Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence DOI Creative Commons
Qing Ma, Hui Wang, Edmund T. Rolls

et al.

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 3, 2022

Abstract Background Gestational age (GA) is associated with later cognition and behavior. However, it unclear how specific cognitive domains brain structural development varies the stepwise change of gestational duration. Methods This large-scale longitudinal cohort study analyzed 11,878 early adolescents’ volume maps at 9–10 years (baseline) 5685 11–12 (a 2-year follow-up) from Adolescent Brain Cognitive Development (ABCD) study. According to age, adolescents were divided into five categorical groups: ≤ 33 weeks, 34–35 36 37–39 ≥ 40 weeks. The NIH Toolbox was used estimate neurocognitive performance, including crystallized fluid intelligence, which measured for baseline intelligence relevant subscales obtained follow-up (with participant numbers ranging 6185 6310 depending on domain). An additional large population-based 618,070 middle ninth-grade (15–16 years) Danish national register utilized validate association between academic achievements. A linear mixed model examine group differences school achievements, grey matter volume. mediation analysis performed whether volumes mediated GA neurocognition, followed a track changes. Results Significant found in all scores, twenty-five cortical regional ( P < 0.05, Bonferroni corrected). Specifically, lower ages graded achievements smaller fronto-parieto-temporal, fusiform, cingulate, insula, postcentral, hippocampal, thalamic, pallidal regions. These function = 1 × 10 −8 , β 0.017, 95% CI: 0.007–0.028). Longitudinal showed that compared full term adolescents, preterm still had scores years. Conclusions results emphasize relationships birth volume, educational many when old. indicates importance screening close behavioral children born are even little than term.

Language: Английский

Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala DOI Creative Commons
Edmund T. Rolls

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 228(5), P. 1201 - 1257

Published: May 13, 2023

The orbitofrontal cortex and amygdala are involved in emotion motivation, but the relationship between these functions performed by brain structures is not clear. To address this, a unified theory of motivation described which motivational states instrumental goal-directed actions to obtain rewards or avoid punishers, emotional that elicited when reward punisher received. This greatly simplifies our understanding for same set genes associated systems can define primary unlearned punishers such as sweet taste pain. Recent evidence on connectivity human indicates value experienced with outputs cortical regions including those language, key region depression changes motivation. has weak effective back humans, implicated brainstem-mediated responses stimuli freezing autonomic activity, rather than declarative emotion. anterior cingulate learning rewards, ventromedial prefrontal providing goals navigation reward-related effects memory consolidation mediated partly via cholinergic system.

Language: Английский

Citations

128
The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome: emotion, memory, and action DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(2), P. 330 - 356

Published: Feb. 4, 2022

The human orbitofrontal cortex, ventromedial prefrontal cortex (vmPFC), and anterior cingulate are involved in reward processing thereby emotion but also implicated episodic memory. To understand these regions better, the effective connectivity between 360 cortical 24 subcortical was measured 172 humans from Human Connectome Project complemented with functional diffusion tractography. has gustatory, olfactory, temporal visual, auditory, pole areas. to pregenual posterior hippocampal system provides for rewards be used memory navigation goals. have supracallosal which projects midcingulate other premotor areas action-outcome learning including limb withdrawal or flight fight aversive nonreward stimuli. lateral outputs language systems inferior frontal gyrus. medial connects nucleus basalis of Meynert septum, damage may contribute impairments by disrupting cholinergic influences on neocortex hippocampus.

Language: Английский

Citations

92
The hippocampus, ventromedial prefrontal cortex, and episodic and semantic memory DOI
Edmund T. Rolls

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 217, P. 102334 - 102334

Published: July 21, 2022

Language: Английский

Citations

92
Hippocampal storage and recall of neocortical “What”–“Where” representations DOI Creative Commons
Edmund T. Rolls, Chenfei Zhang, Jianfeng Feng

et al.

Hippocampus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract A key question for understanding the function of hippocampus in memory is how information recalled from to neocortex. This was investigated a neuronal network model hippocampal system which “What” and “Where” firing rate vectors were applied separate neocortical modules, then activated entorhinal cortex dentate gyrus, CA3, CA1, cortex, backprojections showed that whole could be trained recall neocortex as retrieval cue neocortex, principle up towards theoretical capacity determined largely by number synapses onto any one neuron divided sparseness representation. The synaptic weights imported into an integrate‐and‐fire simulation same architecture, time presenting module approximately 100 ms. sufficiently fast backprojection still active neurons during storage episodic memory, this needed operate correctly These simulations also long loop neocortex–hippocampus–neocortex operates continuously may contribute complete neocortex; but positive feedback makes dynamical inherently liable pathological increase activity. Important factors contributed stability included increased inhibition CA3 CA1 keep rates low; temporal adaptation synapses, are proposed make important contribution stabilizing runaway excitation cortical circuits brain.

