Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1845 - 1845

Published: Feb. 15, 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical medicinal sections to promote human health prevent cure different diseases. The most common found nature anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, other sub-classes. impacts of plant phenolics on promoting diseases curing preventing antioxidant effects, antibacterial impacts, cardioprotective anticancer immune system promoting, anti-inflammatory skin protective effects from UV radiation. This work aims provide an overview phenolic as important sources medical application according recently published studies, well some interesting directions future research. keyword searches flavonoids, phenolics, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, secoiridoids were performed by using Web Science, Scopus, Google scholar, PubMed. acids contain a carboxylic acid group addition the basic structure mainly divided into hydroxybenzoic hydroxycinnamic acids. Hydroxybenzoic based C6-C1 skeleton often bound small organic acids, glycosyl moieties, or cell structural components. Common include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, salicylic Hydroxycinnamic C6-C3 also molecules such quinic glucose. main caffeic, p-coumaric, ferulic, sinapic

Language: Английский

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Dietary Anti-Aging Polyphenols and Potential Mechanisms

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 283 - 283

Published: Feb. 13, 2021

For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, decreasing morbidities. With assistance basic research investigating potential mechanisms, it become clear that beneficial effects plant-based foods are mainly due to large amount bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies humans have supported supplementation polyphenols various health-promoting effects, especially elderly population. In vitro examinations on anti-aging mechanisms widely performed, using different types natural synthetic compounds. The aim this review is critically evaluate experimental evidence demonstrating aging-related diseases. We highlight polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, promoting mitochondrial function. While trends utilizing disorders getting growing attention, we suggest exploration combination multiple or polyphenol-rich foods, as would be more physiologically relevant daily life.

Language: Английский

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Dietary Phenolic Compounds: Their Health Benefits and Association with the Gut Microbiota

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 880 - 880

Published: April 4, 2023

Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while antioxidants in foods may prevent a number of diseases delay aging by exerting their effects vivo. Phenolic compounds are phytochemicals flavonoids which consist flavonols, flavones, flavanonols, flavanones, anthocyanidins, isoflavones, lignans, stilbenoids, curcuminoids, phenolic acids, tannins. They have hydroxyl groups molecular structures. These present most plants, abundant nature, contribute to the bitterness color foods. Dietary compounds, quercetin onions sesamin sesame, exhibit antioxidant activity help cell diseases. In addition, other kinds tannins, larger weights, many unexplained aspects still exist. The activities be beneficial for human health. On hand, metabolism intestinal bacteria changes structures these with properties, resulting metabolites exert recent years, it has become possible analyze composition microbiota. augmentation microbiota intake been implicated disease prevention symptom recovery. Furthermore, "brain-gut axis", is communication system between gut microbiome brain, attracting increasing attention, research revealed that dietary affect brain homeostasis. this review, we discuss usefulness against some biotransformation microbiota, microflora, on brain-gut axis.

Language: Английский

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Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 2, 2024

Oxidative stress is a biochemical process that disrupts the redox balance due to an excess of oxidized substances within cell. closely associated with multitude diseases and health issues, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, inflammatory conditions, aging. Therefore, developing antioxidant treatment strategies has emerged as pivotal area medical research. Hydrogels have garnered considerable attention their exceptional biocompatibility, adjustable physicochemical properties, capabilities for drug delivery. Numerous hydrogels been developed proven effective in alleviating oxidative stress. In pursuit more treatments stress-related there urgent need advanced fabrication multifunctional hydrogels. Consequently, authors' focus will be on possess reactive oxygen species nitrogen scavenging capabilities, role therapy evaluated. Herein, mechanisms design applications are discussed systematically order provide critical insights further advancements field.

Language: Английский

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Comprehensive review on patulin and Alternaria toxins in fruit and derived products

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: April 3, 2023

Mycotoxins are toxic secondary metabolites produced by certain fungi, which can contaminate various food commodities, including fruits and their derived products. Patulin Alternaria toxins among the most commonly encountered mycotoxins in fruit In this review, sources, toxicity, regulations related to these mycotoxins, as well detection mitigation strategies widely discussed. is a mycotoxin mainly fungal genera Penicillium , Aspergillus Byssochlamys . toxins, fungi genus, another common group of found The prevalent alternariol (AOH) monomethyl ether (AME). These concern due potential negative effects on human health. Ingesting contaminated with cause acute chronic health problems. Detection patulin products be challenging low concentrations complexity matrices. Common analytical methods, good agricultural practices, contamination monitoring important for safe consumption And Future research will continue explore new methods detecting managing ultimate goal ensuring safety quality product supply.

