The connectivity of the human frontal pole cortex, and a theory of its involvement in exploit versus explore DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 34(1)

Published: Nov. 21, 2023

Abstract The frontal pole is implicated in humans whether to exploit resources versus explore alternatives. Effective connectivity, functional and tractography were measured between six human regions for comparison 13 dorsolateral dorsal prefrontal cortex regions, the 360 cortical Human Connectome Project Multi-modal-parcellation atlas 171 HCP participants. have effective connectivity with Dorsolateral Prefrontal Cortex Dorsal Cortex, both working memory; orbitofrontal anterior cingulate reward/non-reward system. There also temporal lobe, inferior parietal, posterior regions. Given this new evidence, evidence from activations damage, it proposed that contains autoassociation attractor networks are normally stable a short-term memory state, maintain stability other during exploitation of goals strategies. However, if an input or expected reward, non-reward, punishment received, destabilizes thereby enable exploration competing alternative reward systems may be key explore.

Language: Английский

Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala DOI Creative Commons
Edmund T. Rolls

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 228(5), P. 1201 - 1257

Published: May 13, 2023

The orbitofrontal cortex and amygdala are involved in emotion motivation, but the relationship between these functions performed by brain structures is not clear. To address this, a unified theory of motivation described which motivational states instrumental goal-directed actions to obtain rewards or avoid punishers, emotional that elicited when reward punisher received. This greatly simplifies our understanding for same set genes associated systems can define primary unlearned punishers such as sweet taste pain. Recent evidence on connectivity human indicates value experienced with outputs cortical regions including those language, key region depression changes motivation. has weak effective back humans, implicated brainstem-mediated responses stimuli freezing autonomic activity, rather than declarative emotion. anterior cingulate learning rewards, ventromedial prefrontal providing goals navigation reward-related effects memory consolidation mediated partly via cholinergic system.

Language: Английский

Citations

126
The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome: emotion, memory, and action DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(2), P. 330 - 356

Published: Feb. 4, 2022

The human orbitofrontal cortex, ventromedial prefrontal cortex (vmPFC), and anterior cingulate are involved in reward processing thereby emotion but also implicated episodic memory. To understand these regions better, the effective connectivity between 360 cortical 24 subcortical was measured 172 humans from Human Connectome Project complemented with functional diffusion tractography. has gustatory, olfactory, temporal visual, auditory, pole areas. to pregenual posterior hippocampal system provides for rewards be used memory navigation goals. have supracallosal which projects midcingulate other premotor areas action-outcome learning including limb withdrawal or flight fight aversive nonreward stimuli. lateral outputs language systems inferior frontal gyrus. medial connects nucleus basalis of Meynert septum, damage may contribute impairments by disrupting cholinergic influences on neocortex hippocampus.

Language: Английский

Citations

89
Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment DOI
Bei Zhang, Edmund T. Rolls, Xiang Wang

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(4), P. 914 - 928

Published: Jan. 12, 2024

Language: Английский

Citations

47
Hippocampal storage and recall of neocortical “What”–“Where” representations DOI Creative Commons
Edmund T. Rolls, Chenfei Zhang, Jianfeng Feng

et al.

Hippocampus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract A key question for understanding the function of hippocampus in memory is how information recalled from to neocortex. This was investigated a neuronal network model hippocampal system which “What” and “Where” firing rate vectors were applied separate neocortical modules, then activated entorhinal cortex dentate gyrus, CA3, CA1, cortex, backprojections showed that whole could be trained recall neocortex as retrieval cue neocortex, principle up towards theoretical capacity determined largely by number synapses onto any one neuron divided sparseness representation. The synaptic weights imported into an integrate‐and‐fire simulation same architecture, time presenting module approximately 100 ms. sufficiently fast backprojection still active neurons during storage episodic memory, this needed operate correctly These simulations also long loop neocortex–hippocampus–neocortex operates continuously may contribute complete neocortex; but positive feedback makes dynamical inherently liable pathological increase activity. Important factors contributed stability included increased inhibition CA3 CA1 keep rates low; temporal adaptation synapses, are proposed make important contribution stabilizing runaway excitation cortical circuits brain.

