Association between High-Sensitivity C-Reactive Protein and Metabolic Syndrome and Its Components in Older Adults: Findings from Neyshabur Longitudinal Study on Ageing (NeLSA)

Clinical Diabetology, Journal Year: 2024, Volume and Issue: 1(1), P. 52 - 59

Published: March 1, 2024

Objective: To evaluate the association between highsensitivity C-reactive protein (hsCRP) and metabolic syndrome (MetS), components of MetS as well diabetes, cardiovascular complications. Materials methods: In this cross-sectional analysis, data were collected from registration phase Neyshabur Longitudinal Study on Ageing (NeLSA) comprising a total 6034 people aged 50 older. Association hsCRP its was conducted by univariate multivariate analyses in presence covariates confounding factors. Results: Baseline including age, body fat mass, mass index, waist-to-hip ratio, fasting plasma glucose, triglyceride, creatinine, albumin, also systolic blood pressure, diastolic pressure higher group compared to control (p < 0.001 for all variables other than hsCRP, which not significant = 0.06)). Also multi variate analysis illustrated one-unit increase serum level associated with 18% risk diabetes [OR: 1.18; 95% confidence interval (CI), 1.06–1.30] increased high-density lipoprotein cholesterol (HDL-C) 15% (OR:1.15; (95% CI, 1.01–1.29). subjects MetS, (log 1 mg/L) 34% atherosclerotic disease (ASCVD) (OR: 1.34; 1.11–1.63). Conclusions: There is an HDL-C especially women.

Language: Английский

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The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 4139 - 4139

Published: Nov. 19, 2021

We analyzed the effectiveness of two nutritional interventions alone and together, EVOO DieTBra, on inflammatory profile severely obese individuals. This study was an RCT with 149 individuals aged from 18 to 65 years, a body mass index ≥ 35 kg/m

Language: Английский

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Vitamin D in women with class II/III obesity: Findings from the DieTBra trial

Clinical Nutrition ESPEN, Journal Year: 2023, Volume and Issue: 55, P. 83 - 89

Published: March 9, 2023

ObjectiveTo assess the prevalence of vitamin D deficiency and factors associated with serum levels in adult women class II/III obesity.MethodsWe analysed baseline data from 128 obesity i.e. BMI ≥35 kg/m2 who participated DieTBra clinical trial. Sociodemographic, lifestyle, sun exposure, sunscreen, dietary intake calcium D, menopause, diseases, medication, body composition were using multiple linear regression.Results128 had mean 45.53 ± 6.36, age 39.7 8.75 30.02 ng/ml 9.80. Vitamin was 14.01%. There no association between BMI, fat percentage, total waist circumference. Age group (p = 0.004), exposure/day 0.072), use sunscreen 0.168), inadequate 0.030), 0.192), menopause 0.029) lipid-lowering drugs 0.150) included regression. The following remained low D: being 40–49 years 0.003); ≥50 0.020) 0.027).ConclusionThe lower than expected. Lifestyle, exposure not associated. over 40 significantly levels.

Language: Английский

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Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2021, Volume and Issue: Volume 14, P. 3733 - 3742

Published: Aug. 1, 2021

Either visceral fat or muscle mass is identified to be correlated with cardiometabolic diseases, especially in type 2 diabetes (T2DM). But, the synergistical effect of along skeletal on risk cardiovascular diseases (CVD) T2DM still remains controversial. Thus, we investigated relationship between area ratio (SVR) and 10-yr CVD scores.A total 291 patients aged 40-80 years were enrolled current study. SVR was evaluated based bioelectrical impedance measurements. Both Framingham score system China-PAR model applied estimate future population.The scores increased decreased tertiles (All P<0.001). value obviously lower high-risk group than that low- moderate-risk P<0.05). However, no significant differences observed BMI among different groups. Besides, (r=-0.408; P<0.001) (r=-0.336; HOMA-IR, triglycerides blood pressure also inversely related Furthermore, independently both (β=-0.074, P=0.047) (β=-0.100, P=0.004) after adjustment for confounding factors, including age, gender, BMI, FPG, HbA1c, duration, albumin, creatinine, uric acid, smoking, lipid. The linear regression analysis conducted men women, respectively, indicating negative but not women.T2DM populations who have are more likely increase risk. levels show marked inverse correlation estimated T2DM, could a valuable parameter assess events clinical practice, men.

