Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(12), P. 1196 - 1196
Published: Nov. 27, 2020
Extensive
burns
result
in
a
local
wound
response
and
distant-organ
injury
(DOI)
caused
by
oxidative-stress
inflammation.
Melatonin
(MT)
shows
promise
alleviating
inflammation,
but
its
role
thermal
is
largely
unexplored.
The
present
systematic
review
meta-analysis
were
designed
to
assess
the
effects
of
MT
on
inflammatory
markers
against
severe
burn-induced
DOI.
Mean
difference
(MD)/standard
mean
(SMD)
with
95%
confidence
interval
(CI)
estimated
using
fixed-effect/random-effects
models.
Eighteen
experimental
studies
met
inclusion
criteria.
Compared
control
group,
significantly
decreased
levels
malondialdehyde
(SMD,
-1.03;
CI,
-1.30,
-0.76,
p
<
0.00001)
4-hydroxynonenal
(MD,
-1.06;
-1.57,
-0.56,
0.0001).
Additionally,
increased
glutathione
1.94;
1.27,
2.61,
superoxide-dismutase
0.76;
0.08,
1.45,
=
0.03).
Finally,
tumor
necrosis
factor-α
-1.34;
-1.92
-0.77;
C-reactive
protein
-12.67;
-16.72
-8.62;
0.00001).
Meta-analysis
indicates
that
burn
followed
immediate
(10
mg/kg)
intervention
significant
beneficial
after
24-h
DOI
regulating
response.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
23(1), P. 218 - 218
Published: Dec. 25, 2021
Obesity
and
its
complications
have
become
a
prominent
global
public
health
problem
that
severely
threatens
human
health.
Melatonin,
originally
known
as
an
effective
antioxidant,
is
endogenous
hormone
found
throughout
the
body
serves
various
physiological
functions.
In
recent
decades,
increasing
attention
has
been
paid
to
unique
function
in
regulating
energy
metabolism,
especially
glucose
lipid
metabolism.
Accumulating
evidence
established
relationship
between
melatonin
obesity;
nevertheless,
not
all
preclinical
clinical
indicates
anti-obesity
effect
of
melatonin,
which
makes
it
remain
conclude
fight
against
obesity.
this
review,
we
summarized
current
knowledge
obesity-related
symptoms,
with
emphasis
on
underlying
mechanisms.
The
role
profile,
adipose
tissue,
oxidative
stress,
inflammation,
well
interactions
circadian
rhythm,
gut
microbiota,
sleep
disorder,
α7nAChR,
opioidergic
system,
exosomes,
make
promising
agent
open
new
avenues
intervention
Frontiers in Integrative Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: March 29, 2022
Overweight
and
obesity
are
now
considered
a
worldwide
pandemic
growing
public
health
problem
with
severe
economic
social
consequences.
Adipose
tissue
is
an
organ
neuroimmune-endocrine
functions,
which
participates
in
homeostasis.
So,
adipocyte
hypertrophy
hyperplasia
induce
state
of
chronic
inflammation
that
causes
changes
the
brain
neuroinflammation.
Studies
obese
animal
models
patients
have
shown
relationship
between
diet
cognitive
decline,
especially
working
memory
learning
deficiencies.
Here
we
analyze
how
obesity-related
peripheral
can
affect
central
nervous
system
physiology,
generating
Given
blood-brain
barrier
interface
periphery
system,
its
altered
physiology
may
mediate
consequences
on
various
processes.
Finally,
several
interventions,
use
natural
compounds
exercise
to
prevent
adverse
effects
also
discussed.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: July 26, 2022
Dietary
regimens
are
crucial
in
the
management
of
non-alcoholic
fatty
liver
disease
(NAFLD).
The
effects
intermittent
fasting
(IF)
have
gained
attention
this
regard,
but
further
research
is
warranted.
Thus,
we
aimed
to
ascertain
overall
5:2
IF
diet
(5
days
a
week
normal
food
intake
and
2
consecutive
days)
patients
with
NAFLD
compared
control
group
(usual
diet).A
12-week
randomized
controlled
trial
was
performed
evaluate
on
anthropometric
indices,
body
composition,
serum
lipids,
glucose
metabolism,
inflammatory
markers
NAFLD.
