Lab on chip with green miniaturized technologies DOI
Chaudhery Ghazanfar Hussain, Rüstem Keçili, Chaudhery Mustansar Hussain

et al.

Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Macrophage polarization and its impact on idiopathic pulmonary fibrosis DOI Creative Commons

Zhouling Ge,

Yong Q. Chen,

Leikai Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing in the lungs and ultimately resulting respiratory failure high risk of death. Macrophages play crucial role immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, impacting development IPF. Recent research has indicated polarization onset progression M1 secrete inflammatory cytokines agents early damage fibrosis, while M2 support tissue healing releasing cytokines. Developing novel treatments for IPF relies on thorough comprehension processes involved macrophage The review outlines regulation its impact IPF, with goal investigating possible therapeutic benefits advancement

Language: Английский

Citations

12
Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies DOI
Manoj Kumar Gupta,

Gayatri Gouda,

Ramakrishna Vadde

et al.

Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 475 - 495

Published: June 8, 2024

Language: Английский

Citations

3
Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy DOI Creative Commons

Ruiming Han,

Dongdong Zhu,

Jichao Sha

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 4, 2024

Abstract Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass significant category IgE-mediated atopic disorders, including asthma, allergic rhinitis, dermatitis, food allergies. These complex conditions arise from the intricate interplay between genetic environmental factors are known to contribute socioeconomic burdens globally. Recent advancements in study diseases have illuminated crucial role DNA methylation (DNAm) their pathogenesis. This review explores influencing DNAm delves into mechanisms, offering valuable perspectives for clinicians. Understanding these epigenetic modifications aims lay groundwork improved early prevention strategies. Moreover, our analysis mechanisms seeks enhance diagnostic therapeutic approaches, paving way more effective management future.

Language: Английский

Citations

3
Epigenetic Reprogramming Mediates Monocyte and Heterologous T Cell-derived Cytokine Responses after BCG Vaccination DOI Open Access
Cancan Qi, Zhaoli Liu, Gizem Kılıç

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract Epigenetic reprogramming plays an important role in shaping immune memory traits within both innate (trained immunity) and adaptive cells following Bacillus Calmette-Guérin (BCG) vaccination. However, the precise impact of dynamic DNA methylation alterations on immunological responses after BCG vaccination remains inadequately elucidated. To address this knowledge gap, we conducted a comprehensive study by integrating longitudinal analysis systems biology approaches. We established cohort 284 healthy Dutch individuals, capturing data genetics, cytokine to ex vivo stimulation genome-wide at baseline, as well 14 days 90 Our findings revealed distinct patterns alternations short- long-term Moreover, that baseline profiles exert influence change interferon-γ (IFN-γ) production upon heterologous ( Staphylococcus aureus) before Specifically, identified regulation kisspeptin novel pathway implicated modulation IFN-γ production, finding has been substantiated through experiment validation. also observed associations between BCG-induced changes increased Interleukin-1 β (IL-1β) S. aureus stimulation. Interestingly, with genetic, epigenetic, response from same mediation demonstrated most played mediating genetic variants responses, for example, cg21375332 near SLC12A3 gene mediated Sex-specific effects consistently manifested association responses. Together, our provide deeper insights into mechanisms, crucial developing effective epigenetic-based medical interventions personalized medicine.

Language: Английский

Citations

2
Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells DOI Creative Commons
Chengxiong Huang,

Liming Qing,

Xiao Yu

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 14(1), P. 4 - 4

Published: Dec. 20, 2023

Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease, which one causes hip pain and dysfunction. ONFH has very high disability rate, associated with heavy burden to patients, families, society. The pathogenesis not completely clear. At present, it believed that mainly includes coagulation dysfunction, abnormal lipid metabolism, an imbalance osteogenic/adipogenic differentiation, poor vascularization repair. prevention treatment always been great challenge for clinical surgeons. However, recent studies have emphasized use mesenchymal stem cells (MSCs) treat steroid-induced (SONFH) promising therapy. This review focuses on role molecular mechanism epigenetic regulation in progress MSCs SONFH, discusses significance latest research SONFH from perspective epigenetics.

Language: Английский

Citations

6
Deciphering the role of FOXP4 in long COVID: exploring genetic associations, evolutionary conservation, and drug identification through bioinformatics analysis DOI
Manoj Kumar Gupta,

Gayatri Gouda,

Ramakrishna Vadde

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Sept. 19, 2024

Language: Английский

Citations

1
Sex-specific epigenetic signatures of circulating urate and its increase after BCG vaccination DOI Creative Commons
Cheng‐Jian Xu, Zhaoli Liu, Tania O. Crişan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Abstract Background: Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion serum variance, mediate genetic effect on concentration, co-regulate with cardiometabolic traits. However, whether is associated in sex-dependent manner unknown. Additionally, it worth investigating if changes after perturbations, such as vaccination, are sex-specific manner. Methods: We investigated association between concentrations Dutch cohort 325 healthy individuals. were measured before Bacillus Calmette-Guérin (BCG) used perturbation increased gout flares. The analysis included united, interaction, sex-stratified analysis. Validation identified CpG sites was conducted using three independent cohorts. Results: 215 males, while 5 females, indicating associations. Circulating significantly BCG baseline differences vaccination males enriched neuro-protection pathways, whereas change-associated related lipid glucose metabolism. Conclusion: Our study enhances understanding how epigenetic factors contribute regulating levels These insights have significant implications for diagnosis, prevention, treatment various urate-related diseases highlight importance personalized approaches medicine.

Language: Английский

Citations

0
Lab on chip with green miniaturized technologies DOI
Chaudhery Ghazanfar Hussain, Rüstem Keçili, Chaudhery Mustansar Hussain

et al.

Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0