Language: Английский

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Positive Effects of Extra-Virgin Olive Oil Supplementation and DietBra on Inflammation and Glycemic Profiles in Adults With Type 2 Diabetes and Class II/III Obesity: A Randomized Clinical Trial

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: May 2, 2022

Background Evidence on the effects of dietary interventions inflammatory markers in individuals with obesity and type 2 diabetes mellitus (T2DM) is scarce. Our study evaluated extra-virgin olive oil alone combination a traditional Brazilian diet glycemic profiles adults both T2DM class II/III obesity. Methods Adults aged 18-64 years were randomized into two intervention groups: 1) only 2) + (OliveOil+DietBra). Data sociodemographic characteristics, lifestyle, anthropometry, biochemical collected. The primary outcomes parameters markers. body mass index (BMI) weight secondary outcomes. Results Forty enrolled, 34 (85%) completed course. intake was 37.88 ± 12.50 mL/day group 37.71 12.23 OliveOil+DietBra group, no significant difference between groups (p = 0.484). Compared to had significantly lower levels fasting insulin 0.047) at end intervention, whereas other not altered. In serum cytokines, IL-1α 0.006) adiponectin 0.049) those TNFα higher 0.037). There reduction BMI compared baseline values 0.015). Conclusions effectively decreased insulin, adiponectin, suggesting its beneficial role improving T2DM. Clinical Trial Registration ClinicalTrials.gov , identifier: NCT02463435

Language: Английский

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Association of Pain, Severe Pain, and Multisite Pain with the Level of Physical Activity and Sedentary Behavior in Severely Obese Adults: Baseline Data from the DieTBra Trial

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(12), P. 4478 - 4478

Published: June 22, 2020

The study aimed to assess the prevalence of pain, severe and pain in four or more regions associated with physical activity sedentary behavior, as well other factors severely obese adults (Body Mass Index ≥ 35 kg/m2). Baseline data from DieTBra Trial were analyzed. outcome variables (yes/no) sites (yes/no), identified by Brazilian version Nordic Musculoskeletal Questionnaire, along presence based on Numerical Pain Rating Scale (≥8). main independent moderate vigorous (MVPA), light activity, assessed triaxial accelerometry. analyzed using multiple hierarchical Poisson regression. In 150 individuals (men, 14.67%; women, 85.33%), a mean age 39.6 ± 0.7 years, there was high (89.33%), (69.33%), (53.33%). shorter MVPA time (p = 0.010); arthritis/arthrosis 0.007) use muscle relaxants 0.026) pain; economic class C 0.033), D 0.003), arthritis arthrosis 0.025) sites. There no significant associations between behavior any three outcomes These findings indicate that, individuals, is higher pain. Future studies intervention may contribute reduction severity obesity.

Language: Английский

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What are the factors associated with sarcopenia-related variables in adult women with severe obesity?

Archives of Public Health, Journal Year: 2020, Volume and Issue: 78(1)

Published: Aug. 3, 2020

Abstract Background Understanding the association between sarcopenia-related variables and several risk factors may help to implement interventions aimed at preventing its occurrence by reducing or controlling identified factors. Although changes in body composition occur both sexes, women, muscle loss is accentuated due decreased estrogen levels following menopause. This study aims determine associated with parameters middle-aged women class II/III obesity (body mass index [BMI] ≥ 35 kg/m 2 ). Methods The included 104 severe (40.23 ± 8.49 years) an average fat percentage of 52.45 4.14%. Sarcopenia was assessed using total appendicular skeletal (ASMM), (ASMMI), adjusted BMI (ASMM/BMI) as evaluated dual energy X-ray absorptiometry (DXA). Hand grip strength (HGS) HGS (HGS/BMI) were dynamometry. Functional performance walking speed test (WS). explanatory age, lifestyle, comorbidities, food consumption, metabolic parameters. A multivariate linear regression performed. Results Factors severely obese a mean 43.85 follows: ASMMI negatively correlated serum tetraiodothyronine (T4) tobacco use; ASMM/BMI T4 levels, diabetes; ASMM age hypercholesterolemia, positively low-density lipoprotein cholesterol (LDL-c); HGS/BMI hypercholesterolemia LDL-c; WS hypothyroidism diabetes. Conclusion In function inversely smoking status, endocrine parameters, comorbidities such Thus, results this investigation are relevant supporting development clinical aid prevention sarcopenia adult obesity.

