The mouse prefrontal cortex: Unity in diversity

Neuron, Journal Year: 2021, Volume and Issue: 109(12), P. 1925 - 1944

Published: April 23, 2021

Language: Английский

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Common principles for odour coding across vertebrates and invertebrates

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(7), P. 453 - 472

Published: May 28, 2024

Language: Английский

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Sexually dimorphic control of affective state processing and empathic behaviors

Neuron, Journal Year: 2024, Volume and Issue: 112(9), P. 1498 - 1517.e8

Published: March 1, 2024

Recognizing the affective states of social counterparts and responding appropriately fosters successful interactions. However, little is known about how are expressed perceived they influence decisions. Here, we show that male female mice emit distinct olfactory cues after experiencing distress. These activate neural circuits in piriform cortex (PiC) evoke sexually dimorphic empathic behaviors observers. Specifically, PiC → PrL pathway activated observers, inducing a preference for distressed counterpart. Conversely, MeA evoking excessive self-grooming behaviors. pathways originate from non-overlapping neuron populations with gene expression signatures regulated by transcription factors sex hormones. Our study unveils internal processed through mechanisms at molecular, cellular, circuit levels offers insights into underpinning differences higher brain functions.

Language: Английский

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Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 22, 2025

While animals readily adjust their behavior to adapt relevant changes in the environment, neural pathways enabling these remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from piriform cortex olfactory bulb supports such behavioral flexibility. To this end, engage head-fixed male mice a multimodal rule-reversal task guided by and auditory cues. Both odor and, surprisingly, sound cues trigger responses cortical bulbar axons which precede report. Responses same sensory cue are strongly modulated upon stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton occurs within seconds events is correlated with behavior. Optogenetic perturbation disrupts performance. Our results indicate that piriform-to-olfactory carry stimulus identity reward signals rapidly re-formatted according context. Hernandez-Trejo, Ciuparu, Garcia da Silva et al. report mouse carries signals, seconds,

Language: Английский

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Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations

Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 45(10), P. e1872242024 - e1872242024

Published: March 5, 2025

Sensory systems enable organisms to detect and respond environmental signals relevant for their survival reproduction. A crucial aspect of any sensory signal is its intensity; understanding how guide behavior requires probing system function across the range stimulus intensities naturally experienced by an organism. In olfaction, defining natural odorant concentrations difficult. Odors are complex mixtures airborne chemicals emitting from a source in irregular pattern that varies time space, necessitating specialized methods obtain accurate measurement concentration. Perhaps as result, experimentalists often choose based on empirical considerations rather than with respect ecological or behavioral context. Here, we attempt determine concentration ranges olfactory stimuli reviewing integrating data diverse disciplines. We compare used experimental studies rodents insects those reported different settings including ambient environments, headspace sources, within sources themselves. also these values psychophysical measurements detection threshold rodents, where thresholds have been extensively measured. Odorant regimes rarely exceed few parts per billion, while most investigating coding several orders magnitude. discuss implications this mismatch importance testing odorants neural mechanisms underlying sensation odor-guided behaviors.

Language: Английский

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Odor coding in piriform cortex: mechanistic insights into distributed coding

Current Opinion in Neurobiology, Journal Year: 2020, Volume and Issue: 64, P. 96 - 102

Published: May 16, 2020

Language: Английский

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Is the core function of orbitofrontal cortex to signal values or make predictions?

Current Opinion in Behavioral Sciences, Journal Year: 2021, Volume and Issue: 41, P. 1 - 9

Published: Feb. 25, 2021

Language: Английский

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A stable, distributed code for cue value in mouse cortex during reward learning

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Feb. 24, 2023

The ability to associate reward-predicting stimuli with adaptive behavior is frequently attributed the prefrontal cortex, but stimulus-specificity, spatial distribution, and stability of cue-reward associations are unresolved. We trained head-fixed mice on an olfactory Pavlovian conditioning task measured coding properties individual neurons across space (prefrontal, olfactory, motor cortices) time (multiple days). Neurons encoding cues or licks were most common in respectively. By quantifying responses cue-encoding six varying probabilities reward, we unexpectedly found value all regions sampled, some enrichment cortex. further that cue lick codes preserved days. Our results demonstrate stably encode components learning within a larger gradient properties.

Language: Английский

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Mechanisms of COVID‐19‐associated olfactory dysfunction

Neuropathology and Applied Neurobiology, Journal Year: 2024, Volume and Issue: 50(2)

Published: Feb. 28, 2024

Olfactory dysfunction is one of the most common symptoms COVID-19. In first 2 years pandemic, it was frequently reported, although its incidence has significantly decreased with emergence Omicron variant, which since become dominant viral strain. Nevertheless, many patients continue to suffer from persistent dysosmia and dysgeusia, making COVID-19-associated olfactory an ongoing health concern. The proposed pathogenic mechanisms are complex likely multifactorial. While evidence suggests that infection sustentacular cells associated mucosal inflammation may be culprit acute, transient smell loss, alterations in other components system (e.g., receptor neuron dysfunction, bulb injury cortex) lead persistent, long-term dysfunction. This review aims provide a comprehensive summary epidemiology, clinical manifestations current understanding

Language: Английский

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Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 2, 2024

Olfaction is influenced by contextual factors, past experiences, and the animal's internal state. Whether this information integrated at initial stages of cortical odour processing not known, nor how these signals may influence encoding. Here we revealed multiple diverse non-olfactory responses in primary olfactory (piriform) cortex (PCx), which dynamically enhance PCx discrimination according to behavioural demands. We performed recordings neurons from mice trained a virtual reality task associate odours with visual contexts obtain reward. found that learning shifts activity encoding solely regime positional, contextual, associative emerge on odour-responsive become mixed-selective. The modulation was dynamic, improving decoding during engagement rewarded contexts. This improvement relied acquired mixed-selectivity, demonstrating integrating extra-sensory inputs sensory cortices can while relevance stimuli.

Language: Английский

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