Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1 DOI
Pablo J. Lituma,

Evan Woo,

Bruce F. O’Hara

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(46)

Published: Nov. 10, 2021

Significance Abnormal microglia–neuron interaction is increasingly implicated in neurodevelopmental and neuropsychiatric conditions, such as autism spectrum disorders schizophrenia, well neurodegenerative disorders, Alzheimer’s disease. This study demonstrates that the deletion of microglia-specific protein Iba1, which has long been utilized a selective microglial marker but whose role remained unidentified, results structural functional impairments significantly impact synaptic development behavior. These findings not only highlight importance microglia brain function may also suggest modifying could provide therapeutic strategy for treatment neurodevelopmental, neuropsychiatric, disorders.

Language: Английский

Microglia: Immune and non-immune functions DOI
Katharina Borst, Anaëlle Dumas, Marco Prinz

et al.

Immunity, Journal Year: 2021, Volume and Issue: 54(10), P. 2194 - 2208

Published: Oct. 1, 2021

Language: Английский

Citations

454
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS DOI
Travis E. Faust, Georgia Gunner, Dorothy P. Schafer

et al.

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(11), P. 657 - 673

Published: Sept. 20, 2021

Language: Английский

Citations

266
GABA-receptive microglia selectively sculpt developing inhibitory circuits DOI Creative Commons
Emilia Favuzzi, Shuhan Huang, Giuseppe-Antonio Saldi

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(15), P. 4048 - 4063.e32

Published: July 1, 2021

Language: Английский

Citations

217
Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders DOI
Kristine E. Zengeler, John R. Lukens

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(7), P. 454 - 468

Published: Jan. 21, 2021

Language: Английский

Citations

188
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids DOI Creative Commons
Galina Popova, Sarah S. Soliman, Chang N. Kim

et al.

Cell stem cell, Journal Year: 2021, Volume and Issue: 28(12), P. 2153 - 2166.e6

Published: Sept. 17, 2021

Language: Английский

Citations

155
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity DOI Creative Commons
Matheus B. Victor,

Noelle Leary,

Xochitl Luna

et al.

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(8), P. 1197 - 1212.e8

Published: Aug. 1, 2022

Language: Английский

Citations

149
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques DOI Creative Commons
Ethan R. Roy,

Gabriel S. Chiu,

Sanming Li

et al.

Immunity, Journal Year: 2022, Volume and Issue: 55(5), P. 879 - 894.e6

Published: April 19, 2022

Language: Английский

Citations

135
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice DOI Creative Commons

Yohan S. S. Auguste,

Austin Ferro, Jessica A. Kahng

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(10), P. 1273 - 1278

Published: Sept. 28, 2022

Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited oligodendrogenesis. Here we show that contribute thalamocortical presynapse elimination in developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases response sensory experience during neural circuit refinement. Our data suggest may regulate synaptic connectivity brain independently

Language: Английский

Citations

103
Cytokines as emerging regulators of central nervous system synapses DOI Creative Commons
Frauke Zipp, Stefan Bittner, Dorothy P. Schafer

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(5), P. 914 - 925

Published: May 1, 2023

Language: Английский

Citations

85
Adolescence is a sensitive period for prefrontal microglia to act on cognitive development DOI Creative Commons
Sina M. Schalbetter,

Anina S. von Arx,

Natalia Cruz-Ochoa

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(9)

Published: March 2, 2022

The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive functions. One distinctive feature of the PFC its protracted adolescent maturation, which necessary for acquiring mature abilities in adulthood. Here, we show microglia, brain's resident immune cells, contribute to this maturational process. We find transient and cell-specific deficiency microglia adolescence sufficient induce an adult emergence PFC-associated impairments functions, dendritic complexity, synaptic structures. While also altered excitatory-inhibitory balance circuits, there were no sequelae when depleted Thus, our findings identify as sensitive period act on development.

Language: Английский

Citations

73