Amino acid metabolism disorder and oxidative stress took part in EGCG alleviating Mn-caused ferroptosis via miR-9-5p/got1 axis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137656 - 137656

Published: Feb. 21, 2025

Language: Английский

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Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

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Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114262 - 114262

Published: Feb. 11, 2025

Language: Английский

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Ferroptosis, a Regulated Form of Cell Death, as a Target for the Development of Novel Drugs Preventing Ischemia/Reperfusion of Cardiac Injury, Cardiomyopathy and Stress-Induced Cardiac Injury

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 897 - 897

Published: Jan. 11, 2024

The hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is about 6% and has not decreased recent years. leading cause of death these ischemia/reperfusion (I/R) cardiac injury. It quite obvious that there an urgent need to create new drugs for the treatment STEMI based on knowledge pathogenesis I/R injury, particular, molecular mechanism ferroptosis. In this study, it was demonstrated ferroptosis involved development antitumor drug-induced cardiomyopathy, diabetic septic inflammation. There indirect evidence participates stress-induced activation AMPK, PKC, ERK1/2, PI3K, Akt prevents inhibition HO-1 alleviates roles GSK-3β NOS regulation require further study. stimulation Nrf2, STAT3 TLR4 NF-κB promotes cardiomyocytes. MiR-450b-5p miR-210-3p can increase tolerance cardiomyocytes hypoxia/reoxygenation through Circ_0091761 RNA, miR-214-3p, miR-199a-5p, miR-208a/b, miR-375-3p, miR-26b-5p miR-15a-5p aggravate

Language: Английский

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Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117081 - 117081

Published: July 5, 2024

The discovery of an inhibitor for acyl-CoA synthetase long-chain family member 4 (ACSL4), a protein involved in the process cell injury through ferroptosis, has potential to ameliorate damage. In this study, we aimed investigate berberine (BBR) as ACSL4 order suppress endothelial ferroptosis and provide protection against atherosclerosis. An atherosclerosis model was created ApoE

Language: Английский

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TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155597 - 155597

Published: April 21, 2024

Language: Английский

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Nicotinamide riboside attenuates myocardial ischemia-reperfusion injury via regulating SIRT3/SOD2 signaling pathway

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116689 - 116689

Published: May 3, 2024

Ischemic heart disease invariably leads to devastating damage human health. Nicotinamide ribose (NR), as one of the precursors NAD+ synthesis, has been discovered exert a protective role in various neurological and cardiovascular disorders. Our findings demonstrated that pretreatment with 200 mg/kg NR for 3 h significantly reduced myocardial infarct area, decreased levels CK-MB LDH serum, improved cardiac function rats during ischemia-reperfusion (I/R) injury. Meanwhile, 0.5 mM also effectively increased viability release H9c2 cells OGD/R. We had provided evidence could decrease mitochondrial reactive oxygen species (mtROS) production MDA content, enhance SOD activity, thereby mitigating inhibiting apoptosis I/R Further investigations revealed content upregulated SIRT3 protein expression myocardium. Through using small interfering RNA deacetylase activity inhibitor 3-TYP, we confirmed cardioprotective effect on cardiomyocytes was largely dependent inhibition oxidative stress via SIRT3-SOD2 axis. Overall, our study suggested exogenous supplementation mitigated inhibited injury by reducing SIRT3-SOD2-mtROS pathway.

Language: Английский

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Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103321 - 103321

Published: Aug. 19, 2024

Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.

Language: Английский

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Ferroptosis in senescence and age-related diseases: pathogenic mechanisms and potential intervention targets

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 17, 2025

Language: Английский

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ROS-mediated ferroptosis and pyroptosis in cardiomyocytes: An update

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123565 - 123565

Published: March 1, 2025

Language: Английский

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