Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1175 - 1175
Published: Sept. 26, 2024
Aging
is
associated
with
increased
reactive
oxygen
species
(ROS)
and
reduced
bioavailability
of
nitric
oxide
(NO).
Curcumin
has
been
shown
to
increase
NO
due
its
ability
neutralize
ROS,
preventing
oxidative
stress.
The
present
study
aimed
investigate
the
effect
curcumin
intake
on
skeletal
muscle
parameters
exercise
tolerance
in
response
older
people.
Changes
circulating
levels
metabolites
were
also
investigated.
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 9, 2025
Nitric
oxide
(NO)
is
a
ubiquitous
signaling
molecule
known
to
modulate
various
physiological
processes,
with
specific
implications
in
skeletal
muscle
and
broader
applications
exercise
performance.
This
review
focuses
on
the
modulation
of
function,
mitochondrial
adaptation
redox
state
by
NO,
effect
nitrate
supplementation
In
NO
believed
increase
maximal
shortening
velocity
peak
power
output
fibers.
However,
its
submaximal
contraction
still
undetermined.
mitochondria,
may
stimulate
biogenesis
affect
respiratory
efficiency.
also
plays
role
within
muscle,
partially
through
interaction
chain
enzymes
transcriptional
regulators
antioxidant
production.
Nitrate
leads
an
increased
bioavailability
muscle.
Thus,
has
been
investigated
for
ability
impact
performance
outcomes
endurance
resistance
exercise.
The
currently
indecisive,
although
evidence
indicates
that
it
extend
time
exhaustion
Alternatively,
less
studied.
Limited
research
improve
repetitions
failure.
Further
needed
investigate
influence
training
status,
age,
sex,
duration
further
elucidate
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Oct. 17, 2023
Aging
is
the
basis
for
several
unfavorable
conditions,
including
cardiovascular
diseases
(CVDs).
In
this
sense,
regular
physical
activity
(regular
PA)
has
been
proven
to
delay
cellular
aging
and
prevent
endothelial
dysfunction
related
CVDs.
Despite
numerous
studies
involving
athletes,
little
known
about
molecular
mechanisms
of
PA
among
master
athletes.
The
present
study
aimed
at
evaluating
effects
on
local
microcirculatory
functions
in
elderly
athletes
as
compared
age-matched
sedentary
controls.
Moreover,
molecular/epigenetic
(nitric
oxide,
oxidative
stress,
PGC-1α,
SIRT1
miR29)
were
also
assessed.
results
showed
that
significantly
increased
blood
flow
post-ischemia
post-heating
well
NO
plasma
concentrations,
denoting
a
better
function/microcirculatory
efficiency.
presented
greater
antioxidant
transcriptional
levels
metabolism
regulator
PGC-1α.
Finally,
enhanced
level
miR29,
suggested
epigenetic
regulators
redox
balance
metabolism.
addition,
stimulated
was
directly
capacity,
miR29
levels.
Overall,
our
data
confirm
beneficial
profile
shed
light
signals
involved
positive
adaptations
exercise.
ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
7(16), P. 18590 - 18609
Published: Oct. 20, 2023
The
free
radical
nitric
oxide
(NO)
is
a
signaling
molecule
that
controls
several
important
physiological
and
pathophysiological
processes
in
mammals
plants.
In
humans,
the
biological
impacts
of
NO
include,
but
are
not
limited
to,
key
roles
cardiovascular,
neurological,
immunological,
respiratory,
reproductive
systems.
plants,
modulates
plant
growth
development
with
defense
against
biotic
abiotic
stress
conditions.
However,
administration
exogenous
donors
still
faces
limitations,
mainly
due
to
their
instability
lack
bioavailability
system.
Recently,
combination
nanomaterials
has
been
extensively
explored
as
promising
strategy
tailor
spatiotemporal
release
therapeutic
amounts
NO.
Nanoscience
offers
smart
approaches
deliver
on
demand
for
particular
application.
