Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 173, P. 108292 - 108292
Published: March 13, 2024
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 26, 2025
Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.
Language: Английский
Citations
2
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 2, 2024
As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.
Language: Английский
Citations
11
Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155738 - 155738
Published: June 1, 2024
Respiratory diseases pose a grave threat to human life. Therefore, understanding their pathogenesis and therapeutic strategy is important. Ferroptosis novel type of iron-dependent programmed cell death, distinct from apoptosis, necroptosis, autophagy, characterised by iron, reactive oxygen species, lipid peroxide accumulation, as well glutathione (GSH) depletion GSH peroxidase 4 (GPX4) inactivation. A close association between ferroptosis the onset progression respiratory diseases, including chronic obstructive pulmonary disease, acute lung injury, bronchial asthma, fibrosis, cancer, has been reported. Recent studies have shown that traditional Chinese medicine (TCM) compounds exhibit unique advantages in treatment owing natural properties potential efficacy. These can effectively regulate modulating several key signalling pathways such system Xc
Language: Английский
Citations
11
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155384 - 155384
Published: Jan. 28, 2024
Language: Английский
Citations
8
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 218, P. 190 - 204
Published: April 2, 2024
Language: Английский
Citations
7
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(9), P. 4476 - 4489
Published: Aug. 6, 2024
In this study, we prepared bionic selenium-baicalein nanoparticles (ACM-SSe-BE) for the targeted treatment of nonsmall cell lung cancer. Due to coating A549 membrane, system has homologous targeting capabilities, allowing preparation target tumor cells. The borate ester bond between selenium (SSe) and baicalein (BE) is pH-sensitive can break under acidic conditions in microenvironment achieve release BE at site. Moreover, SSe further enhances antitumor effect by increasing production ROS Transmission electron microscopy (TEM) images dynamic light scattering (DLS) showed that ACM-SSe-BE had a particle size approximately 155 ± 2 nm. FTIR verified successful coupling BE. vitro experiments indicated cumulative pH 5.5 after 24 h was 69.39 1.07%, which less than 20% 7.4, confirming ACM-SSe-BE. Cell uptake vivo imaging good ability. results MTT, flow cytometry, Western blot, immunofluorescence staining demonstrated promoted apoptosis inhibited proliferation. were consistent with those experiments. These clearly suggested will be promising nanosystem
Language: Английский
Citations
6
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 16, 2024
Ferroptosis, distinct from apoptosis, is a novel cellular death pathway characterized by the build-up of lipid peroxidation and reactive oxygen species (ROS) derived lipids within cells. Recent studies demonstrated efficacy ferroptosis inducers in targeting malignant cells, thereby establishing promising avenue for combating cancer. Traditional Chinese medicine (TCM) has long history use widely used cancer treatment. TCM takes holistic approach, viewing patient as system utilizing herbal formulas to address complex diseases such have elucidated molecular mechanisms underlying induction during These identified numerous plant metabolites derivatives that target multiple pathways targets. can induce tumor cells through various regulatory mechanisms, amino acid, iron, metabolism pathways, which may provide therapeutic strategies apoptosis-resistant also influence anticancer immunotherapy via ferroptosis. This review comprehensively elucidates ferroptosis, highlights pivotal genes involved orchestrating this process, evaluates advancements made research pertaining provides theoretical insights into tumors using botanical drugs.
Language: Английский
Citations
4
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: March 7, 2024
Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role ferroptosis, unique cell mechanism, in lung cancer. This review aims to summarize current research progress on relationship between ferroptosis It also provides comprehensive analysis regulatory processes various stages, including epigenetics, transcription, post-transcription, translation, post-translation. Additionally, explores dual nature progression, which presents interesting therapeutic possibilities. On one hand, can promote escape immune surveillance reduce efficacy treatment early stages tumors. other it counter drug resistance, enhance radiosensitivity, immunotherapy. The article discusses combination strategies based mechanism ferroptosis. Overall, this offers holistic perspective onset, contribute future clinical interventions field.
Language: Английский
Citations
4
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112794 - 112794
Published: Aug. 12, 2024
Language: Английский
Citations
4
Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: Jan. 11, 2025
Labdane diterpenoid lactone andrographolide has gained attention in medicinal research due to its potential anticancer properties terms of suppression the growth, propagation, and relocation various types cancerous cells. The current review provides deep insight into pharmacological analysis secondary metabolite andrographolide. We have attempted keep an overview on interaction promising drugs like ligand molecule with biological targets. observation indicates that significantly down-regulates growth cancer cells through mechanisms
Language: Английский
Citations
0