Language: Английский

Citations

32
The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation DOI
Edmund T. Rolls, Sylvia Wirth, Gustavo Deco

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(2), P. 629 - 655

Published: Sept. 30, 2022

The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory navigation. functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of Posterior Cingulate Division (PCD) regions Human Connectome Project-MMP1 atlas 171 HCP participants, complemented with diffusion tractography. First, postero-ventral parts PCD (31pd, 31pv, 7m, d23ab, v23ab) have temporal pole, inferior visual cortex, superior sulcus implicated auditory semantic processing, reward-related vmPFC pregenual anterior cingulate hippocampal system. This implicates it episodic memory, providing routes for "what," reward schema-related information to access hippocampus. Second, antero-dorsal (especially 31a 23d, PCV, also RSC) early cortical areas including those that represent spatial scenes, "where" component dorsal-transitional-visual (DVT) ProStriate where retrosplenial scene area is located from parahippocampal area, a ventromedial route reach These connectivities provide important reward, scene-related midcingulate provides dorsal supracallosal part premotor regions.

Language: Английский

Citations

60
Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans DOI Creative Commons
Edmund T. Rolls

Hippocampus, Journal Year: 2022, Volume and Issue: 33(5), P. 533 - 572

Published: Sept. 7, 2022

Abstract Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the location being looked at. The representation is allocentric, that responses are locations “out there” world, relatively invariant with respect retinal position, eye head direction, place where individual located. underlying connectivity humans from ventromedial visual cortical regions scene area, leading theory cells formed by combinations of overlapping feature inputs self‐organized based on their closeness space. Thus, although represent “where” for episodic memory navigation, they ventral stream what area. A second driver parietal inputs, which it proposed provide idiothetic update cells, used recall navigation when details obscured. Inferior temporal object “what” orbitofrontal cortex reward connect human hippocampal system, macaques can be associated hippocampus cell representations implement memory. also a basis series viewed landmarks, providing goals then implemented involved visuomotor actions presence foveate vision highly developed lobe processing including key understanding primate hippocampus, roles this system navigation.

Language: Английский

Citations

57
The human posterior parietal cortex: effective connectome, and its relation to function DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(6), P. 3142 - 3170

Published: July 14, 2022

Abstract The effective connectivity between 21 regions in the human posterior parietal cortex, and 360 cortical was measured 171 Human Connectome Project (HCP) participants using HCP atlas, complemented with functional diffusion tractography. Intraparietal areas LIP, VIP, MIP, AIP have from early visual regions, to visuomotor such as frontal eye fields, consistent functions saccades tracking. Five superior area 7 receive similar intraparietal areas, but also somatosensory inputs connect premotor including 6, performing actions reach for, grasp, manipulate objects. In anterior inferior PFop, PFt, PFcm are mainly somatosensory, PF addition receives visuo-motor object information, is implicated multimodal shape body image representations. PFm PGs combine visuo-motor, object, reward input hippocampal system. PGi provides a route motion-related temporal sulcus involved social interactions. PGp has coordinate transforms may be idiothetic update of scene

Language: Английский

Citations

56
Multiple cortical visual streams in humans DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(7), P. 3319 - 3349

Published: July 14, 2022

The effective connectivity between 55 visual cortical regions and 360 was measured in 171 HCP participants using the HCP-MMP atlas, complemented with functional diffusion tractography. A Ventrolateral Visual "What" Stream for object face recognition projects hierarchically to inferior temporal cortex, which orbitofrontal cortex reward value emotion, hippocampal memory system. Ventromedial "Where" scene representations connects parahippocampal gyrus hippocampus. An Inferior STS (superior sulcus) Semantic receives from Stream, parietal PGi, ventromedial-prefrontal system language systems. Dorsal via V2 V3A MT+ Complex (including MT MST), connect intraparietal LIP, VIP MIP) involved motion actions space. It performs coordinate transforms idiothetic update of representations. Superior inputs STV, auditory A5, is activated by expression, vocalization, important social behaviour,

Language: Английский

Citations

43
Prefrontal and somatosensory-motor cortex effective connectivity in humans DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(8), P. 4939 - 4963

Published: Oct. 13, 2022

Abstract Effective connectivity, functional and tractography were measured between 57 cortical frontal somatosensory regions the 360 in Human Connectome Project (HCP) multimodal parcellation atlas for 171 HCP participants. A ventral stream connects from 3b 3a via 1 2 then opercular to insula, which inferior parietal PF regions. This is implicated “what”-related processing of objects body combining with visual inputs PF. dorsal “action” area 5 7. Inferior prefrontal have connectivity temporal cortex orbitofrontal cortex, are working memory “what” streams, provide language systems, including 44, 45, 47l, TPOJ1, superior area. The dorsolateral that include 46 7 actions planning. regions, 8Ad 8Av, PGs PGi, auditory top-down attention.

Language: Английский

Citations

39
Episodic Memory formation: A review of complex Hippocampus input pathways DOI

Krubeal Danieli,

Alice Guyon, Ingrid Bethus

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 126, P. 110757 - 110757

Published: April 21, 2023

Language: Английский

Citations

32