Evolutionary convergence of sensory circuits in the pallium of amniotes

Science, Journal Year: 2025, Volume and Issue: 387(6735)

Published: Jan. 2, 2025

The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA spatial transcriptomics, mathematical modeling to compare the development evolution of known pallial across birds (chick), lizards (gecko), mammals (mouse). reveal neurons within these circuits’ stations generated at varying developmental times brain regions species found an early divergence in transcriptomic progression glutamatergic neurons. Our research highlights distinctions functional similarities circuit between mammals, suggesting convergence high-order processing lineages.

Language: Английский

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Shifting Developmental Trajectories During Critical Periods of Brain Formation

Frontiers in Cellular Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Sept. 10, 2020

Research on critical periods of brain development is greatly expanding our understanding the cellular and molecular mechanisms underlying epochs heightened plasticity driven by environmental influence. Novel studies have started to reveal that timely interventions during hold potential reorient abnormal developmental trajectories in animal models neurological neuropsychiatric disorders. In this review, we re-examine fundamental criteria characterize a period, highlighting recently discovered health disease. addition, touch upon technological improvements modelling human-derived neural networks vitro. These scientific advances associated with use manipulations immature represent promising new preclinical setting will allow future translatability into clinical applications for neurodevelopmental disorders such as intellectual disability, autism spectrum schizophrenia.

Language: Английский

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Mapping the molecular and cellular complexity of cortical malformations

Science, Journal Year: 2021, Volume and Issue: 371(6527)

Published: Jan. 21, 2021

The cerebral cortex is an intricate structure that controls human features such as language and cognition. Cortical functions rely on specialized neurons emerge during development from complex molecular cellular interactions. Neurodevelopmental disorders occur when one or several of these steps incorrectly executed. Although a number causal genes disease phenotypes have been identified, the sequence events linking disruption to clinical expression mostly remains obscure. Here, focusing malformations cortical development, we illustrate how interactions at genetic, cellular, circuit levels together contribute diversity variability in phenotypes. Using specific examples online resource, propose multilevel assessment processes key identifying points vulnerability developing new therapeutic strategies.

Language: Английский

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The enigmatic fetal subplate compartment forms an early tangential cortical nexus and provides the framework for construction of cortical connectivity

Progress in Neurobiology, Journal Year: 2020, Volume and Issue: 194, P. 101883 - 101883

Published: July 11, 2020

The most prominent transient compartment of the primate fetal cortex is deep, cell-sparse, synapse-containing subplate (SPC). developmental role SPC and its extraordinary size in humans remain enigmatic. This paper evaluates evidence on development connectivity discusses pathogenesis neurodevelopmental disorders. A synthesis data shows that becomes a by expansion from deep cortical plate (CP), appearing well-delineated MR scans forming tangential nexus across hemisphere, consisting an extracellular matrix, randomly distributed postmigratory neurons, multiple branches thalamic long corticocortical axons. generates early spontaneous non-synaptic synaptic activity mediates response upon stimulation. provides large-scale interareal possibly underlying fMR resting-state activity, before pathways are established. In late phase, when synapses appear within CP, coexists with permanent circuitry. histogenetic to provide interactive milieu capacity for guidance, sorting, "waiting" target selection thalamocortical pathways. new evolutionary remnant white matter neurons linked increasing number associative human neocortex. These roles attributed regulated using spatiotemporal gene expression during critical periods, pathogenic factors may disturb vulnerable circuitry SPC, causing cognitive

Language: Английский

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Advancing models of neural development with biomaterials

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(10), P. 593 - 615

Published: Aug. 10, 2021

Language: Английский

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