Language: Английский

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The Potential of Ginkgo biloba as a Source of Biologically Active Compounds—A Review of the Recent Literature and Patents

Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 3993 - 3993

Published: May 9, 2023

is a relict tree species showing high resistance to adverse biotic and abiotic environmental factors. Its fruits leaves have medicinal value due the presence of flavonoids, terpene trilactones phenolic compounds. However, ginkgo seeds contain toxic allergenic alkylphenols. The publication revises latest research results (mainly from 2018-2022) regarding chemical composition extracts obtained this plant provides information on use or their selected ingredients in medicine food production. A very important section part which review patents concerning

Language: Английский

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The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 663 - 663

Published: March 7, 2023

Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They received considerable attention as potential therapeutic agents in biomedicine been widely used traditional complimentary medicine for generations. Such medical herbal formulations extremely complex mixtures many pharmacologically active provide outcome through network pharmacological effects complexity. Methods emerging to determine the components their targets decipher complexities how pharmacology provides such effects. The gut microbiome has important roles play generation bioactive flavonoid metabolites retaining or exceeding antioxidative anti-inflammatory properties intact and, some cases, new antitumor antineurodegenerative bioactivities. Certain food items identified with high prebiotic profiles suggesting neutraceutical supplementation may be beneficially employed preserve healthy population bacterial symbiont species minimize establishment harmful pathogenic organisms. Gut health is an consideration effecting overall wellbeing linked organ systems. Bioconversion generates can also transported by vagus nerve systemic circulation brain populations exert beneficial effect. This particularly number neurological disorders (autism, bipolar disorder, AD, PD) characterized on moods, resulting depression anxiety, impaired motor function, long-term cognitive decline. Native flavonoids alleviation inflammation tissues, however, concerns raised levels not achieved, thus allowing them display optimal Dietary manipulation vagal stimulation both yielded responses treatment autism spectrum disorders, depression, establishing route communication gut-brain axis established disease intervention. While native known penetrate blood–brain barrier, microbiome-generated (e.g., protocatechuic acid, urolithins, γ-valerolactones), which retain antioxidant potency addition promote mitochondrial cerebrovascular microcapillary should considered biotherapeutic agents. Studies warranted experimentally examine efficacy directly, they emerge novel options.

Language: Английский

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The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1439 - 1439

Published: March 23, 2024

Cancer is one of the leading causes death worldwide, making search for alternatives its control a critical issue. In this context, exploring from natural sources, such as certain vegetables containing variety secondary metabolites with beneficial effects on body and that play crucial role in fight against cancer, essential. Among compounds greatest efficacy controlling disease, those antioxidant activity, particularly phenolic com-pounds, stand out. A remarkable example group protocatechuic acid (PCA), which has been subject various revealing research activities different areas. These studies sustain anti-inflammatory, antimutagenic, antidiabetic, antiulcer, antiviral, antifibrogenic, antiallergic, neuroprotective, antibacterial, anticancer, antiosteoporotic, anti-aging, analgesic properties, addition to offering protection metabolic syndrome con-tributing preservation hepatic, renal, reproductive functionality. Therefore, paper aims review biological PCA, focusing anticancer potential in-volvement molecular pathways involved tumor development, sup-porting option promising alternative cancer treatment.

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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The role of natural antioxidants in cisplatin-induced hepatotoxicity

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 144, P. 112328 - 112328

Published: Oct. 14, 2021

Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identified, which started as excess generation of reactive oxygen species leads oxidative stress, inflammation, DNA damage and apoptosis liver. Various natural products, plant extracts oil rich flavonoids, terpenoids, polyphenols, phenolic acids were able minimize stress restoring level antioxidant enzymes acting an anti-inflammatory agent. Likewise, treatment with honey royal jelly was demonstrated decrease serum transaminases scavenge free radicals liver after administration. Medicinal properties these products promising potential complementary therapy counteract hepatotoxicity. This review concentrated on protective role several has proven laboratory findings combat

Language: Английский

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