022
Abstract The superior colliculus (SC), one of the most well-characterized midbrain sensorimotor structures where visual, auditory, and somatosensory information are integrated to initiate motor commands, is highly conserved across vertebrate evolution. Moreover, cell-type-specific SC neurons integrate afferent signals within local networks generate defined output related innate cognitive behaviors. This review focuses on recent progress in understanding phenotypic diversity amongst their intrinsic circuits long-projection targets. We further describe relevant neural specific cell types relation behavioral outputs functions. systematic delineation organization, types, connections put into context species as these depend upon laminar architecture. we focus circuitry involving saccadic eye movement, Overall, provides insight functioning represents a basis for pathology associated with dysfunction.
Language: Английский
Citations
56
Current Biology, Journal Year: 2022, Volume and Issue: 32(13), P. 2834 - 2847.e5
Published: May 23, 2022
Language: Английский
Citations
45
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Feb. 10, 2022
Social behaviours characterize cooperative, mutualistic, aggressive or parental interactions that occur among conspecifics. Although the Ventral Tegmental Area (VTA) has been identified as a key substrate for social behaviours, input and output pathways dedicated to specific aspects of conspecific interaction remain understudied. Here, in male mice, we investigated activity function two distinct VTA inputs from superior colliculus (SC-VTA) medial prefrontal cortex (mPFC-VTA). We observed SC-VTA neurons display anticipatory calcium activity, which correlates with orienting responses towards an unfamiliar conspecific. In contrast, mPFC-VTA neuron population increases after initiation contact. While protracted phasic stimulation pathway promotes head/body movements decreases interaction, inhibition this interaction. found SC afferents mainly target subpopulation dorsolateral striatum (DLS)-projecting dopamine (DA) (VTADA-DLS). While, VTADA-DLS VTADA-Nucleus Accumbens it. Altogether, these data support model by at least largely anatomically sub-circuits oppositely control behaviour.
Language: Английский
Citations
43