Revolutionizing cancer treatment: comprehensive insights into immunotherapeutic strategies

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 9, 2024

Language: Английский

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Revolution in Cancer Treatment Methods: Perspective Review of Factors Affecting the Final Results of Nanoparticles Used in Magnetic Fluid Hyperthermia

Health Sciences Review, Journal Year: 2025, Volume and Issue: unknown, P. 100212 - 100212

Published: Jan. 1, 2025

Language: Английский

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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 24 - 24

Published: Jan. 20, 2025

Background: Cancer remains a leading cause of morbidity and mortality worldwide. Traditional treatments like chemotherapy radiation often result in significant side effects varied patient outcomes. Immunotherapy has emerged as promising alternative, harnessing the immune system to target cancer cells. However, complexity responses tumor heterogeneity challenges its effectiveness. Objective: This mini-narrative review explores role artificial intelligence [AI] enhancing efficacy immunotherapy, predicting responses, discovering novel therapeutic targets. Methods: A comprehensive literature was conducted, focusing on studies published between 2010 2024 that examined application AI immunotherapy. Databases such PubMed, Google Scholar, Web Science were utilized, articles selected based relevance topic. Results: significantly contributed identifying biomarkers predict immunotherapy by analyzing genomic, transcriptomic, proteomic data. It also optimizes combination therapies most effective treatment protocols. AI-driven predictive models help assess response guiding clinical decision-making minimizing effects. Additionally, facilitates discovery targets, neoantigens, enabling development personalized immunotherapies. Conclusions: holds immense potential transforming related data privacy, algorithm transparency, integration must be addressed. Overcoming these hurdles will likely make central component future offering more treatments.

Language: Английский

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Ferroptosis: CD8+T cells’ blade to destroy tumor cells or poison for self-destruction

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 1, 2025

Abstract Ferroptosis represents an emerging, iron-dependent form of cell death driven by lipid peroxidation. In recent years, it has garnered significant attention in the realm cancer immunotherapy, particularly studies involving immune checkpoint inhibitors. This not only enhances our comprehension tumor microenvironment but is also considered a promising therapeutic strategy to address resistance, investigate activation mechanisms, and facilitate development vaccines. The combination immunotherapy with ferroptosis provides innovative targets fresh perspectives for advancing treatment. Nevertheless, cells appear possess wider array evasion strategies compared CD8 + T cells, which have been conclusively shown be more vulnerable ferroptosis. Furthermore, TME can create favorable environment survival invasion. Under this premise, both inducing inhibiting will impact antitumor immunity some extent, even make final result run counter purpose. paper systematically elucidates dual-edged sword role process briefly outlining complexity within TME. It explores potential side effects associated ferroptosis-inducing therapies critically considers combined application ferroptosis-based ICIs. highlights current challenges faced approach points out future directions development.

Language: Английский

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Global trends in clinical trials involving engineered biomaterials

Science Advances, Journal Year: 2024, Volume and Issue: 10(29)

Published: July 17, 2024

Engineered biomaterials are materials specifically designed to interact with biological systems for biomedical applications. This paper offers the comprehensive analysis of global clinical trial trends involving such materials. We surveyed 834 studies in ClinicalTrials.gov database and explored biomaterial types, their initiation points, durations trials. Predominantly, synthetic natural polymers, particularly silicone collagen, used. Trials, focusing on ophthalmology, dentistry, vascular medicine, primarily conducted United States, Canada, Italy. These trials encompass a broad demographic, enrolled fewer than 100 participants. The study duration varied ranging from 0.5 4.5 years. mainly bioresorbable or bioinert, integration cells remaining an underexplored area. Our findings shed light current practices future potentials engineered research, offering insights advancing this dynamic field globally.

Language: Английский

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Immunogenic cell death inducers for cancer therapy: An emerging focus on natural products

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155828 - 155828

Published: June 13, 2024

Language: Английский

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Statin therapy: a potential adjuvant to immunotherapies in hepatocellular carcinoma

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 1, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and accounts for more than 90% primary liver cancer. The advent immune checkpoint inhibitor (ICI)-related therapies combined with angiogenesis inhibition has revolutionized treatment HCC in late-stage unresectable HCC, as ICIs alone were disappointing treating HCC. In addition to altered microenvironment, abnormal lipid metabolism been extensively characterized various types Stains are known their cholesterol-lowering properties long history hypercholesterolemia reducing cardiovascular disease risk. Apart from ICI other conventional therapies, statins frequently used by advanced patients dyslipidemia, which often marked accumulation cholesterol fatty acids liver. Supported a body preclinical clinical studies, may unexpectedly enhance efficacy therapy through regulation inflammatory responses microenvironment. This review discusses changes summarizes evidence benefits stain use prospects possible mechanistic actions transforming microenvironment when immunotherapies. Consequently, statin emerge novel valuable adjuvant immunotherapies

Language: Английский

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Role of Folate Receptor and CD44 in Targeting of Docetaxel and Paclitaxel Fabricated Conjugates for Efficient Cancer Therapy

Journal of Medicine Surgery and Public Health, Journal Year: 2024, Volume and Issue: unknown, P. 100163 - 100163

Published: Dec. 1, 2024

Language: Английский

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Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 8, 2023

Immune checkpoint blockade (ICB) has become a promising strategy in treating advanced cancers, providing significant survival benefits for patients with various cancer types. However, among the vast population of patients, only small fraction are able to respond and derive from ICB therapy. Numerous factors contribute diminished efficacy ICB, complex tumor microenvironment (TME) playing an important role. Therefore, comprehensively understanding intricate composition TME is critical elucidating mechanisms that underlie distinct responses patients. Single-cell RNA sequencing (scRNA-seq) novel technique reveals gene expression profiles individual cells, facilitating investigation heterogeneity at high resolution identification key cell subsets participating response ICB. This review emphasizes importance scRNA-seq studying summarizes recent findings discovery biomarkers predict potential therapeutic targets immunotherapy. These suggest future directions clinical implementation immunotherapy, further advancements precision medicine.

Language: Английский

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Multi-Drug Resistance and Breast Cancer Progression via Toll-Like Receptors (TLRs) Signaling

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3015 - 3030

Published: Aug. 7, 2024

Language: Английский

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