Mechanisms of Melatonin in Obesity: A Review

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 23(1), P. 218 - 218

Published: Dec. 25, 2021

Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is endogenous hormone found throughout the body serves various physiological functions. In recent decades, increasing attention has been paid to unique function in regulating energy metabolism, especially glucose lipid metabolism. Accumulating evidence established relationship between melatonin obesity; nevertheless, not all preclinical clinical indicates anti-obesity effect of melatonin, which makes it remain conclude fight against obesity. this review, we summarized current knowledge obesity-related symptoms, with emphasis on underlying mechanisms. The role profile, adipose tissue, oxidative stress, inflammation, well interactions circadian rhythm, gut microbiota, sleep disorder, α7nAChR, opioidergic system, exosomes, make promising agent open new avenues intervention

Language: Английский

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Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 5080 - 5080

Published: Nov. 29, 2022

Obesity is a chronic and relapsing public health problem with an extensive list of associated comorbidities. The worldwide prevalence obesity has nearly tripled over the last five decades continues to pose serious threat wider society wellbeing future generations. pathogenesis complex but diet plays key role in onset progression disease. human changed drastically across globe, estimate that approximately 72% calories consumed today come from foods were not part our ancestral diets are compatible metabolism. Additionally, multiple nutrient-independent factors, e.g., cost, accessibility, behaviours, culture, education, work commitments, knowledge societal set-up, influence food choices eating patterns. Much research been focused on ‘what eat’ or ‘how much reduce burden, increasingly evidence indicates ‘when fundamental Aligning feeding patterns 24-h circadian clock regulates wide range physiological behavioural processes health-promoting effects anti-obesity being major part. This article explores current understanding interactions between body clocks, bioactive dietary components less appreciated meal timings energy homeostasis obesity.

Language: Английский

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Leptin Signaling Could Mediate Hippocampal Decumulation of Beta-Amyloid and Tau Induced by High-Intensity Interval Training in Rats with Type 2 Diabetes

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(7), P. 3465 - 3478

Published: June 28, 2023

Language: Английский

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Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 5, 2023

Abstract Background The objective of this systematic review and meta-analysis was to evaluate the effects non-surgical periodontal therapy (NSPT) on inflammatory-related cytokines/adipocytokines in periodontitis patients with or without obesity. Methods We followed preferred reporting items for reviews meta-analyses statement registered study (CRD42022375331) Prospective International Register Systematic Reviews. screened randomized-controlled trials controlled clinical from six databases up December 2022. Quality assessment performed RoB-2 ROBINS-I tools randomized non-randomized trials, respectively. Meta-analysis carried out using a random-effect model. Results included seventeen references analysis, sixteen meta-analysis. Baseline results pro-inflammatory biomarkers, including serum interleukin (IL)-6, gingival crevicular fluid (GCF), tumor necrosis factor (TNF)-a, C-reactive protein (CRP)/hs-CRP, GCF resistin, were higher obesity subjects than normal weight subjects. effect NSPT respect levels cytokines/adipocytokines, IL-6, TNF-a, CRP/hs-CRP, adiponectin, leptin retinol binding 4 (RBP4), then analyzed After three months NSPT, (MD = -0.54, CI -0.62 – -0.46), -2.70, -4.77 -0.63) along RBP4 -0.39, -0.68–0.10) decreased individuals also improved adiponectin after 2.37, 0.29 4.45) Conclusions Obese status altered baseline (serum resistin). Then can shift specific mediators anti-inflammatory biological fluids, both non-obesity individuals. reduce IL-6 together level 3 months, besides, there is no sufficient evidence prove that obese have statistically significant decrease other cytokines compared weight. increase months. Our findings imply potential ideal follow-up intervals sensitive biomarkers bioanalysis personalized decision-making due patients’ BMI value.

Language: Английский

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Cellular signalling of melatonin and its role in metabolic disorders

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 4, 2025

Language: Английский

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Association between Sleep disturbance and Metabolic dysfunctions in Adipose Tissue: Insights into Melatonin's Role

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151978 - 151978

Published: May 1, 2025

Language: Английский

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Hepatic Encephalopathy and Melatonin

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 837 - 837

Published: April 25, 2022

Hepatic encephalopathy (HE) is a severe metabolic syndrome linked with acute/chronic hepatic disorders. HE also pernicious neuropsychiatric complication associated cognitive decline, coma, and death. Limited therapies are available to treat HE, which formidable oversee in the clinic. Thus, determining novel therapeutic approach essential. The pathogenesis of has not been well established. According various scientific reports, neuropathological symptoms arise due excessive accumulation ammonia, transported brain via blood–brain barrier (BBB), triggering oxidative stress inflammation, disturbing neuronal-glial functions. treatment involves eliminating hyperammonemia by enhancing ammonia scavenging mechanism systemic blood circulation. Melatonin sole endogenous hormone HE. as neurohormone potent antioxidant that primarily synthesized released brain’s pineal gland. Several liver cirrhosis clinical studies have demonstrated impaired synthesis, secretion melatonin, circadian patterns. can cross BBB involved neuroprotective actions on brain. Hence, we aim elucidate how impairs functions, precise molecular melatonin reverses effects central nervous system.

Language: Английский

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Role of omentin-1 in susceptibility to anxiety and depression like behaviors

Molecular and Cellular Endocrinology, Journal Year: 2023, Volume and Issue: 574, P. 111990 - 111990

Published: June 15, 2023

Language: Английский

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Therapeutic Target Analysis and Molecular Mechanism of Melatonin - Treated Leptin Resistance Induced Obesity: A Systematic Study of Network Pharmacology

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: July 22, 2022

Background Obesity is a medical problem with an increased risk for other metabolic disorders like diabetes, heart problem, arthritis, etc. Leptin adipose tissue-derived hormone responsible food intake, energy expenditure, etc., and leptin resistance one of the significant causes obesity. Excess secretion by poor diet habits impaired hypothalamic signaling leads to LR. Melatonin sleep hormone; also possess antioxidant anti-inflammatory properties. The melatonin can attenuate complications obesity regulating its targets towards LR induced Aim aim this study includes molecular pathway network analysis using systems pharmacology approach identify potential therapeutic mechanism on resistance-induced Methods bioinformatic methods are used find in treatment It target gene identification public databases, Gene ontology, KEGG enrichment ‘ClusterProfiler’ R language, Cytoscape, Docking Autodock. Results We obtained common top 33 LR-induced from total 254 212 data screening method. They involved biological processes related obesity, including cellular response external stimulus, chemical stress, autophagy. From 180 enriched pathways, we took ten pathways further analysis, lipid atherosclerosis, endocrine, AGE-RAGE diabetic complications. 10 interacted genes created two functional modules. Using Cytoscape hub (TP53, AKT1, MAPK3, PTGS2, TNF, IL6, MAPK1, ERBB2, IL1B, MTOR) were identified MCC algorithm CytoHubba plugin. wide range classes, reduce risks major six classes. signal transduction, endocrine system, disease, environmental adaptation, drug antineoplastic, cardiovascular disease. Conclusion pharmacological action shows

Language: Английский

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The cross-talk between leptin and circadian rhythm signaling proteins in physiological processes: a systematic review

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(12), P. 10427 - 10443

Published: Oct. 24, 2023

Language: Английский

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