Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 15, 2023
The
prevalence
of
type
2
diabetes
(T2D)
is
increasing
worldwide,
with
many
patients
developing
long-term
complications
that
affect
their
cardiovascular,
urinary,
alimentary,
and
other
systems.
A
growing
body
literature
has
reported
the
crucial
role
gut
microbiota
in
metabolic
diseases,
one
which,
Akkermansia
muciniphila,
considered
“next-generation
probiotic”
for
alleviating
disorders
inflammatory
response.
Although
extensive
research
been
conducted
on
A.
muciniphila
,
none
summarized
its
regulation
T2D.
Hence,
this
review
provides
an
overview
effects
multifaceted
mechanisms
T2D
related
including
improving
metabolism,
inflammation,
enhancing
intestinal
barrier
function,
maintaining
homeostasis.
Furthermore,
summarizes
dietary
strategies
abundance
effective
gastrointestinal
delivery.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 30, 2023
"Probiotic
therapy"
to
regulate
gut
microbiota
and
intervene
in
intestinal
diseases
such
as
inflammatory
bowel
disease
(IBD)
has
become
a
research
hotspot.
Bacteroides
acidifaciens,
new
generation
of
probiotics,
shown
beneficial
effects
on
various
diseases.In
this
study,
we
utilized
mouse
colitis
model
induced
by
dextran
sodium
sulfate
(DSS)
investigate
how
B.
acidifaciens
positively
affects
IBD.
We
evaluated
the
ofB.
fecal
transplantation,
bacterial
extracellular
vesicles
(EVs)
DSS-induced
mice.
monitored
phenotype
colitis,
detected
serum
factors
using
ELISA,
mucosal
barrier
function
Western
blotting
tissue
staining,
16S
rRNA
sequencing,
analyzed
differences
EVs
protein
composition
derived
from
proteomics
explore
positive
impact
colitis.We
confirmed
that
protective
effect
including
alleviating
phenotype,
reducing
response,
improving
function,
accompanied
an
increase
relative
abundance
Ruminococcus
callidus
but
decrease
fragilis.
Further
transplantation
or
filtrate
eosinophil-regulated
metabolites
colitis.
Finally,
validated
contain
rich
functional
proteins
can
contribute
relief
colitis.Therefore,
its
alleviate
damage
colon
tissue,
promoting
repair,
restoring
diversity,
balance
The
results
study
provide
theoretical
basis
for
preclinical
application
probiotics.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(45)
Published: June 26, 2023
Abstract
Possessing
the
largest
surface
area
of
mucosa
in
body,
gastrointestinal
(GI)
tract
can
easily
sufferfrom
inflammatory
damage
under
various
adverse
external
exposures,
resulting
occurrence
bowel
disease
(IBD).
Excessive
reactive
oxygen
species
(ROS)
usually
lead
to
local
mucosal
injury,
accelerate
formation
niduses,
andamplify
and
immune
response.
Antioxidant
therapy,
therefore,
is
considered
as
a
potential
strategy
against
IBDs.
Herein,
series
novel
dihydromyricetin‐based
nanoassemblies
with
excellent
antioxidant
activities
high
dispersion
GI
oral
preparations
are
developed
for
targeted
IBD
treatment.
By
changing
raw
materials,
current
be
well
extended
preparation
other
insoluble
natural
flavonoid
compound‐based
nanoassemblies.
The
well‐designed
dihydromyricetin‐PEG
1000‐based
(DMY‐1000
NAs)
stability
great
ROS
scavenging
capacity
harsh
environment
hold
an
admirable
capability
toward
intestinal
inflamed
lesions.
Therefore,
these
biocompatible
DMY‐1000
NAs
show
promising
therapeutic
effects
typical
IBDs
including
ulcerative
colitis
Crohn's
murine
models.
This
study
not
only
provides
new
method
constructing
therapy
platforms
but
also
illustrates
their
prominent
promise
Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Sept. 6, 2023
According
to
the
Chinese
Pharmacopoeia,
fruit
of
Schisandra
chinensis
(Turcz.)
Baill.
(SC)
is
an
important
traditional
medicine
that
can
be
used
treat
diarrhea.
Despite
increasing
research
on
anti-inflammatory
and
anti-oxidant
aspects
SC,
studies
anti-ulcerative
colitis
Schisandrin
(SCH),
main
constituent
are
relatively
few.The
mice
in
study
were
randomly
distributed
into
6
groups:
control,
model,
5-ASA,
SCH
(20,
40,
80
mg/kg/d).
The
model
group
administered
3%
(w/v)
dextran
sulfate
sodium
(DSS)
through
drinking
water
for
7
days,
various
parameters
disease
activity
index
(DAI)
such
as
body
weight
loss,
stool
consistency,
gross
blood
measured.
ELISA
was
detect
inflammatory
factors,
bioinformatics
combined
with
transcriptome
analysis
done
screen
verify
relevant
targets.
16S
rDNA
high-throughput
sequencing
analyze
composition
gut
microbiota(GM),
while
mass
spectrometry
changes
content
bile
acids
(BAs)
intestine.Mice
treated
experienced
significant
gain,
effectively
alleviating
severity
colitis,
decreasing
levels
factors
TNF-α,
IL-1β,
IL-18,
IL-6,
other
related
proteins
(NLRP3,
Caspase-1,
SGK1)
UC
mice.
