Journal of Neuroinflammation,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: July 29, 2024
Abstract
Traumatic
brain
injury
(TBI)
remains
a
leading
cause
of
death
and
disability
that
places
great
physical,
social,
financial
burden
on
individuals
the
health
system.
In
this
review,
we
summarize
new
research
into
metabolic
changes
described
in
clinical
TBI
trials,
some
which
have
already
shown
promise
for
informing
classification
staging.
We
focus
our
discussion
derangements
glucose
metabolism,
cell
respiration/mitochondrial
function
to
ketone
lipid
metabolism/oxidation
emphasize
potentially
novel
biomarkers
outcome
prediction
intervention
offer
insights
possible
underlying
mechanisms
from
preclinical
pathology.
Finally,
discuss
nutrition
supplementation
studies
aim
harness
gut/microbiome-brain
connection
manipulate
systemic/cellular
metabolism
improve
post-TBI
recovery.
Taken
together,
narrative
review
summarizes
published
TBI-associated
highlighting
potential
metabolite
use,
cellular
processes
linking
these
markers
pathology
as
well
limitations
future
considerations
“omics”
work.
Human Brain Mapping,
Journal Year:
2022,
Volume and Issue:
44(3), P. 1251 - 1277
Published: Oct. 21, 2022
This
review
provides
a
qualitative
and
quantitative
analysis
of
cerebral
glucose
metabolism
in
ageing.
We
undertook
systematic
literature
followed
by
pooled
effect
size
activation
likelihood
estimates
(ALE)
meta-analyses.
Studies
were
retrieved
from
PubMed
following
the
PRISMA
guidelines.
After
reviewing
635
records,
21
studies
with
22
independent
samples
(n
=
911
participants)
included
analyses.
Eight
eleven
separate
713
ALE
Pooled
sizes
showed
significantly
lower
metabolic
rates
for
older
versus
younger
adults
whole
brain,
as
well
frontal,
temporal,
parietal,
occipital
lobes.
Among
sub-cortical
structures,
caudate
rate
among
adults.
In
sub-group
analyses
controlling
changes
brain
volume
or
partial
effects,
frontal
lobe
remained
significant,
whereas
confidence
intervals
crossed
zero
other
lobes
structures.
The
identified
nine
clusters
adults,
ranging
200
to
2640
mm3
.
two
largest
left
right
inferior
superior
temporal
gyri
insula.
Clusters
also
found
junction,
anterior
cingulate
caudate.
Taken
together,
results
are
consistent
research
showing
less
efficient
ageing
brain.
findings
discussed
context
theories
cognitive
compared
those
neurodegenerative
disease.
Neurobiology of Disease,
Journal Year:
2023,
Volume and Issue:
182, P. 106145 - 106145
Published: May 5, 2023
Disrupted
brain
metabolism
is
a
critical
component
of
several
neurodegenerative
diseases.
Energy
both
neurons
and
astrocytes
closely
connected
to
neurotransmitter
recycling
via
the
glutamate/GABA-glutamine
cycle.
Neurons
hereby
work
in
close
metabolic
collaboration
which
essential
sustain
neurotransmission.
Elucidating
mechanistic
involvement
altered
disease
progression
has
been
aided
by
advance
techniques
monitor
cellular
metabolism,
particular
mapping
substrates
containing
stable
isotopes,
technique
known
as
isotope
tracing.
Here
we
review
key
aspects
tracing
including
advantages,
drawbacks
applications
different
cerebral
preparations.
In
addition,
narrate
how
facilitated
discovery
central
features
neurodegeneration
with
focus
on
cooperation
between
astrocytes.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(7), P. 1473 - 1479
Published: Nov. 8, 2023
Abstract
Although
antipsychotics
that
act
via
monoaminergic
neurotransmitter
modulation
have
considerable
therapeutic
effect,
they
cannot
completely
relieve
clinical
symptoms
in
patients
suffering
from
psychiatric
disorders.
This
may
be
attributed
to
the
limited
range
of
neurotransmitters
are
regulated
by
psychotropic
drugs.
Recent
findings
indicate
need
for
investigation
medications
target
less-studied
neurotransmitters.
Among
these
candidate
neurotransmitters,
lactate
is
developing
being
a
waste
metabolite
glial-neuronal
signaling
molecule
recent
years.
Previous
studies
suggested
cerebral
levels
change
considerably
numerous
illnesses;
animal
experiments
also
shown
supply
exogenous
exerts
an
antidepressant
effect.
In
this
review,
we
described
how
targeting
newer
offer
promise
diseases;
summarized
advances
use
(and
its
corresponding
pathways)
as
molecule.
addition,
alterations
brain
depression,
anxiety,
bipolar
disorder,
and
schizophrenia
indicated
challenges
overcome
before
can
used
psychopharmacology.
Journal of Neuroinflammation,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: July 29, 2024
Abstract
Traumatic
brain
injury
(TBI)
remains
a
leading
cause
of
death
and
disability
that
places
great
physical,
social,
financial
burden
on
individuals
the
health
system.
In
this
review,
we
summarize
new
research
into
metabolic
changes
described
in
clinical
TBI
trials,
some
which
have
already
shown
promise
for
informing
classification
staging.
We
focus
our
discussion
derangements
glucose
metabolism,
cell
respiration/mitochondrial
function
to
ketone
lipid
metabolism/oxidation
emphasize
potentially
novel
biomarkers
outcome
prediction
intervention
offer
insights
possible
underlying
mechanisms
from
preclinical
pathology.
Finally,
discuss
nutrition
supplementation
studies
aim
harness
gut/microbiome-brain
connection
manipulate
systemic/cellular
metabolism
improve
post-TBI
recovery.
Taken
together,
narrative
review
summarizes
published
TBI-associated
highlighting
potential
metabolite
use,
cellular
processes
linking
these
markers
pathology
as
well
limitations
future
considerations
“omics”
work.
