Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 5, 2022
Diabetes
is
a
systemic
disease
in
which
patients
with
diabetes
may
develop
peripheral
neuropathy
of
the
lower
extremities
and
vascular
due
to
long-term
continuous
exposure
high
glucose.
Delayed
wound
healing
one
major
complications
diabetes.
Slow
diabetic
associated
glucose
toxicity.
When
condition
deteriorates,
patient
needs
be
amputated,
seriously
affects
quality
life
even
endangers
patient.
In
general,
delayed
lack
chemokines,
abnormal
inflammatory
response,
angiogenesis
epithelial
formation,
fibroblast
dysfunction.
The
incidence
several
chronic
debilitating
conditions
increasing
diabetes,
such
as
renal
insufficiency,
heart
failure,
hepatic
insufficiency.
Fibrosis
an
inappropriate
deposition
extracellular
matrix
(ECM)
proteins.
It
common
causing
organ
fibrotic
mechanism
fibroblasts
involve
direct
activation
permanent
fibroblasts.
also
degeneration
fibers
after
hyperglycemia
stimulates
immune
cells,
or
organ-specific
parenchymal
cells.
Numerous
studies
confirm
that
play
essential
role
treating
its
complications.
primary
function
construct
reshape
ECM.
Nowadays,
widespread
use
single-cell
RNA
sequencing
(scRNA-seq),
number
have
found
become
critical
sentinel
can
detect
not
only
regulation
response
but
molecular
pattern
related
injury.
By
exploring
heterogeneity
functional
changes
manuscript
discusses
used
immunomodulatory
factors
refractory
healing,
providing
new
ideas
for
treatment
healing.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(30)
Published: Sept. 15, 2023
Wound
healing
is
an
urgent
clinical
challenge,
particularly
in
the
case
of
chronic
wounds.
Traditional
approaches
to
wound
have
limited
therapeutic
efficacy
due
lengthy
times,
risk
immune
rejection,
and
susceptibility
infection.
Recently,
adipose-derived
mesenchymal
stem
cell-derived
exosomes
(ADSC-exos)
emerged
as
a
promising
modality
for
tissue
regeneration
repair.
In
this
study,
development
novel
extracellular
matrix
hydrogel@exosomes
(ECM@exo)
reported,
which
entails
incorporation
ADSC-exos
into
hydrogel
(ECM
hydrogel).
This
solution
forms
at
physiological
temperature
(≈37
°C)
upon
local
injection
site.
ECM@exo
enables
sustained
release
from
ECM
hydrogel,
maintains
high
concentrations
The
displays
good
biocompatibility
biodegradability.
vivo
vitro
results
demonstrate
that
treatment
effectively
reduces
inflammation
promotes
angiogenesis,
collagen
deposition,
cell
proliferation,
migration,
thereby
accelerating
process.
Overall,
innovative
approach
offers
new
avenue
via
biological
with
controlled
exosome
release.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
68, P. 102967 - 102967
Published: Nov. 18, 2023
Oxidative
stress
occurs
through
an
imbalance
between
the
generation
of
reactive
oxygen
species
(ROS)
and
antioxidant
defense
mechanisms
cells.
The
eye
is
particularly
exposed
to
oxidative
because
its
permanent
exposure
light
due
several
structures
having
high
metabolic
activities.
anterior
part
highly
ultraviolet
(UV)
radiation
possesses
a
complex
system
protect
retina
from
UV
radiation.
posterior
exhibits
rates
consumption
leading
subsequently
production
rate
ROS.
Furthermore,
inflammation,
aging,
genetic
factors,
environmental
pollution,
are
all
elements
promoting
ROS
impairing
thereby
representing
risk
factors
stress.
An
abnormal
redox
status
was
shown
be
involved
in
pathophysiology
various
ocular
diseases
segment
eye.
In
this
review,
we
aim
summarize
provide
updated
understanding
on
pathogenesis
common
affecting
surface,
lens,
retina,
optic
nerve.