Furthermore,
GM
BAs
revealed
increased
relative
abundance
Lactobacilli
spp,
reduced
Bacteroides,
promoted
conversion
primary
secondary
BAs.
These
effects
contributed
a
improvement
DSS-induced
imbalance
maintenance
intestinal
homeostasis.It
seems
there
close
relationship
between
mechanism
regulation
SGK1/NLRP3
pathway
restoration
balance.
Therefore,
it
concluded
could
potential
drug
treatment
UC.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 20, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
condition
affecting
the
gastrointestinal
tract.
Disturbed
gut
microbiota
abnormal
bile
acid
(BA)
metabolism
are
notable
in
IBD,
suggesting
bidirectional
relationship.
Specifically,
diversity
of
influences
BA
composition,
whereas
altered
profiles
can
disrupt
microbiota.
IBD
patients
often
exhibit
increased
primary
reduced
secondary
concentrations
due
to
diminished
bacteria
population
essential
for
metabolism.
This
imbalance
activates
receptors,
undermining
intestinal
integrity
immune
function.
Consequently,
targeting
microbiota-BA
axis
may
rectify
these
disturbances,
offering
symptomatic
relief
IBD.
Here,
interplay
between
acids
(BAs)
reviewed,
with
particular
focus
on
role
mediating
biotransformation,
contributions
pathology
unveil
potential
novel
therapeutic
avenues
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 13, 2025
The
conversion
of
primary
bile
acids
to
secondary
by
the
gut
microbiota
has
been
implicated
in
colonic
inflammation.
This
study
investigated
role
related
acid
metabolism
inflammation
both
patients
with
inflammatory
bowel
disease
(IBD)
and
a
murine
model
dextran
sulfate
sodium
(DSS)-induced
colitis.
Bile
fecal
samples
from
IBD
DSS-induced
colitis
mice,
without
antibiotic
treatment,
were
analyzed
using
ultraperformance
liquid
chromatography-mass
spectrometry
(UPLC-MS).
composition
DSS-colitis
mice
was
characterized
via
Illumina
MiSeq
sequencing
bacterial
16S
rRNA
gene
V3-V4
region.
Metagenomic
profiling
further
identified
metabolism-related
signatures
stool
mice.
Histological
analysis,
quantitative
PCR
(qPCR)
Western
Blotting
conducted
on
assess
inflammation,
mucosal
barrier
integrity,
associated
signaling
pathways.
multivariate
analysis
Soft
Independent
Modelling
Class
Analogy
(SIMCA,
Umetrics,
Sweden).
relation
between
relative
abundance
specific
phyla/genera
concentration
through
Spearman's
correlation
analyses.
Finally,
lithocholic
(LCA),
key
acid,
administered
gavage
evaluate
its
effect
integrity.
In
IBD,
altered.
Moreover,
changes
modulate
intestine.
As
continues
shift,
profile
undergoes
additional
alterations.
aforementioned
alterations
also
observed
revealed
dysbiosis
modifications
acids,
notably
LCA
Through
as
that
significantly
affects
integrity
barrier.
Subsequent
experiments
confirmed
supplementation
effectively
mitigated
inhibitory
effects
progression
primarily
activation
sphingosine-1-phosphate
receptor
2
(S1PR2)/NF-κB
p65
pathway.
Analysis
microbiome
metagenomic
data
microbiota,
an
increased
unclassified
genus
within
family
Prevotellaceae
Furthermore,
positive
biosynthesis
pathways,
well
level.
These
findings
suggest
positively
correlated
bacteria,
Prevotellaceae,
are
closely
intestinal
Targeting
may
involve
inhibiting
members
potential
therapeutic
strategies.
Foods,
Journal Year:
2025,
Volume and Issue:
14(4), P. 619 - 619
Published: Feb. 13, 2025
The
consumption
of
wampee
has
traditionally
been
utilized
to
alleviate
gastrointestinal
inflammation
and
associated
disorders;
however,
its
exact
mechanism
remained
unknown.
aim
this
study
was
elucidate
the
therapeutic
efficacy
underlying
polyphenol
extract
(WPE)
in
dextran
sulfate
sodium
(DSS)-induced
ulcerative
colitis
(UC).
findings
revealed
that
WPE
alleviated
diverse
symptoms
UC,
regulated
various
inflammatory
cytokines,
effectively
protected
colon
tissue
structure
barrier
integrity,
thereby
inhibiting
LPS
translocation.
Moreover,
restored
richness
diversity
gut
microbiota
optimized
at
phylum
genus
levels,
causing
a
notable
improvement
short-
chain
fatty
acid
(SCFA)
metabolism,
particularly
acetic
acid,
propionic
butyric
acid.
Consequently,
demonstrated
suppress
LPS-induced
TLR4-p38
MAPK/NF-κB
signaling
pathway
by
modulating
SCFA
metabolism.
These
provided
theoretical
basis
for
use
as
potential
functional
natural
food
UC.
