Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

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Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 1229 - 1253

Published: March 1, 2022

Abstract: Diabetes mellitus (DM) is among the chronic metabolic disorders that its incidence rate has shown an increase in developed and wealthy countries due to lifestyle obesity. The treatment of DM always been interest, significant effort made this field. Exosomes belong extracellular vesicles with nanosized features (30– 150 nm) are involved cell-to-cell communication preserving homeostasis. function exosomes different based on their cargo, they may contain lipids, proteins, nucleic acids. present review focuses application DM; both glucose lipid levels significantly affected by exosomes, these nanostructures enhance metabolism decrease deposition. Furthermore, promote affect level glycolytic enzymes transporters DM. Type I results from destruction β cells pancreas, can be employed ameliorate apoptosis endoplasmic reticulum (ER) stress cells. have dual functions mediating insulin resistance/sensitivity, M1 macrophage-derived inhibit secretion. miRNAs, transferring cells, regulate various molecular pathways such as AMPK, PI3K/Akt, β-catenin progression. Noteworthy, body fluids blood circulation, biomarkers for diagnosis diabetic patients. Future studies should focus engineering derived sources mesenchymal stem treat a novel strategy. Keywords: diabetes mellitus, resistance, exosome, uptake, Corrigendum paper published

Language: Английский

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Coffee or tea: Anti-inflammatory properties in the context of atherosclerotic cardiovascular disease prevention

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106596 - 106596

Published: Dec. 5, 2022

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflammation and its biomarkers, like C-reactive protein (CRP), among risk factors, such as hypertension, lipid disorders, diabetes, may be also responsible for residual (CVD) risk. Modern lipid-lowering treatment with statins, ezetimibe, PCSK9 inhibitors, or bempedoic acid does not fully protect against inflammation. The recommendations International Lipid Expert Panel (ILEP) indicate selected nutraceuticals anti-inflammatory properties. Diet have a significant impact on Especially interesting in context inflammation consumption coffee tea. These drinks many observational studies significantly reduced mortality. question whether effects these contribute to observed clinical effects. Thus, this narrative review, we primarily discuss properties consuming tea coffee. Based comprehensive analysis their meta-analyses, inconsistent results were obtained, which makes it impossible conclusively state how clinically potential black green are. A number confounding factors can inconsistency available results. Consumption appears increase adiponectin concentrations, decrease reactive oxygen species, low density lipoprotein (LDL) cholesterol concentrations (effect tea, etc.). Despite still uncertain effect coffee, recommend part healthy diet.

Language: Английский

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Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy

Life Sciences, Journal Year: 2022, Volume and Issue: 298, P. 120463 - 120463

Published: March 7, 2022

Language: Английский

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Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(11)

Published: Oct. 4, 2022

Language: Английский

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Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5171 - 5171

Published: March 8, 2023

Halophytes and xerophytes, plants with adequate tolerance to high salinity strong ability survive in drought ecosystem, have been recognized for their nutritional medicinal values owing comparatively higher productions of secondary metabolites, primarily the phenolics, flavonoids, as compared normal vegetation other climatic regions. Given consistent increases desertification around world, which are associated increasing salinity, temperature, water scarcity, survival halophytes due metabolic contents has prioritized these plant species, now become increasingly important environmental protection, land reclamation, food animal-feed security, primary utility traditional societies sources drugs. On herbs front, because fight against cancer is still ongoing, there an urgent need development more efficient, safe, novel chemotherapeutic agents, than those currently available. The current review describes secondary-metabolite-based chemical products promising candidates developing newer therapeutics. It further discusses prophylactic roles plants, constituents prevention management cancers, through exploration phytochemical pharmacological properties, a view on immunomodulation. various phenolics structurally diverse flavonoids major suppressing oxidative stress, immunomodulation, anti-cancer effects subject matter this aspects outlined details.

Language: Английский

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Modulatory effect of caffeic acid in alleviating diabetes and associated complications

World Journal of Diabetes, Journal Year: 2023, Volume and Issue: 14(2), P. 62 - 75

Published: Feb. 14, 2023

Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy, nephropathy, retinopathy, cardiovascular disorders, and foot ulcers. Excess production free radicals causing oxidative stress in tissues considered be primary cause onset progression DM associated complications. Natural polyphenols can used induce or inhibit expression antioxidant enzymes such as glutathione peroxidase, heme oxygenase-1, superoxide dismutase, catalase that are essential maintaining redox balance, ameliorate stress. Caffeic acid (CA) a polyphenolderived from hydroxycinnamic possesses numerous physiological properties includ-ing antioxidant, anti-inflammatory, anti-atherosclerotic, immune-stimulatory, cardioprotective, antiproliferative, hepatoprotective activities. CA acts regulatory compound affecting biochemical pathways multiple targets. These include various transcription factors nuclear factor-B, tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, factor erythroid 2-related 2. Therefore, this review summarizes pharmacological properties, molecular mechanisms, pharmacokinetic profile mitigating adverse effects The bioavailability, drug delivery, clinical trials have also been discussed.

Language: Английский

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The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116490 - 116490

Published: June 22, 2023

Language: Английский

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Research progress on the prevention and treatment of hyperuricemia by medicinal and edible plants and its bioactive components

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 12, 2023

Hyperuricemia is another common metabolic disease, which considered to be closely related the development of many chronic diseases, in addition "three highs." Currently, although drugs show positive therapeutic effects, they have been shown produce side effects that can damage body. There growing evidence medicinal and edible plants their bioactive components a significant effect on hyperuricemia. In this paper, we review with uric acid-lowering summarize mechanisms different components. Specifically, are divided into five categories: flavonoids, phenolic acids, alkaloids, polysaccharides, saponins. These active substances exhibit by inhibiting acid production, promoting excretion, improving inflammation. Overall, examines potential role as means combating hyperuricemia, hope providing some reference value for treatment

Language: Английский

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Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

Food & Function, Journal Year: 2023, Volume and Issue: 14(16), P. 7705 - 7717

Published: Jan. 1, 2023

CA supplementation could enhance intestinal integrity and barrier function by modifying microbiota its metabolites, which lead to a reduction in inflammatory responses oxidative stress LPS-challenged piglets.

Language: Английский

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