Language: Английский

Citations

34
A Theory and Model of Scene Representations With Hippocampal Spatial View Cells DOI Creative Commons
Edmund T. Rolls

Hippocampus, Journal Year: 2025, Volume and Issue: 35(3)

Published: April 28, 2025

ABSTRACT A theory and network model are presented of how scene representations built by forming spatial view cells in the ventromedial visual cortical pathway to hippocampus primates including humans. Layer 1, corresponding V1–V4, connects 2 retrosplenial area uses competitive learning form feature combination neurons for part being fixated, a fixation patch. In 3, parahippocampal hippocampus, patches stitched together whole representations. This is performed with continuous attractor made from overlapping Gaussian receptive fields as head rotates scene. addition, gain modulation gaze direction maps correct representation when saccades made. Each neuron 3 thus cell that responds location viewed based on features The novel conceptual advances this shows may be primates, humans, scenes anchor world (to allocentric, world‐based, space); contributes this. offers revolutionary approach understanding navigation episodic memory

Language: Английский

Citations

2
The human language effective connectome DOI Creative Commons
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

NeuroImage, Journal Year: 2022, Volume and Issue: 258, P. 119352 - 119352

Published: June 2, 2022

To advance understanding of brain networks involved in language, the effective connectivity between 26 cortical regions implicated language by a community analysis and 360 was measured 171 humans from Human Connectome Project, complemented with functional diffusion tractography, all using HCP multimodal parcellation atlas. A (semantic) network (Group 1) involving inferior superior temporal sulcus cortex (STS) adjacent visual TE1a pole TG, connected parietal PGi region, has (TE) regions; PFm which also connectivity; posterior cingulate memory-related frontal pole, orbitofrontal cortex, medial prefrontal cortex; dorsolateral 44 45 for output regions. It is proposed that this system can build its lobe (STS TG) parts (PGi PGs) semantic representations objects incorporating especially their reward properties. Another 3) more including STGa, auditory A5, TPOJ1, STV Peri-Sylvian Language area (PSL) areas (A1, A4, Pbelt); relatively early motion, e.g., MT MST, faces/words (FFC); somatosensory (frontal opercular FOP, insula PF); other TPOJ gyrus (IFJa IFSp). builds specialising related facial motion information useful theory mind / body image information, outputs directed not only to 45, but premotor 55b midcingulate cortex. Both (Groups 1 have access hippocampal episodic memory via parahippocampal TF. third largely 2) (44, 47l; 55b; Superior Frontal region SFL; TGv) receives two systems, syntax speech output.

Language: Английский

Citations

69
The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation DOI
Edmund T. Rolls, Sylvia Wirth, Gustavo Deco

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(2), P. 629 - 655

Published: Sept. 30, 2022

The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory navigation. functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of Posterior Cingulate Division (PCD) regions Human Connectome Project-MMP1 atlas 171 HCP participants, complemented with diffusion tractography. First, postero-ventral parts PCD (31pd, 31pv, 7m, d23ab, v23ab) have temporal pole, inferior visual cortex, superior sulcus implicated auditory semantic processing, reward-related vmPFC pregenual anterior cingulate hippocampal system. This implicates it episodic memory, providing routes for "what," reward schema-related information to access hippocampus. Second, antero-dorsal (especially 31a 23d, PCV, also RSC) early cortical areas including those that represent spatial scenes, "where" component dorsal-transitional-visual (DVT) ProStriate where retrosplenial scene area is located from parahippocampal area, a ventromedial route reach These connectivities provide important reward, scene-related midcingulate provides dorsal supracallosal part premotor regions.

Language: Английский

Citations

64
Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans DOI Creative Commons
Edmund T. Rolls

Hippocampus, Journal Year: 2022, Volume and Issue: 33(5), P. 533 - 572

Published: Sept. 7, 2022

Abstract Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the location being looked at. The representation is allocentric, that responses are locations “out there” world, relatively invariant with respect retinal position, eye head direction, place where individual located. underlying connectivity humans from ventromedial visual cortical regions scene area, leading theory cells formed by combinations of overlapping feature inputs self‐organized based on their closeness space. Thus, although represent “where” for episodic memory navigation, they ventral stream what area. A second driver parietal inputs, which it proposed provide idiothetic update cells, used recall navigation when details obscured. Inferior temporal object “what” orbitofrontal cortex reward connect human hippocampal system, macaques can be associated hippocampus cell representations implement memory. also a basis series viewed landmarks, providing goals then implemented involved visuomotor actions presence foveate vision highly developed lobe processing including key understanding primate hippocampus, roles this system navigation.

Language: Английский

Citations

59
Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology DOI

Hui-Fu Wang,

Wei Zhang, Edmund T. Rolls

et al.

EBioMedicine, Journal Year: 2022, Volume and Issue: 86, P. 104336 - 104336

Published: Nov. 7, 2022

Language: Английский

Citations

58
Multiple cortical visual streams in humans DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(7), P. 3319 - 3349

Published: July 14, 2022

The effective connectivity between 55 visual cortical regions and 360 was measured in 171 HCP participants using the HCP-MMP atlas, complemented with functional diffusion tractography. A Ventrolateral Visual "What" Stream for object face recognition projects hierarchically to inferior temporal cortex, which orbitofrontal cortex reward value emotion, hippocampal memory system. Ventromedial "Where" scene representations connects parahippocampal gyrus hippocampus. An Inferior STS (superior sulcus) Semantic receives from Stream, parietal PGi, ventromedial-prefrontal system language systems. Dorsal via V2 V3A MT+ Complex (including MT MST), connect intraparietal LIP, VIP MIP) involved motion actions space. It performs coordinate transforms idiothetic update of representations. Superior inputs STV, auditory A5, is activated by expression, vocalization, important social behaviour,

Language: Английский

Citations

48