Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: July 20, 2024
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
209, P. 107434 - 107434
Published: Sept. 25, 2024
Mitochondria
are
crucial
organelles
that
regulate
cellular
energy
metabolism,
calcium
homeostasis,
and
oxidative
stress
responses,
playing
pivotal
roles
in
brain
development
neurodegeneration.
Concurrently,
the
gut
microbiota
has
emerged
as
a
key
modulator
of
physiology
pathology
through
microbiota-gut-brain
axis.
Recent
evidence
suggests
an
intricate
crosstalk
between
mitochondrial
function,
mediated
by
microbial
metabolites
can
influence
activities
brain.
This
review
aims
to
provide
comprehensive
overview
emerging
role
mitochondria
critical
mediators
axis,
shaping
health
neurological
disease
pathogenesis.
We
discuss
how
such
short-chain
fatty
acids,
secondary
bile
tryptophan
metabolites,
trimethylamine
N-oxide
traverse
blood-brain
barrier
modulate
processes
including
production,
regulation,
mitophagy,
neurons
glial
cells.
Additionally,
we
proposed
targeting
diet,
prebiotics,
probiotics,
or
promising
potential
therapeutic
approach
maintain
optimizing
fitness.
Overall,
further
investigations
into
its
bioenergetics,
dynamics,
responses
will
valuable
insights
axis
both
states.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 16, 2024
Preclinical
evidence
has
firmly
established
a
bidirectional
interaction
among
the
lung,
gut,
and
gut
microbiome.
There
are
many
complex
communication
pathways
between
lung
intestine,
which
affect
each
other's
balance.
Some
metabolites
produced
by
intestinal
microorganisms,
immune
cells,
factors
enter
tissue
through
blood
circulation
participate
in
function.
Altered
gut-lung-microbiome
interactions
have
been
identified
rodent
models
humans
of
several
diseases
such
as
pulmonary
fibrosis,
chronic
obstructive
disease,
cancer,
asthma,
etc.
Emerging
suggests
that
microbial
therapies
can
prevent
treat
respiratory
diseases,
but
it
is
unclear
whether
this
association
simple
correlation
with
pathological
mechanisms
disease
or
result
causation.
In
review,
we
summarize
critical
link
microbiota
well
influence
mechanism
on
discuss
role
interventions
prebiotics
fecal
bacteria
transplantation
diseases.
To
provide
reference
for
rational
design
large-scale
clinical
studies,
direct
application
therapy
to
respiratory-related
reduce
incidence
severity
accompanying
complications.
Therapeutic Advances in Neurological Disorders,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 1, 2025
Background:
Amyotrophic
lateral
sclerosis
(ALS)
is
a
rapidly
progressing
and
rare
neurodegenerative
disease.
Therefore,
evaluating
the
risk
factors
affecting
survival
of
patients
with
ALS
crucial.
Constipation,
common
but
overlooked
symptom
ALS,
can
be
effectively
managed.
It
currently
unknown
whether
constipation
contributes
to
progression
ALS.
Objectives:
This
study
aimed
investigate
association
between
development
using
novel
overlap-weighted
(OW)
method
enhance
robustness
reliability
results.
Design:
prospective
matching
nested
case-control
(NCC)
was
conducted
within
an
ongoing
cohort
at
Second
Hospital
Hebei
Medical
University.
Baseline
data
were
collected
from
meeting
inclusion
exclusion
criteria,
as
exposure
factor.
A
9-month
follow-up
conducted,
death
endpoint
event.
Methods:
We
primarily
used
OW
in
NCC
studies
examine
survival.
Weighted
Cox
proportional
hazards
model
assess
associated
overall
Survival
differences
two
groups
analyzed
Kaplan-Meier’s
plots
log-rank
tests.
Finally,
bioinformatic
analysis
explored
pathways
constipation.
Results:
Among
190
included,
prevalence
50%.
Patients
exhibited
faster
disease
(
p
<
0.001),
positive
correlation
severity
rate
r
=
0.356,
0.001).
The
group
had
poorer
before
after
(log-rank
test,
0.0001).
In
114
patients,
factor
for
both
(hazard
ratio
(HR)
5.840,
95%
confidence
interval
(CI)
1.504–22.675,
0.011)
(HR
5.271,
CI
1.241–22.379,
0.024)
OW.
Conclusion:
Constipation
individuals
reduced
rates,
potentially
through
peroxisome
proliferator-activated
receptor
pathway.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