Although
this
shown
results,
scientific
studies
less
agricultural
applications
compared
biomedical
research.
current
review
summarizes
impact
research
emphasizes
recent
progress
nanotechnology
donors.
advantages,
challenges,
drawbacks
discussed
light
inspiring
exciting
topic,
aiming
translate
these
innovations
into
clinical/practical
settings.
Reviews in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
26(2)
Published: Feb. 20, 2025
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
death
worldwide,
with
physical
inactivity
being
a
known
contributor
to
global
rates
CVD
incidence.
incidence,
however,
not
uniform
recognized
sex
differences
as
well
and
racial
ethnic
differences.
Furthermore,
gut
microbiota
have
been
associated
CVD,
sex,
race/ethnicity.
Researchers
begun
examine
interplay
these
complicated
yet
interrelated
topics.
This
review
will
present
evidence
that
(risk
development),
are
distinct
between
sexes
racial/ethnic
groups,
which
appear
be
influenced
by
acculturation,
discrimination,
stress,
lifestyle
factors
like
exercise.
this
address
beneficial
impacts
exercise
on
cardiovascular
system
provide
recommendations
for
future
research
in
field.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(5), P. 903 - 903
Published: March 5, 2025
Introduction:
The
assessment
of
cardiovascular
risk
has
traditionally
relied
on
validated
scales
designed
to
estimate
the
likelihood
experiencing
a
event
within
specific
timeframe.
In
recent
years,
novel
methodologies
have
emerged,
offering
more
objective
evaluation
this
through
indicators
such
as
vascular
age
(VA)
and
heart
(HA).
Objective:
This
study
aimed
investigate
relationship
between
sociodemographic
factors,
lifestyle
behaviors,
their
impact
VA
HA.
Materials
Methods:
A
dual
design,
encompassing
both
cross-sectional
longitudinal
retrospective
approaches,
was
conducted
among
cohort
employees.
variables
assessed
included
characteristics
(age,
sex,
socioeconomic
status)
health-related
habits
(smoking,
physical
activity,
adherence
Mediterranean
diet,
alcohol
consumption).
Results:
findings
revealed
that
all
analyzed
were
significantly
associated
with
elevated
HA
values.
Among
these,
demonstrated
strongest
association,
odds
ratios
(OR)
114.91
(95%
CI:
100.45-131.43)
for
high
34.48
31.41-37.56)
VA.
Conclusions:
profile
individuals
most
at
encompasses
males
advanced
age,
characterized
by
low
status,
sedentary
lifestyle,
poor
regular
consumption.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(3), P. e0316383 - e0316383
Published: March 13, 2025
Hypertension
in
the
elderly
can
seriously
lead
to
cerebral
microvascular
damage
and
promote
development
of
vascular
cognitive
impairment.
While
endothelial
function
is
crucial
protection,
it
unclear
whether
aging
exacerbates
hypertension-induced
dysfunction
through
dysfunction.
In
this
study,
we
injected
D-galactose
(D-gal)
into
24
spontaneous
hypertension
rats
(SHR)
Wistar-Kyoto
(WKY)
for
12
weeks
induce
aging.
Firstly,
results
behavioral
experiments
showed
that
compared
with
WKY
SHRs
D-gal
0
week,
had
more
severe
memory
Subsequently,
pathological
changes
brain
microvessels
their
structural
functional
were
significant.
After
that,
molecular
enormous
indicators
(nitric
oxide
(NO),
endothelin
(ET-1),
platelet
cell
adhesion
molecule-1(CD31)
tight
junction
protein),
aggravation
blood-brain
barrier
(BBB)
damage,
microglial
activation
upregulation
pro-inflammatory
cytokines.
Ultimately,
combination
treatment
nimodipine
butylphthalide
two
drugs
could
hugely
improve
SHRs.
summary,
elaborated
SHRs,
which
may
be
due
dysfunction,
even
BBB
neuroinflammation,
while
providing
a
theoretical
basis
hypertension-related
diseases.