Moreover,
discuss
potential
therapeutic
approaches
aimed
at
reducing
context.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 17, 2023
Chronic
inflammation
participates
in
the
progression
of
multiple
chronic
diseases,
including
obesity,
diabetes
mellitus
(DM),
and
DM
related
complications.
Diabetic
ulcer,
characterized
by
wounds
that
are
recalcitrant
to
healing,
is
a
serious
complication
tremendously
affecting
quality
life
patients
imposing
costly
medical
burden
on
society.
Matrix
metalloproteases
(MMPs)
family
zinc
endopeptidases
with
capacity
degrading
all
components
extracellular
matrix,
which
play
pivotal
part
healing
process
under
various
conditions
DM.
During
diabetic
wound
dynamic
changes
MMPs
serum,
skin
tissues,
fluid
connection
degree
recovery,
suggesting
can
function
as
essential
biomarkers
for
diagnosis
ulcer.
participate
biological
processes
relevant
such
ECM
secretion,
granulation
tissue
configuration,
angiogenesis,
collagen
growth,
re-epithelization,
inflammatory
response,
well
oxidative
stress,
thus,
seeking
developing
agents
targeting
has
emerged
potential
way
treat
Natural
products
especially
flavonoids,
polysaccharides,
alkaloids,
polypeptides,
estrogens
extracted
from
herbs,
vegetables,
animals
have
been
extensively
illustrated
ulcer
through
MMPs-mediated
signaling
pathways,
discussed
this
review
may
contribute
development
functional
foods
or
drug
candidates
therapy.
This
highlights
regulation
therapeutic
ability
natural
MMPs.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 16, 2022
With
the
global
prevalence
of
diabetes
mellitus
over
recent
decades,
more
patients
suffered
from
various
diabetic
complications,
including
ocular
surface
diseases
that
may
seriously
affect
quality
life
and
even
vision
sight.
The
major
include
keratopathy
dry
eye.
Diabetic
is
characterized
with
delayed
corneal
epithelial
wound
healing,
reduced
nerve
density,
decreased
sensation
feeling
burning
or
dryness.
eye
manifested
as
reduction
tear
secretion
accompanied
discomfort.
early
clinical
symptoms
degeneration,
suggesting
diagnosis
should
be
focused
on
examination
confocal
microscopy
symptoms.
pathogenesis
involves
accumulation
advanced
glycation
end-products,
impaired
neurotrophic
innervations
limbal
stem
cell
function,
dysregulated
growth
factor
signaling,
inflammation
alterations.
associated
abnormal
mitochondrial
metabolism
lacrimal
gland
caused
by
overactivation
sympathetic
nervous
system.
Considering
important
roles
dense
in
homeostatic
maintenance
cornea
gland,
further
studies
neuroepithelial
neuroimmune
interactions
will
reveal
predominant
pathogenic
mechanisms
develop
targeting
intervention
strategies
complications.
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Dec. 20, 2023
The
skeleton
is
a
highly
innervated
organ
in
which
nerve
fibers
interact
with
various
skeletal
cells.
Peripheral
endings
release
neurogenic
factors
and
sense
signals,
mediate
bone
metabolism
pain.
In
recent
years,
tissue
engineering
has
increasingly
focused
on
the
effects
of
nervous
system
regeneration.
Simultaneous
regeneration
nerves
through
use
materials
or
by
enhancement
endogenous
repair
signals
been
proven
to
promote
functional
Additionally,
emerging
information
mechanisms
interoception
central
regulation
homeostasis
provide
an
opportunity
for
advancing
biomaterials.
However,
comprehensive
reviews
this
topic
are
lacking.
Therefore,
review
provides
overview
relationship
between
regeneration,
focusing
applications.
We
discuss
novel
regulatory
explore
innovative
approaches
based
nerve-bone
interactions
Finally,
challenges
future
prospects
field
briefly
discussed.