(n
=
21)
decreased
weight
(86.65
±
12.57-82.94
11.60
kg),
mass
index
(30.42
2.27-29.13
1.95
kg/m2),
waist
circumference
(103.52
6.42-100.52
5.64
cm),
fat
(26.64
5.43-23.85
5.85
fibrosis
(6.97
1.94-5.58
1.07
kPa),
steatosis
scores/CAP
(313.09
25.45-289.95
22.36
dB/m),
alanine
aminotransferase
(41.42
20.98-28.38
15.21
U/L),
aspartate
(34.19
10.88-25.95
7.26
triglycerides
(171.23
39.88-128.04
34.88
mg/dl),
high-sensitivity
C-reactive
protein
(2.95
0.62
-2.40
0.64
mg/L),
cytokeratin-18
(1.32
0.06-1.19
0.05
ng/ml)
values
baseline
end
23)-p
≤
were
considered
as
significant.
However,
intervention
did
not
change
levels
high-density
lipoprotein
cholesterol,
total
low-density
blood
sugar,
insulin,
HOMA-IR,
antioxidant
capacity.Adhering
can
reduce
loss
related
parameters
(fat
indicators
obesity),
well
hepatic
steatosis,
enzymes,
triglycerides,
biomarkers
Annals of Medicine,
Journal Year:
2023,
Volume and Issue:
55(1), P. 1262 - 1286
Published: March 28, 2023
Disturbed
circadian
rhythms
have
been
a
risk
factor
for
type
2
diabetes
mellitus
(T2DM).
Melatonin
is
the
major
chronobiotic
hormone
regulating
both
rhythm
and
glucose
homeostasis.
The
rs10830963
(G
allele)
of
melatonin
receptor
1B
(MTNR1B)
gene
has
strongest
genetic
associations
with
T2DM
according
to
several
genome-wide
association
studies.
MTNR1B
G
allele
also
associated
disturbed
phenotypes
altered
secretion,
factors
that
can
elevate
diabetes.
Furthermore,
evolutionary
studies
implied
presence
selection
pressure
ethnic
diversity
in
MTNR1B,
which
was
consistent
"thrifty
gene"
hypothesis
T2DM.
delayed
secretion
onset
dim-light
prolonged
duration
peak
melatonin.
This
may
help
human
ancestors
adapt
famine
or
food
shortages
during
long
nights
early
mornings
avoid
nocturnal
hypoglycemia
but
confers
susceptibility
due
adequate
energy
intake
modern
society.
We
provide
new
insight
into
role
variants
via
from
perspective
hypothesis;
these
data
indicate
novel
target
prevention
treatment
susceptible
populations
thrifty
genotype.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 8, 2024
Despite
the
early
recognition
of
obesity
as
an
epidemic
with
global
implications,
research
on
its
pathogenesis
and
therapeutic
approach
is
still
rise.
The
literature
21st
century
records
excess
weight
found
in
up
to
1/3
children.
Both
determining
factors
systemic
effects
are
multiple
variable.
Regarding
involvement
potentiation
cardio-vascular,
pulmonary,
digestive,
metabolic,
neuro-psychic
or
even
dermatological
diseases,
information
already
broadly
outlined.
connection
between
underlying
disease
associated
comorbidities
seems
be
partially
attributable
oxidative
stress.
In
addition
these,
light
recent
COVID-19
pandemic,
role
played
by
stress
induction,
maintenance
chronic
inflammation
among
overweight
children
adolescents
becomes
a
topic
interest
again.
Thus,
this
review’s
purpose
update
general
data
obesity,
emphasis
physiopathological
mechanisms
that
underlie
it
involve
At
same
time,
we
briefly
present
latest
principles
pathology
diagnosis
management.
Among
will
mainly
emphasize
impact
endogenous
exogenous
antioxidants
evolutionary
course
pediatric
obesity.
order
achieve
our
objectives,
refer
most
studies
published
specialized
literature.