Language: Английский

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Prevalence of Adverse Drug Events in Severely Obese Adults and Associated Factors: Clinical Trial Baseline Results

Scientia Pharmaceutica, Journal Year: 2020, Volume and Issue: 88(4), P. 41 - 41

Published: Sept. 23, 2020

Drugs are the most widely used therapeutic tool for treatment of diseases. However, misuse can lead to an adverse drug event (ADE) in susceptible individuals such as those that severely obese. This study aimed describe frequency ADEs, associations ADEs with anatomical chemical classes and their respective frequency, estimate prevalence analyse factors associated ADE adults severe obesity. Cross-sectional analysis baseline data from a randomized clinical trial central-western region Brazil. A total 150 aged 18–65 years Body Mass Index 35 kg/m2 were included. The outcome variable was presence explanatory variables socio-demographic factors, lifestyle, health, medication use. use drugs digestive tract metabolism (p < 0.001) cardiovascular system 0.001). 32.67% (n = 49) age range 40 49 0.033), diabetes 0.004), multimorbidities ≥ 4 0.009), self-medication (0.031), potential interactions (0.017). high commonly obesity-related morbidities self-medication. introduction pharmacist multi-professional teams improve safety obese patients.

Language: Английский

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Identification of the Framingham Risk Score by an Entropy-Based Rule Model for Cardiovascular Disease

Entropy, Journal Year: 2020, Volume and Issue: 22(12), P. 1406 - 1406

Published: Dec. 13, 2020

Since 2001, cardiovascular disease (CVD) has had the second-highest mortality rate, about 15,700 people per year, in Taiwan. It thus imposed a substantial burden on medical resources. This study was triggered by following three factors. First, CVD problem reflects an urgent issue. A high priority been placed long-term therapy and prevention to reduce wastage of resources, particularly developed countries. Second, from perspective preventive medicine, popular data-mining methods have well learned studied, with excellent performance fields. Thus, identification risk factors using these techniques is prime concern. Third, Framingham score core indicator that can be used establish effective prediction model accurately diagnose CVD. this proposes integrated predictive organize five notable classifiers: rough set (RS), decision tree (DT), random forest (RF), multilayer perceptron (MLP), support vector machine (SVM), novel use for attribute selection (i.e., F-attributes first identified study) determine key features identifying Verification experiments were conducted evaluation criteria—accuracy, sensitivity, specificity—based 1190 instances dataset available Taiwan teaching hospital 2019 examples public dataset. Given empirical results, SVM showed best terms accuracy (99.67%), sensitivity (99.93%), specificity (99.71%) all compared other listed classifiers. The RS highest (85.11%), (86.06%), (85.19%) most above results evidence no classifier or suitable practical datasets applications. appropriate address specific data important. Significantly, its calculation attributes DT technique produce entropy-based rules knowledge sets, which not undertaken previous research. conclusively yielded meaningful knowledgeable structures contributed differentiation classifiers two useful research findings helpful management implications subsequent In particular, provide reasonable solutions simplify processes medicine standardizing formats codes problems. significant those past

Language: Английский

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Potential of four definitions of metabolic syndrome to discriminate individuals with different 10-year cardiovascular disease risk scores: a cross-sectional analysis of an Iranian cohort

BMJ Open, Journal Year: 2022, Volume and Issue: 12(2), P. e058333 - e058333

Published: Feb. 1, 2022

We aimed to reveal the potential of four different metabolic syndrome (Mets) definitions differentiate subjects according 10-year risk cardiovascular disease. A cross-sectional analysis a prospective cohort. This study used baseline data from Shiraz Heart Study, cohort in Shiraz, Iran. Participants were screened against Mets including modified WHO, National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), American Association (AHA) and International Diabetes Federation (IDF). Also, Framingham score (FRS) atherosclerotic disease (ASCVD) determined for each participant. total number 7225 participants both genders entered study. They selected through defined family physician centres geographical areas. Urban residents with no migration plan included. Those who far or disabilities that made them incapable cooperate excluded. 47.68% (N=3445) male mean age 52.13±8.00 years. The identified by WHO was lowest (N=1676), while percentage high highest, 17.1% (N=282) FRS 9.8% (N=162) ASCVD score. There statistically significant differences scores between without AHA, NCEP (p<0.001). In IDF definition, not compared peers Mets, neither based on (p=0.247) nor (p=0.193). appropriate definition discrimination and/or those at future events. effective discriminate Mets.

Language: Английский

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